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NGN-PET SIGNED

Modelling Neuron-Glia Networks into a drug discovery platform for Pain Efficacious Treatments - Sofia ref.: 116072

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NGN-PET project word cloud

Explore the words cloud of the NGN-PET project. It provides you a very rough idea of what is the project "NGN-PET" about.

carefully models identification microglia tool ipscs cellular preclinical pain quality injury pathological central solutions pharmaceutical stem neurons life mechanisms chemotherapy nociceptors academic vivo cells forming translate model decipher throughput schwann treat disciplinary co chronification mechanism interplay interactions treatments interdisciplinary human molecular disease patients underlying activates altered pet poorly screening nerve expertise basis compound platforms chronic translation validation situation ngn builds therapeutic neuronal understand rodent pose neuropathic assays circuitry discovery drug components tools cultures neuron interrogated vitro technologies glial knowhow peripheral industrial recapitulate cell hence subsequently frequently np rat team demands therapies predictive hts

Project "NGN-PET" data sheet

The following table provides information about the project.

Coordinator	AXXAM SPA Organization address address: VIA MEUCCI 3 city: BRESSO MILANO postcode: 20091 website: www.axxam.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://ngn-pet.com/
Total cost	3˙050˙000 €
EC max contribution	1˙500˙000 € (49%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-07-two-stage
Funding Scheme	IMI2-RIA
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2020-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AXXAM SPA AXXAM SPA Organization address address: VIA MEUCCI 3 city: BRESSO MILANO postcode: 20091 website: www.axxam.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BRESSO MILANO)	coordinator	450˙000.00
2	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	450˙000.00
3	LIFE AND BRAIN GMBH LIFE AND BRAIN GMBH Organization address address: VENUSBERG-CAMPUS 1 city: BONN postcode: 53127 website: www.lifeandbrain.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	450˙000.00
4	NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN Organization address address: MARKWIESENSTRASSE 55 city: REUTLINGEN postcode: 72770 website: www.nmi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REUTLINGEN)	participant	150˙000.00
5	ESTEVE PHARMACEUTICALS, SA ESTEVE PHARMACEUTICALS, SA Organization address address: PASSEIG DE LA ZONA FRANCA 109, 4A PLANTA city: BARCELONA postcode: 8038 website: www.asteve.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	0.00
6	GRUNENTHAL GMBH GRUNENTHAL GMBH Organization address address: ZIEGLERSTRASSE 6 city: AACHEN postcode: 52078 website: www.grunenthal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	0.00

Map

Project objective

Chronic Neuropathic Pain is frequently associated with peripheral nerve injury or disease. Peripheral injury activates both neuronal and glial components of the peripheral and central cellular circuitry. While it is widely known that the subsequently altered interactions between neurons and glial cells contribute to pain development and to its chronification, the underlying mechanisms are poorly understood. Developing mechanism-based therapies targeting neuron-glial interactions to treat chronic pain will be crucial for improving the quality of life of many patients. Hence the development of novel therapeutic solutions represents a major challenge that demands a multi-disciplinary approach to decipher and understand pathological mechanisms and to translate them into predictive tools for drug development. The NGN-PET consortium addresses this challenge by forming a highly interdisciplinary team that builds upon expertise in areas of academic research on pain mechanisms, industrial knowhow on human stem cell-based tool development, HTS technologies and drug discovery. To achieve its goal we will develop preclinical model systems and assays which recapitulate the human in vivo situation and which can be interrogated for the identification, validation of molecular targets and the development new treatments. A focus of the project will be chemotherapy induced NP and the interplay between nociceptors, microglia and Schwann cells. NGN-PET will carefully characterize rodent in vivo and in vitro models to identify these mechanisms, and will develop rat and human iPSCs based in vitro systems of neuron-glial co-cultures that can be interrogated for targets and used for compound identification and validation. NGN-PET will thus pose the basis for the translation of these model systems into high throughput screening platforms for pharmaceutical research and drug discovery.

Deliverables

List of deliverables.
Interim dissemination and outreach report	Documents, reports	2020-04-08 22:25:47
Data Management Plan	Documents, reports	2020-04-08 22:25:47

Take a look to the deliverables list in detail: detailed list of NGN-PET deliverables.

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