Opendata, web and dolomites
CircaCHIP SIGNED
Development of Circadian Rhythms on Chip
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0CircaCHIP project word cloud
Explore the words cloud of the CircaCHIP project. It provides you a very rough idea of what is the project "CircaCHIP" about.
acetaminophen
mimic
et
idiopathic
2016
tissue
rhythms
synchronization
drug
vitro
rational
nutritional
inverted
efficient
day
model
levy
libraries
troglitazone
pharmaceuticals
quantum
2015
tracks
efforts
metabolic
platform
chip
liver
dependent
metabolism
leap
drugs
fatty
create
responsible
highlighted
explained
diseases
little
assembled
systemic
formulate
temperature
time
toxicity
lack
physiology
dynamically
models
expandable
differences
hepatocytes
inability
properly
night
disease
changing
captures
pressing
circadian
stems
idiosyncratic
dynamics
describe
diabetes
function
predict
physiological
al
biotechnology
prevalent
interventions
responding
hormones
animal
microfluidic
self
pnas
livers
edge
oscillations
pharmaceutical
limited
capability
pharmacokinetics
bavli
groundbreaking
clearance
nature
cutting
predicting
complexity
chronopharmacology
compounded
micro
obesity
environment
regulation
human
hormonal
generation
cycles
Project "CircaCHIP" data sheet
The following table provides information about the project.
| Coordinator |
THE HEBREW UNIVERSITY OF JERUSALEM
Organization address contact info |
| Coordinator Country | Israel [IL] |
| Total cost | 149˙969 € |
| EC max contribution | 149˙969 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-06-01 to 2019-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE HEBREW UNIVERSITY OF JERUSALEM | IL (JERUSALEM) | coordinator | 149˙969.00 |
Map
Project objective
The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. Chronopharmacology). The problem stems from our inability to model the dynamics of human metabolism in vitro, and compounded by the failure of animal models to predict human response due to differences in physiology, metabolic regulation, and an inverted day/night cycles. In addition, in vitro hepatocytes show little to no metabolic function and lack the physiological complexity of human tissue. Therefore, there is a pressing need to develop models that mimic human physiological complexity. Recently, we established groundbreaking libraries of expandable human hepatocytes (Levy et al. Nature Biotechnology 2015) and a cutting-edge liver-on-chip platform that tracks metabolic dynamics in real time (Bavli et al. PNAS 2016). Our technology explained the idiopathic toxicity of acetaminophen and the idiosyncratic toxicity of troglitazone and was recently highlighted by the H2020 program. Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. Our next generation model for liver metabolism will present a quantum leap in capability, offering to go beyond animal models by predicting time-of-day dependent toxicity and drug clearance. In addition, we will enable the rational design of a new generation of pharmaceuticals
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