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mitozippers SIGNED

Mitochondrial membrane-targeted compounds for cancer therapy

Total Cost €

EC-Contrib. €

Partnership

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mitozippers project word cloud

Explore the words cloud of the mitozippers project. It provides you a very rough idea of what is the project "mitozippers" about.

cancer meets generation whereby waterline cellular 126 viability life regulation survival patients healthcare therapies total toxicity functionally severe mitochondria drug alternative commercializing rate therapeutic cationic death cells quality devoted hallmarks efforts membrane treatments normal eradicate healthy economic proliferation protecting improvement causes lipophilic quantified cell counterparts billion accumulates structurally alternatively malignant exhibit productivity biochemical protein losses

Project "mitozippers" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	149˙700 €
EC max contribution	149˙700 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-07-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD COMPLUTENSE DE MADRID UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	149˙700.00

Map

Project objective

Cancer is one of the leading causes of death in Europe. The economic impact of cancer in Europe has been quantified with a total cost of 126 billion €, including healthcare costs and productivity losses. Although many efforts have been devoted to eradicate cancer, the current treatments are associated with severe side effects and high toxicity. Alternatively, the next generation of cancer treatments targets only malignant cells, which exhibit unique biochemical hallmarks different from their normal counterparts. For example, cancer cell mitochondria are structurally and functionally different from healthy cells. As mitochondria are the waterline of cellular viability, they represent a more effective therapeutic target as compared to current protein targeted therapies. Here, we propose a novel approach whereby the control of cell proliferation and survival is achieved by means of regulation of the membrane properties of the cancer cell mitochondria by means of a lipophilic cationic drug, which efficiently accumulates in mitochondria. Our approach meets the requirements of developing, protecting and commercializing alternative therapies leading to an improvement of life quality and survival rate of cancer patients as well as an improvement in economic terms.

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The information about "MITOZIPPERS" are provided by the European Opendata Portal: CORDIS opendata.