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MechanoGenetic SIGNED

Role of mechanical forces in cell-matrix adhesion sites

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoGenetic project word cloud

Explore the words cloud of the MechanoGenetic project. It provides you a very rough idea of what is the project "MechanoGenetic" about.

threshold    mechanosensing    myotendinous    mechanotransmission    complementary    muscle    forces    bodies    microenvironment    fly    mechanosensor    integrate    talin    contractility    cells    mutants    fret    striking    organisation    ipp    alters    integrity    core    ecm    first    tight    combat    interdisciplinary    biophysical    adhesome    either    deeper    vivo    framework    hold    embryo    adhesions    lose    sense    dystrophies    module    transmitted    critical    integrin    genetic    elevated    magnetic    tweezers    adhesive    muscular    biosensors    healthily    discover    living    networks    relationship    suitable    tissue    certain    organism    tension    cell    mechanical    junctions    similarities    combining    group    utilizing    collectively    molecular    extracellular    examine    binding    tissues    laser    drosophila    function    modulate    strength    ablation    adhesion    dissociated    constantly    quantify    human    matrix    diseases    dystrophic    outcome   

Project "MechanoGenetic" data sheet

The following table provides information about the project.

Coordinator
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON 

Organization address
address: SORANOU EFESIOU 4
city: ATHINA
postcode: 115 27
website: www.bioacademy.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 153˙085 €
 EC max contribution 153˙085 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) coordinator 153˙085.00

Map

 Project objective

Cells in our bodies constantly experience mechanical forces from their microenvironment. When cells sense a critical threshold of elevated tension, they hold tight together and allow tissues to function healthily as a group. In certain diseases, however, our cells lose their mechanosensing and adhesive properties and, as a result they get dissociated, as in the case of muscular dystrophies. Integrin-based adhesions to the extracellular matrix (ECM) are emerging as key networks of mechanotransmission. This proposal aims to discover how mechanical forces modulate cell-matrix adhesion at the myotendinous junctions in the developing Drosophila embryo, combining biophysical, molecular and genetic approaches. To achieve this goal, I propose to implement two complementary specific objectives: First, I will identify and quantify the relationship between forces and adhesion strength in mutants affecting either integrin-ECM binding or muscle contractility by utilizing in vivo laser ablation and magnetic tweezers. Second, I will examine whether and how IPP complex -a core module of the integrin adhesome- alters the molecular forces transmitted across Talin, which is a major mechanosensor at integrin junctions, utilizing suitable FRET-based biosensors. Collectively, this interdisciplinary research will provide a novel mechanical framework of how cells integrate forces and maintain tissue integrity in the living organism. Given the striking similarities in the molecular organisation of the myotendinous junctions between fly and human, the outcome of this work will provide a deeper understanding of how we can better combat dystrophic diseases.

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The information about "MECHANOGENETIC" are provided by the European Opendata Portal: CORDIS opendata.

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