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LIMA SIGNED

Liquid biopsies and Imaging for improved cancer care

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LIMA project word cloud

Explore the words cloud of the LIMA project. It provides you a very rough idea of what is the project "LIMA" about.

correlating dynamic prediction correlation cancer levels detection back microenvironment validate characterization diagnosis measured primary technologies analyze manner precise imaging direct samples expression neoadjuvant breast molecular mrna chemotherapy ctc probe relate undergoing lima clinical therapy isolation either vivo conceptual single treatment tools driving observational lesion liquid tissue model image cell rectal follow introducing computational workflow genomically mutations combination signal monitoring heterogeneity patients biopsies phases combining longitudinal mr biopsy circulating dna ct drug quantitative genetic pillars tumor resistance outcome

Project "LIMA" data sheet

The following table provides information about the project.

Coordinator	PHILIPS ELECTRONICS NEDERLAND BV Organization address address: HIGH TECH CAMPUS 52 city: EINDHOVEN postcode: 5656 AG website: www.philips.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://lima-project.eu/
Total cost	6˙292˙873 €
EC max contribution	6˙292˙873 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2017-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PHILIPS ELECTRONICS NEDERLAND BV PHILIPS ELECTRONICS NEDERLAND BV Organization address address: HIGH TECH CAMPUS 52 city: EINDHOVEN postcode: 5656 AG website: www.philips.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	coordinator	813˙093.00
2	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	1˙606˙347.00
3	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	1˙077˙563.00
4	ALS AUTOMATED LAB SOLUTIONS GMBH ALS AUTOMATED LAB SOLUTIONS GMBH Organization address address: OTTO-EPPENSTEIN-STRASSE 30 city: JENA postcode: 7745 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	participant	547˙145.00
5	AGENA BIOSCIENCE GMBH AGENA BIOSCIENCE GMBH Organization address address: MENDELSSOHNSTR 15 D city: HAMBURG postcode: 22761 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	517˙742.00
6	STILLA TECHNOLOGIES STILLA TECHNOLOGIES Organization address address: 1 MAIL DU PROFESSEUR GEORGES MATHE city: VILLEJUIF postcode: 94800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	483˙532.00
7	ANGLE EUROPE LIMITED ANGLE EUROPE LIMITED Organization address address: GROUND FLOOR 10 NUGENT ROAD SURREY RESEARCH PARK city: GUILDFORD postcode: GU2 7AF website: www.angleplc.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GUILDFORD)	participant	469˙550.00
8	INSTITUT REGIONAL DU CANCER DE MONTPELLIER INSTITUT REGIONAL DU CANCER DE MONTPELLIER Organization address address: RUE DE LA CROIX VERTE 31 PARC EUROMEDECINE city: MONTPELLIER postcode: 34090 website: www.icm.unicancer.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MONTPELLIER)	participant	398˙070.00
9	Philips GmbH Philips GmbH Organization address address: Luebeckertordamm 5 city: Hamburg postcode: 20099 website: www.philips.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Hamburg)	participant	265˙795.00
10	DIADX DIADX Organization address address: 62 CHEMIN DES COMBELLES city: LES MATELLES postcode: 34270 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LES MATELLES)	participant	114˙033.00

Map

Project objective

LIMA’s overall objective is to develop and validate technologies and tools to include liquid biopsies in the clinical workflow, aiming at introducing a more precise and dynamic genetic characterization of tumor at the diagnosis and during treatment phases. This will be done by combining molecular information from liquid biopsies and direct in-vivo tumor characterization from advanced MR imaging, taking into account the current clinical workflow. The LIMA project will be based on following 5 conceptual pillars: 1. A robust method to measure and genomically analyze ct-DNA for tumor-driving mutations, which can be measured in a quantitative manner allowing therapy response prediction and monitoring. 2. A workflow for Circulating Tumor Cell isolation and computational model-based quantitative signal pathway analysis on single CTC mRNA expression levels. This allows for assessment of tumor heterogeneity in pathway activity (to relate back to tumor heterogeneity), targeted therapy response prediction and monitoring 3. Correlation of computational, model-based cancer pathway activity assessment from cancer tissue samples before and after neoadjuvant treatment and from liquid biopsies with MR imaging features. 4. Advance in MR imaging to better probe and image the cancer lesion and its microenvironment 5. Clinical analysis, correlating liquid biopsy/imaging –based results to clinical outcome, that is the response to (targeted drug) neoadjuvant therapy in selected breast cancer and rectal cancer patients. These 5 pillars will be investigated in longitudinal observational studies that will follow patients undergoing neoadjuvant treatment (either chemotherapy or targeted therapy or the combination) for primary rectal and breast cancer. LIMA will demonstrate that prediction of drug therapy response, monitoring of response and detection of resistance can be improved over the current state of the art.

Publications

List of publications.
year	authors and title	journal	last update
2019	A Otandault, P Anker, Z Al Amir Dache, V Guillaumon, R Meddeb, B Pastor, E Pisareva, C Sanchez, R Tanos, G Tousch, H Schwarzenbach, A R Thierry Recent advances in circulating nucleic acids in oncology published pages: 374-384, ISSN: 0923-7534, DOI: 10.1093/annonc/mdz031	Annals of Oncology 30/3	2020-04-07
2019	Romain Meddeb, Ekaterina Pisareva, Alain R. Thierry Guidelines for the Preanalytical Conditions for Analyzing Circulating Cell-Free DNA published pages: 623-633, ISSN: 0009-9147, DOI: 10.1373/clinchem.2018.298323	Clinical Chemistry 65/5	2020-04-07

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The information about "LIMA" are provided by the European Opendata Portal: CORDIS opendata.