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NPC-BUILD SIGNED

The Nuclear Pore Basket – Functional Architecture of a Membrane Remodeling Machine

Total Cost €

EC-Contrib. €

Partnership

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NPC-BUILD project word cloud

Explore the words cloud of the NPC-BUILD project. It provides you a very rough idea of what is the project "NPC-BUILD" about.

notably traffic little remodel play inner dna membrane simpler prominent core symmetric form impacts operates bilayer pore structural envelope chromatin complexes environment membranes npcs architecture nucleus single tools central shaping models remodeling lack unlike gatekeepers nucleoplasmic structure expression outer mediating channels flexibility npc lipid size unprecedented critical transformed enigmatic biogenesis nuclear contrast salient function influences transport embedding gene found cytoplasm resolution synergy protein specialized repair basket intricate insert experimental

Project "NPC-BUILD" data sheet

The following table provides information about the project.

Coordinator	MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	2˙178˙488 €
EC max contribution	2˙178˙488 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-02-01 to 2023-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	2˙178˙488.00

Map

Project objective

Nuclear pore complexes (NPCs) are gatekeepers at the nuclear envelope, mediating traffic between the nucleus and cytoplasm. Unlike simpler protein channels that insert into a single lipid bilayer, NPCs can remodel the outer and inner nuclear membranes to form a specialized pore in the nuclear envelope. High-resolution models of the symmetric NPC core have transformed our understanding of NPC architecture. In contrast, we know little about the NPC basket, a prominent structure on the nucleoplasmic side of NPCs. This lack of knowledge is salient, because the basket impacts on transport, DNA repair, and chromatin activity. Notably, the basket was recently found to play a key role in shaping the nuclear membrane, which is critical for NPC biogenesis. Studying the NPC basket is challenging because of its size, intricate architecture, structural flexibility and embedding in a membrane. Yet, knowledge of the architecture of the NPC basket is central to understanding how it influences gene expression, and operates in membrane remodeling in synergy with the NPC core. I propose to develop new experimental tools that will enable a structural analysis of the basket in its membrane environment. This will provide unprecedented insight into the function of this enigmatic part of the NPC.

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The information about "NPC-BUILD" are provided by the European Opendata Portal: CORDIS opendata.