Opendata, web and dolomites


Metabolic flexibility: breaking down food effectively to prolong life

Total Cost €


EC-Contrib. €






Project "MetaFlex" data sheet

The following table provides information about the project.


Organization address
address: MEIBERGDREEF 15
postcode: 1105AZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙446 €
 EC max contribution 1˙499˙446 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Aging has long been considered a passive process. More recently studies have defined an important, active role for metabolic pathways in aging and age-related diseases. I have previously demonstrated a marked dysregulation of fat metabolism in aged mice that contributes to their overweight and glucose intolerance. Here, I propose a model that links healthy aging to efficient processing of nutrients, a state termed metabolic flexibility: reducing protein or carbohydrate metabolism will strongly stimulate fat breakdown. I suggest that improved metabolic flexibility will thus prevent the accumulation of lipids and protect against its detrimental effects.

In this project, I aim to elucidate how nutrient breakdown is regulated and can be adapted to improve metabolic flexibility and promote healthy aging. I will use C. elegans, as well as mammalian models and human population studies. Specifically, I aim to (1) dissect the molecular actors of metabolic aging pathways; (2) identify genes that translate nutritional cues to lifespan variation; (3) find novel genetic regulators that prevent toxicity and accelerated aging caused by fat-rich diets; (4) identify associations between variants in genes involved in metabolic flexibility and aging phenotypes in humans.

This set of experiments should clarify the role of nutrient breakdown and metabolic flexibility in aging. Better understanding of these processes can lead to a prolonged healthy state of aged individuals.


year authors and title journal last update
List of publications.
2018 Ntsiki M. Held, Eline N. Kuipers, Michel van Weeghel, Jan Bert van Klinken, Simone W. Denis, Marc Lombès, Ronald J. Wanders, Frédéric M. Vaz, Patrick C. N. Rensen, Arthur J. Verhoeven, Mariëtte R. Boon, Riekelt H. Houtkooper
Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27875-3
Scientific Reports 8/1 2019-11-22
2018 Marte Molenaars, Georges E Janssens, Toon Santermans, Marco Lezzerini, Rob Jelier, Alyson W MacInnes, Riekelt H Houtkooper
Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation
published pages: e201800082, ISSN: 2575-1077, DOI: 10.26508/lsa.201800082
Life Science Alliance 1/5 2019-11-22
2019 Yasmine J. Liu, Georges E. Janssens, Rebecca L. McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W. Gao, Aldo Jongejan, Michel van Weeghel, Alyson W. MacInnes, Riekelt H. Houtkooper
Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion
published pages: e1007633, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007633
PLOS Genetics 15/3 2019-11-22
2019 Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens
From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs
published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201809854
EMBO Molecular Medicine 11/9 2019-11-22
2018 Arwen W. Gao, Mark G. Sterken, Jelmi uit de Bos, Jelle van Creij, Rashmi Kamble, Basten L. Snoek, Jan E. Kammenga, Riekelt H. Houtkooper
Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels
published pages: 1296-1308, ISSN: 1088-9051, DOI: 10.1101/gr.232322.117
Genome Research 28/9 2019-11-22
2016 Jeannette C. Bleeker, Riekelt H. Houtkooper
Sirtuin activation as a therapeutic approach against inborn errors of metabolism
published pages: 565-572, ISSN: 0141-8955, DOI: 10.1007/s10545-016-9939-8
Journal of Inherited Metabolic Disease 39/4 2019-09-02
2015 I. A. Chatzispyrou, N. M. Held, L. Mouchiroud, J. Auwerx, R. H. Houtkooper
Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research
published pages: 4446-4449, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-15-1626
Cancer Research 75/21 2019-09-02
2015 Ntsiki M. Held, Riekelt H. Houtkooper
Mitochondrial quality control pathways as determinants of metabolic health
published pages: 867-876, ISSN: 0265-9247, DOI: 10.1002/bies.201500013
BioEssays 37/8 2019-09-02
2016 Mandy Koopman, Helen Michels, Beverley M Dancy, Rashmi Kamble, Laurent Mouchiroud, Johan Auwerx, Ellen A A Nollen, Riekelt H Houtkooper
A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans
published pages: 1798-1816, ISSN: 1754-2189, DOI: 10.1038/nprot.2016.106
Nature Protocols 11/10 2019-09-02
2017 Arwen W. Gao, Jelmi uit de Bos, Mark G. Sterken, Jan E. Kammenga, Reuben L. Smith, Riekelt H. Houtkooper
Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans
published pages: , ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2017.09.006
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2019-09-02
2017 Arwen W. Gao, Iliana A. Chatzispyrou, Rashmi Kamble, Yasmine J. Liu, Katharina Herzog, Reuben L. Smith, Henk van Lenthe, Martin A. T. Vervaart, Arno van Cruchten, Angela C. Luyf, Antoine van Kampen, Mia L. Pras-Raves, Frédéric M. Vaz, Riekelt H. Houtkooper
A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-02539-w
Scientific Reports 7/1 2019-09-02
2015 Xu Wang, Dongryeol Ryu, Riekelt H. Houtkooper, Johan Auwerx
Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment
published pages: 1045-1053, ISSN: 0265-9247, DOI: 10.1002/bies.201500071
BioEssays 37/10 2019-09-02

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "METAFLEX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "METAFLEX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  


Economic Fluctuations, Productivity Growth and Stabilization Policies: A Keynesian Growth Perspective

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More