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Hepatic Thermogenesi SIGNED

Study the functions of the hepatic sympathetic nerve and the receptor Adrb3 in liver-mediated adaptive thermogenesis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Hepatic Thermogenesi project word cloud

Explore the words cloud of the Hepatic Thermogenesi project. It provides you a very rough idea of what is the project "Hepatic Thermogenesi" about.

characterization    purpose    observations    nerve    constants    prolonged    foundation    techniques    guarded    treatment    breakthrough    adaptive    heating    evolution    genetic    metabolic    clinical    heat    first    interdisciplinary    metabolomics    edge    sympathectomy    mechanisms    normally    exchange    technologies    core    generation    generate    demonstrating    mice    surgical    exposed    homeothermic    species    disease    proteomic    temperature    adrb3    data    omics    regulation    demonstrated    physiological    triggered    chemistry    regulated    tissues    physics    whereby    homoeothermic    cold    extra    longstanding    thermogenesis    ablation    existence    avenues    preliminary    nonalcoholic    thermogenic    physiology    environment    ascertain    fatty    combination    knockout    liver    regulating    receptor    sympathetic    molecular    fundamental    transcriptomic    adrenergic    anatomical    cutting    rewiring    mechanism    beta    body    hepatic    hepatocytes    argue    sustain   

Project "Hepatic Thermogenesi" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 203˙149.00

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 Project objective

Core body temperature is among the best-guarded constants in homeothermic species. It results from the evolution of physiological mechanisms capable of regulating the production as well as the exchange of heat with the environment. The objective of my proposal is to define a new role for the liver in adaptive thermogenesis whereby the liver will be involved in heat production under the regulation of the hepatic sympathetic nerve. I will first ascertain that the liver can generate extra heat when adaptive thermogenesis is triggered (Aim 1). Hepatic adaptive thermogenesis will be demonstrated using a combination of interdisciplinary, cutting-edge technologies normally applied to the fields of physics and chemistry. I will then determine the molecular foundation of this hepatic heat production (Aim 2). For this purpose, OMICs data (transcriptomic, proteomic and metabolomics) will be generated from cold-exposed liver tissues in order to identify: (1) the hepatic molecular heating mechanism; (2) the expected metabolic rewiring necessary to sustain prolonged heat production from thermogenic hepatocytes. Finally, I will study how hepatic adaptive thermogenesis is regulated by the hepatic sympathetic nerve at the anatomical level and by the adrenergic receptor Adrb3 at the molecular level (Aim 3). For this purpose, I will use a combination of surgical (hepatic sympathectomy) and genetic (generation of liver-specific beta-adrenergic receptor 3 knockout mice) ablation techniques. Longstanding observations, together with my own preliminary results argue for this existence of hepatic adaptive thermogenesis and its molecular characterization would certainly represent a major breakthrough for both our fundamental understanding of homoeothermic physiology as well as for future clinical applications. Demonstrating that the liver is involved in adaptive thermogenesis would certainly open new avenues for the treatment of nonalcoholic fatty liver disease, a major disease in Europe.

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