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THIRST SIGNED

Third Strategy in Tissue Engineering – Functional microfabricated multicellular spheroid carriers for tissue engineering and regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 THIRST project word cloud

Explore the words cloud of the THIRST project. It provides you a very rough idea of what is the project "THIRST" about.

types    possibilities    edge    context    technological    inspiring    bottlenecks    organ    avascular    spheroids    enabled    tool    breakthrough    assembly    realization    sight    tissues    representing    fundamental    disease    relies    few    became    applicability    encaged    procedure    vascularized    considerable    demonstrating    despite    holds    urgent    variety    microscaffolds    noble    biofunctionalisation    combination    expectations    radically    protocols    regulatory    focussed    therapies    scientific    multicellular    examples    extremely    repair    engineering    seem    strategy    mostly    translation    desperately    basic    establishing    bone    expanded    cartilage    fairly    community    restricted    conventional    3d    successful    latter    universal    hurdles    nature    represented    strategies    area    substantial    clinical    printed    fact    modules    solution    automated    launch    te    thirst    self    adjustments    pursues    unconventional    microscaffold    interdisciplinary    overcoming    tissue    cutting    box   

Project "THIRST" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET WIEN 

Organization address
address: KARLSPLATZ 13
city: WIEN
postcode: 1040
website: www.tuwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙999˙962 €
 EC max contribution 1˙999˙962 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 1˙746˙837.00
2    LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AT (WIEN) participant 253˙125.00

Map

 Project objective

The field of tissue engineering (TE) pursues a noble goal, driven by the urgent need for tissue and organ repair. It is represented by a fairly large and extremely interdisciplinary scientific community. However, so far TE was not able to deliver to the expectations, with only a few examples of successful clinical translation mostly restricted to a particular disease or tissue type. Despite the fact that all major fundamental bottlenecks of conventional TE strategies have long been identified, a universal solution does not seem to be in sight. In this project I propose to launch a radically new approach, a third strategy in tissue engineering (THIRST), which holds the potential to produce a desperately needed technological breakthrough. THIRST relies on a tissue self-assembly from multicellular spheroids encaged within robust 3D printed microscaffolds. THIRST is enabled by a number of cutting-edge methods, some of which became relevant in the context of TE only recently. In combination, these methods offer a variety of new technological possibilities for the area of TE. The objectives of this project are focussed on establishing the means for automated large-scale production of tissue modules, protocols for microscaffold biofunctionalisation, and demonstrating THIRST potential with highly relevant clinical examples - cartilage, representing avascular tissue, and vascularized bone tissue. A distinct feature of THIRST is its universal applicability, meaning that such a tool-box can be further expanded to encompass other types of tissues without substantial adjustments to the basic tissue assembly procedure. The latter is particularly inspiring, taking into account the considerable regulatory hurdles associated with the development of new TE therapies. Due to its unconventional nature, realization of THIRST relies on overcoming several considerable technological challenges addressed by this project.

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The information about "THIRST" are provided by the European Opendata Portal: CORDIS opendata.

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