Opendata, web and dolomites

Fields4CAT SIGNED

Force Fields in Redox Enzymatic Catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Fields4CAT project word cloud

Explore the words cloud of the Fields4CAT project. It provides you a very rough idea of what is the project "Fields4CAT" about.

activated    manufacturing    toolbox    time    proteins    functionalization    site    biotechnology    exerted    block    active    platforms    fields4cat    electrostatic    characterizes    mutagenesis    variety    tuned    demanding    map    single    develops    hampered    individual    electrochemical    forces    redox    rational    orientation    trap    quantifies    tunnelling    metal    wild    proposes    govern    junction    fashion    hydrocarbons    precise    biocatalysts    catalysis    protein    driving    usually    sustainable    subject    nanoscale    reactions    enzymatic    pillars    enhanced    s4cat    signatures    catalyze    harsh    connect    mechanical    enzymes    guidelines    electrical    point    ec    near    vertical    electrodes    nature    force    spt    constraining    progressed    static    wise    complexity    catalytic    bio    magnetic    mild    mutation    platform    ing    technological    dissecting    chemical    axis    designs    economy    thanks    obscuring    breakthroughs    stimuli    bioengineer    plugs    interpretation    ray    schemes    oxy    reaction    effect    enzyme    directionality    blocks    industrial    draw    structural    world   

Project "Fields4CAT" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙998˙700 €
 EC max contribution 1˙998˙700 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 1˙998˙700.00
2    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 0.00

Map

 Project objective

Fields4CAT aims to identify the nature and directionality of the driving forces in a redox enzyme that govern the catalytic chemical process. Industrial bio-manufacturing is one of the pillars of today’s world economy making its way to a sustainable development. Redox enzymes catalyze the most demanding chemical reactions under mild conditions, such as the oxy-functionalization of non-activated hydrocarbons, which usually requires harsh reaction conditions. Enzyme Biotechnology has greatly progressed thanks to rational mutagenesis schemes that draw upon the static X-ray structural information. The high complexity of enzymatic catalysis has, however, hampered its development because a single point mutation near the active site can affect several relevant parameters at the same time, obscuring the interpretation and constraining the rational design of technological biocatalysts. Fields4CAT proposes dissecting the relevant forces exerted over an individual catalytic active site in its wild-type state, and then using the resulting forces map to design enzyme/metal platforms with enhanced capabilities. To this aim, it develops in 3 blocks organized in a step-wise fashion: (i) block 1 sets up a electrochemical multi-stimuli single-protein toolbox (Ec-SPT) with capabilities to trap individual proteins in a nanoscale tunnelling junction and subject them to a variety of force stimuli, i.e. mechanical, electrostatic and magnetic. (ii) Block 2 designs the chemical electrical plugs that will specifically connect the enzyme to the junction electrodes with precise controlled orientation. (iii) Block 3 characterizes the single-protein electrical signatures of the enzyme activity and quantifies the catalytic effect of the different force stimuli along the vertical junction axis. Fields4CAT will identify new guidelines to bioengineer a redox enzyme/metal platform with tuned catalytic activity, bringing about new breakthroughs in the future of Bio-Catalysis.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FIELDS4CAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FIELDS4CAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More