Opendata, web and dolomites
Drug the bug
Identification of novel inhibitors to prevent microbial production of pro-diabetic metabolites
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0Drug the bug project word cloud
Explore the words cloud of the Drug the bug project. It provides you a very rough idea of what is the project "Drug the bug" about.
improvements
thereby
humans
inhibitors
mice
bug
capacity
reduce
medication
consolidator
erc
imidazole
microbiota
surgery
explore
envision
diabetes
histidine
metabolism
urda
drug
synthesized
hepatocytes
class
enzyme
sensitivity
primary
successful
linked
gut
diseases
metabolic
resistance
bariatric
microbial
poc
demonstrated
interestingly
injected
award
induce
insulin
altered
propionate
metabolite
Project "Drug the bug" data sheet
The following table provides information about the project.
| Coordinator |
GOETEBORGS UNIVERSITET
Organization address contact info |
| Coordinator Country | Sweden [SE] |
| Total cost | 149˙700 € |
| EC max contribution | 149˙700 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-12-01 to 2019-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | GOETEBORGS UNIVERSITET | SE (GOETEBORG) | coordinator | 149˙700.00 |
Map
Project objective
The gut microbiota has been associated with metabolic diseases, such as type 2 diabetes. In my ERC consolidator award we demonstrated that the gut microbiota is altered following bariatric surgery and that the altered microbiota may be directly linked to some of the metabolic improvements observed following surgery. Interestingly, improved metabolism was associated with altered metabolite production capacity from the microbiota and we observed that a metabolite, imidazole propionate, was reduced after surgery. In associated projects we have demonstrated that imidazole propionate is associated with type 2 diabetes in humans and induce insulin resistance in primary hepatocytes and when injected into mice. Imidazole propionate is synthesized by the microbial enzyme UrdA from histidine. This POC will explore the potential of identifying inhibitors of UrdA to reduce production of imidazole propionate and thereby improve insulin sensitivity. If successful we envision a new class of diabetes medication based on the concept of drug the bug.
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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
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The information about "DRUG THE BUG" are provided by the European Opendata Portal: CORDIS opendata.
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