Opendata, web and dolomites
TOPOCELL SIGNED
A cell separation microfabricated platform for cell migration and invasion assays
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0TOPOCELL project word cloud
Explore the words cloud of the TOPOCELL project. It provides you a very rough idea of what is the project "TOPOCELL" about.
substrates
anticipate
homeostasis
technologies
cell
physical
composition
transcell
erc
ultimately
genetic
stiffness
encounter
resolutions
functions
tissue
transmigrate
probe
therapies
environment
possibilities
investigations
tumor
therapy
inflammation
confinement
cellular
microfluidic
matrix
micropillar
biological
differentiation
expression
accurate
pillars
ordered
spreading
migration
limitations
offers
spatial
sorting
porosity
temporal
microfabricated
versatile
prevent
analyze
micron
limited
geometry
environments
topography
plane
microenvironment
confined
biology
profiles
progression
nanotechnology
interactions
answer
physiological
tools
accepted
overcome
contain
micro
versatility
screening
easily
designed
transmigration
tissues
surrounding
sized
assays
substrate
tuned
favor
fundamental
narrow
near
boyden
elastomeric
chambers
variability
incorporating
duracell
cells
spaces
wounds
drug
Project "TOPOCELL" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2021-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 150˙000.00 |
Map
Project objective
Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.
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The information about "TOPOCELL" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-05-14 6:13:24) correctly updated