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MALEPREG SIGNED

Male pregnancy – Unravelling the coevolution of parental investment and immune defence

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 MALEPREG project word cloud

Explore the words cloud of the MALEPREG project. It provides you a very rough idea of what is the project "MALEPREG" about.

female    roles    egg    full    functionalization    gene    placentation    microbial    accompanied    biology    tolerance    mammals    de    parental    fresh    traits    broodpouch    immunological    independent    groups    convergent    duplication    composition    vertebrate    transcriptomics    disentangled    investment    young    emergence    mammalian    immune    heavily    genomics    reversed    pregnancy    genomic    arose    adaptive    belongs    model    viviparity    mating    genetic    question    understudied    costliest    benefits    crispr    analysing    regarding    option    utilizing    rearrangements    fitness    sex    gain    vertebrates    external    fertilisation    textbook    male    functions    evolution    unresolved    evolutionary    controversial    severely    seahorses    form    bearing    coevolved    syngnathids    reorganisations    morphological    cas9    caused    neo    genus    drastic    reproduction    pave    elucidate    species    fundamentally    plan    gradient    microbiota    biased    look    novo    co    ideal    trait    pipefishes    basis    engineering   

Project "MALEPREG" data sheet

The following table provides information about the project.

Coordinator		 HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL 

Organization address
address: WISCHHOFSTRASSE 1-3
city: KIEL
postcode: 24148
website: www.geomar.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website https://www.geomar.de/en/staff/fb3/ev/oroth/
 Total cost 1˙499˙989 €
 EC max contribution 1˙499˙989 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL DE (KIEL) coordinator 1˙499˙989.00

Map

 Project objective

The question of how sex roles and parental investment have evolved belongs to the most controversial unresolved issues in evolutionary biology. The costliest form of reproduction regarding parental investment is viviparity. Its independent evolution in most vertebrate groups has required drastic morphological and genomic reorganisations in the sex bearing the young. Yet our knowledge is heavily biased towards mammals, where changes in the immune system and microbial composition are associated with pregnancy and placentation. Which factors have caused the selection and accompanied evolution of viviparity in other vertebrates remains severely understudied. As the evolution of viviparity is a textbook model of convergent evolution, I plan on using a comparative approach to identify selection and fitness benefits leading to the evolution of viviparity. I propose analysing mating system evolution, focusing on the unique evolution of male pregnancy in sex-role reversed syngnathids (pipefishes and seahorses) that show a gradient from external fertilisation to full viviparity and are, thus, ideal to study the evolution of viviparity. Only this genus allows the role of egg production and viviparity to be disentangled, as both traits co-occur in the female in most other species. As immunological tolerance is fundamentally associated with the evolution of pregnancy, I will investigate how male pregnancy has coevolved with adaptive immune system rearrangements and the broodpouch specific microbiota. Comparative genomics, transcriptomics and genetic engineering utilizing CRISPR/Cas9 will elucidate the genetic basis of trait loss and gain required for male pregnancy. In particular, I will assess whether new functions arose via gene duplication and neo-functionalization, via gene co-option or via de novo gene emergence. This proposal will pave the way for studying viviparity evolution beyond the mammalian model and will provide a fresh look at sex roles and parental investment.

 Publications

year authors and title journal last update
List of publications.
2019 Anne Beemelmanns, Maude Poirier, Till Bayer, Sven Kuenzel, Olivia Roth
Microbial embryonal colonization during pipefish male pregnancy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37026-3 		Scientific Reports 9/1 2019-11-07
2019 Charlotte Jessica E. Metcalf, Olivia Roth, Andrea L. Graham
Why leveraging sex differences in immune trade‐offs may illuminate the evolution of senescence
published pages: , ISSN: 0269-8463, DOI: 10.1111/1365-2435.13458 		Functional Ecology 2019-11-07

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The information about "MALEPREG" are provided by the European Opendata Portal: CORDIS opendata.

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