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ProTeCT SIGNED

Proteasome as a target to combat trichomoniasis

Total Cost €

EC-Contrib. €

Partnership

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ProTeCT project word cloud

Explore the words cloud of the ProTeCT project. It provides you a very rough idea of what is the project "ProTeCT" about.

critical compounds drugs subunit enzyme parasite infection emergence options tv trichomonas sexually fluorescent public urgent monitor ing trichomoniasis underexploited closely accelerating spp crystallization substrates anti parasitic alternative data proteasome antibiotics resistance world antibiotic hit structurally libraries protozoan biochemical approved screened co survival transmitted pose determined threat health ultimately caused substrate designed rationally functionally viral structural inhibitors specificity treatment

Project "ProTeCT" data sheet

The following table provides information about the project.

Coordinator	USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. Organization address address: FLEMINGOVO NAM. 542/2 city: PRAHA 6 postcode: 16610 website: www.uochb.cas.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Czech Republic [CZ]
Total cost	237˙756 €
EC max contribution	237˙756 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-GF
Starting year	2019
Duration (year-month-day)	from 2019-11-01 to 2022-11-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. Organization address address: FLEMINGOVO NAM. 542/2 city: PRAHA 6 postcode: 16610 website: www.uochb.cas.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 6)	coordinator	237˙756.00
2	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Organization address address: FRANKLIN STREET 1111, 12 FLOOR city: OAKLAND CA postcode: 94607 website: http://www.universityofcalifornia.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (OAKLAND CA)	partner	0.00

Map

Project objective

Trichomoniasis, caused by the protozoan parasite Trichomonas spp., is the most common, non-viral, sexually transmitted infection in the world. Only two closely related antibiotic drugs are approved for its treatment. The accelerating emergence of resistance to current antibiotics and no alternative treatment options pose an increasing threat to public health, resulting in an urgent need for novel effective anti-parasitic compounds. This project focuses on Trichomonas proteasome that is an underexploited enzyme critical for parasite survival. In this proposal, the proteasome will be functionally and structurally characterized. The substrate specificity of each subunit will be determined and fluorescent substrates that can monitor activity of each subunit will be designed. Libraries of proteasome inhibitors will be screened and hit compounds will be analyzed in co-crystallization studies with Tv proteasome. Ultimately, biochemical and structural data will be used to rationally design inhibitors for treatment of trichomoniasis.

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The information about "PROTECT" are provided by the European Opendata Portal: CORDIS opendata.