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MechanoGenetic SIGNED

Role of mechanical forces in cell-matrix adhesion sites

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MechanoGenetic project word cloud

Explore the words cloud of the MechanoGenetic project. It provides you a very rough idea of what is the project "MechanoGenetic" about.

transmitted    biosensors    collectively    dissociated    human    module    tissues    mutants    tweezers    complementary    muscle    quantify    molecular    cell    contractility    tension    fret    combat    genetic    forces    matrix    binding    adhesive    cells    living    dystrophies    tissue    similarities    laser    integrin    extracellular    sense    critical    combining    mechanosensing    function    suitable    integrity    utilizing    strength    magnetic    lose    examine    bodies    ecm    framework    first    ipp    vivo    adhesions    healthily    mechanical    organisation    biophysical    threshold    elevated    drosophila    tight    group    constantly    modulate    discover    muscular    microenvironment    interdisciplinary    deeper    fly    mechanosensor    dystrophic    junctions    core    either    organism    adhesome    adhesion    networks    talin    integrate    striking    certain    alters    myotendinous    diseases    ablation    embryo    mechanotransmission    hold    relationship    outcome   

Project "MechanoGenetic" data sheet

The following table provides information about the project.

Coordinator
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON 

Organization address
address: SORANOU EFESIOU 4
city: ATHINA
postcode: 115 27
website: www.bioacademy.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 153˙085 €
 EC max contribution 153˙085 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) coordinator 153˙085.00

Map

 Project objective

Cells in our bodies constantly experience mechanical forces from their microenvironment. When cells sense a critical threshold of elevated tension, they hold tight together and allow tissues to function healthily as a group. In certain diseases, however, our cells lose their mechanosensing and adhesive properties and, as a result they get dissociated, as in the case of muscular dystrophies. Integrin-based adhesions to the extracellular matrix (ECM) are emerging as key networks of mechanotransmission. This proposal aims to discover how mechanical forces modulate cell-matrix adhesion at the myotendinous junctions in the developing Drosophila embryo, combining biophysical, molecular and genetic approaches. To achieve this goal, I propose to implement two complementary specific objectives: First, I will identify and quantify the relationship between forces and adhesion strength in mutants affecting either integrin-ECM binding or muscle contractility by utilizing in vivo laser ablation and magnetic tweezers. Second, I will examine whether and how IPP complex -a core module of the integrin adhesome- alters the molecular forces transmitted across Talin, which is a major mechanosensor at integrin junctions, utilizing suitable FRET-based biosensors. Collectively, this interdisciplinary research will provide a novel mechanical framework of how cells integrate forces and maintain tissue integrity in the living organism. Given the striking similarities in the molecular organisation of the myotendinous junctions between fly and human, the outcome of this work will provide a deeper understanding of how we can better combat dystrophic diseases.

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The information about "MECHANOGENETIC" are provided by the European Opendata Portal: CORDIS opendata.

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