Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. mimetico

MIMetiCO SIGNED

Multiscale Integrative Approach for Corneal Biomechanics to Assess Corneal Crosslinking

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MIMetiCO project word cloud

Explore the words cloud of the MIMetiCO project. It provides you a very rough idea of what is the project "MIMetiCO" about.

mimetico    social    experiments    biomechanics    usually    mainly    internal    computational    microscopy    crosslinks    treatment    pathologies    scales    interventions    inducing    intraocular    depending    stiffening    multiscale    surgery    unexpected    structural    biochemical    pressure    crosslinking    macroscopic    framework    stiffness    250    becomes    nano    phenomena    mechanical    virtual    chemical    protrusion    keratoconus    collagen    breaking    inflation    people    postsurgical    orientation    million    modeling    ectasias    outcomes    tissue    intermolecular    worldwide    confocal    treatments    model    bounding    technologies    models    strategies    micro    generation    cornea    vision    silico    characterization    rely    economic    amount    mechanisms    refractive    stresses    density    completely    balance    ophthalmology    halting    fibrils    impaired    molecules    benefit    simulate    imbalanced    visually    approximately    clinical    ground    cxl    uniformly    combine    tests    first    calibrate    noninvasive    plan    corneal    morphological   

Project "MIMetiCO" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 175˙419.00

Map

 Project objective

Approximately 250 million people worldwide are visually impaired, and this has great economic and social impact. One of the pathologies of vision loss is keratoconus, in which the mechanical balance of the cornea depending on intraocular pressure and internal stresses in corneal tissue becomes imbalanced, which can result in a corneal protrusion.

Corneal crosslinking (CXL) is a clinical treatment that increases the overall mechanical stiffness of the cornea by inducing chemical bounding between collagen molecules. CXL is the present of halting corneal ectasias, and the future of noninvasive refractive surgery. However, its micro/nano-mechanisms are not completely understood. Moreover, CXL is usually applied uniformly in corneal treatments, which can result in over-stiffening and unexpected postsurgical outcomes.

Ophthalmology can benefit from in silico modeling to plan and improve such interventions. However, current computational models are mainly macroscopic and cannot simulate complex phenomena involved in CXL. Multiscale computational models could improve clinical strategies by including information at different scales.

MIMetiCO’s goal is to combine experiments and modelling at different scales to provide a multiscale characterization of corneal biomechanics before and after CXL. This characterization will rely on both ground-breaking and well-established technologies that include confocal microscopy, biochemical assessment, and mechanical inflation tests to determine morphological (orientation and density of fibrils), biochemical (amount of intermolecular crosslinks), and mechanical features of the cornea.

MIMetiCO will use this information to calibrate the first in silico model of the cornea using a multiscale structural approach to build a virtual framework to simulate potential CXL treatments.

MIMetiCO is the next step in ophthalmology, which has the potential to bring into being a new generation of clinical assessment.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MIMETICO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MIMETICO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

DIFFER (2020)

Determinants of genetic diversity: Important Factors For Ecosystem Resilience

Read More  

SingleCellAI (2019)

Deep-learning models of CRISPR-engineered cells define a rulebook of cellular transdifferentiation

Read More  

PocketLight (2020)

Compact all-fibre nonlinear resonators as technological platform for a new generation of miniaturised light sources.

Read More