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iPC SIGNED

individualizedPaediatricCure: Cloud-based virtual-patient models for precision paediatric oncology

Total Cost €

EC-Contrib. €

Partnership

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iPC project word cloud

Explore the words cloud of the iPC project. It provides you a very rough idea of what is the project "iPC" about.

harmonize summary optimal incidence single query leaders combinations experimental workflows medicine tumour prospectively critical effort excellence science disciplinary standard translational child market silico inform quality molecular avatars standardize computational preclinical therapies models types leverage accessible diagnostics tumours panel givers children risk consisting citizens infrastructure goals combine centres care virtual select assembled respective treatments multitude effective trials construct treatment team amongst cancers digitalization clinical hpc drawbacks basic personalized digital overcome benefits learning big settings predictions base ipc data patient relationships predict maximised domain interdisciplinary cancer platform paediatric cloud machine recommend mechanistic assays assemble infer

Project "iPC" data sheet

The following table provides information about the project.

Coordinator	TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH Organization address address: BURGPLATZ 3A city: VILLACH postcode: 9500 website: https://urldefense.com/v3/__https://technikon.com__;!!DOxrgLBm!XQj8lX3wvrhxnrAflv0OBz99-qlU79olpwsKnLk7T4NxnEuLngVJcmEmxcnyX1OKvqUsEW_8DocHehV2MbBX$ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	15˙066˙525 €
EC max contribution	14˙748˙400 € (98%)
Programme	1. H2020-EU.3.1.5.3. (Using in-silico medicine for improving disease management and prediction)
Code Call	H2020-SC1-DTH-2018-1
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH Organization address address: BURGPLATZ 3A city: VILLACH postcode: 9500 website: https://urldefense.com/v3/__https://technikon.com__;!!DOxrgLBm!XQj8lX3wvrhxnrAflv0OBz99-qlU79olpwsKnLk7T4NxnEuLngVJcmEmxcnyX1OKvqUsEW_8DocHehV2MbBX$ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (VILLACH)	coordinator	513˙004.00
2	IBM RESEARCH GMBH IBM RESEARCH GMBH Organization address address: SAEUMERSTRASSE 4 city: RUESCHLIKON postcode: 8803 website: www.zurich.ibm.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (RUESCHLIKON)	participant	2˙020˙506.00
3	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	1˙451˙213.00
4	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	1˙381˙550.00
5	BAYLOR COLLEGE OF MEDICINE BAYLOR COLLEGE OF MEDICINE Organization address address: ONE BAYLOR PLAZA T119 city: HOUSTON TX postcode: 77030 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (HOUSTON TX)	participant	1˙104˙991.00
6	BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION Organization address address: Calle Jordi Girona 31 city: BARCELONA postcode: 8034 website: www.bsc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	980˙414.00
7	ALACRIS THERANOSTICS GMBH ALACRIS THERANOSTICS GMBH Organization address address: MAX PLANCK STRASSE 3 city: BERLIN postcode: 12489 website: www.alacris.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	861˙444.00
8	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	769˙881.00
9	TECHNISCHE UNIVERSITAT DARMSTADT TECHNISCHE UNIVERSITAT DARMSTADT Organization address address: KAROLINENPLATZ 5 city: DARMSTADT postcode: 64289 website: www.tu-darmstadt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DARMSTADT)	participant	720˙673.00
10	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	668˙974.00
11	PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV Organization address address: HEIDELBERGLAAN 25 city: UTRECHT postcode: 3584CS website: www.prinsesmaximacentrum.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	629˙109.00
12	DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 280 city: HEIDELBERG postcode: 69120 website: www.dkfz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	531˙691.00
13	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Organization address address: CORSO UMBERTO I, 40 city: NAPOLI postcode: 80138 website: www.unina.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NAPOLI)	participant	482˙857.00
14	UNIVERSITATSKLINIKUM HEIDELBERG UNIVERSITATSKLINIKUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 website: www.klinikum.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	452˙750.00
15	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	437˙262.00
16	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	414˙838.00
17	INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL Organization address address: CTRA DE CANYET S/N city: BADALONA BARCELONA postcode: 8916 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BADALONA BARCELONA)	participant	397˙398.00
18	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	384˙940.00
19	XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO Organization address address: POT ZA BRDOM 100 city: LJUBLJANA postcode: 1000 website: http://xlab.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	369˙243.00
20	THE CHILDREN'S HOSPITAL OF PHILADELPHIA NON PROFIT ORG THE CHILDREN'S HOSPITAL OF PHILADELPHIA NON PROFIT ORG Organization address address: Civic Center Blvd city: Philadelphia postcode: 19104 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Philadelphia)	participant	175˙652.00
21	CHILDREN'S MEDICAL RESEARCH INSTITUTE CHILDREN'S MEDICAL RESEARCH INSTITUTE Organization address address: 214 HAWKESBURY ROAD city: WESTMEAD, NEW SOUTH WALES postcode: 2145 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (WESTMEAD, NEW SOUTH WALES)	participant	0.00

Map

Project objective

Effective personalized medicine for paediatric cancers must address a multitude of challenges, including domain-specific challenges. To overcome these challenges, we propose a comprehensive computational effort to combine knowledge-base, machine-learning, and mechanistic models to predict optimal standard and experimental therapies for each child. Our approach is based on virtual patient models–in-silico avatars whose analysis can inform personalized diagnostics and recommend treatments. Our platform will also allow care givers to query models and infer benefits and drawbacks for specific treatment combinations for each child. To construct these models, we will combine state-of-the-art computational methods and data from molecular assays, and clinical and preclinical studies. We will test their predictions prospectively on data from clinical trials and test therapies in pre-clinical settings. We will focus on a select panel of paediatric tumours including both high-incidence and high-risk tumour types. To accomplish our goals, we have assembled an interdisciplinary team consisting of basic, translational, and clinical researchers—all amongst the leaders in their respective fields—and established strong relationships with European Centres of Excellence, patient organizations, and clinical trials focus on personalized medicine for our proposed case studies. We will produce, assemble, standardize, and harmonize accessible high-quality multi-disciplinary data and leverage the potential of Big Data and HPC for the personalized treatments of European citizens. We will make our models and data available through a cloud-based platform, whose exploitation will be maximised through a collaboration with the European Open Science Cloud initiative. In summary, iPC will address the critical need for personalized medicine for children with cancer, contribute to the digitalization of clinical workflows, and enable the Digital Single Market of the EU data infrastructure.

Publications

List of publications.
year	authors and title	journal	last update
2019	Dominik Linzner Michael Schmidt Heinz Koeppl Scalable Structure Learning of Continuous-Time Bayesian Networks from Incomplete Data published pages: , ISSN: , DOI:	33rd Conference on Neural Information Processing Systems (NeurIPS 2019)	2020-03-23
2019	Dominik Linzner Heinz Koeppl A Variational Perturbative Approach to Planning in Graph-based Markov Decision Processes published pages: , ISSN: , DOI:	Association for the Advancement of Artificial Intelligence	2020-03-23

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