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BLOODCELLSCROSSTALK SIGNED

The Crosstalk Between Red And White Blood Cells: The Case Of Fish

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EC-Contrib. €

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 BLOODCELLSCROSSTALK project word cloud

Explore the words cloud of the BLOODCELLSCROSSTALK project. It provides you a very rough idea of what is the project "BLOODCELLSCROSSTALK" about.

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Project "BLOODCELLSCROSSTALK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE 

Organization address
address: AVENIDA DE LA UNIVERSIDAD S-N
city: ELCHE
postcode: 3202
website: www.umh.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://ibmc.umh.es/antiviral-immunology-en.asp
 Total cost 1˙823˙250 €
 EC max contribution 1˙823˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE ES (ELCHE) coordinator 1˙823˙250.00

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 Project objective

Fish are the phylogenetically oldest vertebrate group with an immune system with clear similarities to the immune system of mammals. However, it is an actual matter of fact that the current knowledge of the fish immune system seems to lack the key piece to complete the puzzle. In 1953 Nelson described a new role of human red blood cells (RBCs) which would go beyond the simple transport of O2 to the tissues. This new role, involved in the defence against microbes, described the antibody and complement-dependent binding of microbial immune complexes to RBCs. Regardless of the importance of this finding in the field of microbial infection, this phenomenon has been poorly evaluated. Just recently, a set of biological processes relevant to immunity have been described in the RBCs of a diverse group of organisms, which include: pathogen recognition, pathogen binding and clearance and cytokines production. Furthermore, it has been demonstrated that nucleated erythrocytes from fish and avian species develop specific responses to different pathogen associated molecular patterns and produce soluble factors that modulate leukocyte activity. In the light of these pieces of evidences, and in an attempt to improve the knowledge of the immune mechanism(s) responsible for fish protection against viral infections, we raised the question: could nucleated fish erythrocytes be the key mediators of the antiviral responses? To answer this question we decided to focus our project on the evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. For that a working model composed of the rainbow trout and the viral haemorrhagic septicaemia virus (VHSV) was chosen, being the objectives of the project to evaluate: i) the implication trout RBCs (tRBCs) in the clearance of VHSV, and ii) the involvement of tRBCs in the blood transportation of the glycoprotein G of VHSV (GVHSV), the antigen encoded by the DNA vaccine.

 Publications

year authors and title journal last update
List of publications.
2019 I. Nombela, M. Lopez-Lorigados, S. Puente-Marin, V. Chico, S. Ciordia, M.C. Mena, J. Coll, L. Mercado, L. Perez, M. Ortega-Villaizan
Transcriptome and proteome analyses of red blood cells from rainbow trout challenged with viral haemorrhagic septicaemia virus
published pages: 440, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.206
Fish & Shellfish Immunology 91 2020-01-20
2019 B. Morales-Lange, F. Guzmán, L. Lagos, M. Øverland, I. Nombela, M. Ortega-Villaizán, M. Imarai, K. Maisey, V. Wong, L. Mercado
Cell surface markers for the identification of subpopulations of splenocytes from salmonids
published pages: 395, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.086
Fish & Shellfish Immunology 91 2020-01-20
2019 V. Chico, M. Salvador-Mira, I. Nombela, S. Puente-Marin, S. Ciordi, M.C. Mena, L. Perez, J. Coll, F. Guzman, J. Encinar, L. Mercado, M. Ortega-Villaizan
IFIT5 participates in the antiviral mechanisms of rainbow trout red blood cells
published pages: 469, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.284
Fish & Shellfish Immunology 91 2020-01-20
2019 V. Chico, S. Puente-Marin, I. Nombela, S. Ciordia, M.C. Mena, B. Carracedo, A. Villena, L. Mercado, J. Coll, M. Ortega-Villaizan
Rainbow trout shape-shifted red blood cells
published pages: 408, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.122
Fish & Shellfish Immunology 91 2020-01-20
2019 Nombela, Lopez-Lorigados, Salvador-Mira, Puente-Marin, Chico, Ciordia, Mena, Mercado, Coll, Perez, Ortega-Villaizan
Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets
published pages: 63, ISSN: 2076-393X, DOI: 10.3390/vaccines7030063
Vaccines 7/3 2020-01-20
2019 S. Puente-Marin, I. Nombela, V. Chico, S. Ciordia, M.C. Mena, J. Coll, L. Mercado, M. Ortega-Villaizán
Potential role of rainbow trout red blood cells as mediators in the immune response induced by DNA vaccines
published pages: 425, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.164
Fish & Shellfish Immunology 91 2020-01-20
2019 M. Salvador-Mira, V. Chico, I. Nombela, S. Puente-Marin, S. Ciordia, M.C. Mena, L. Mercado, M. Ortega-Villaizan
NKEF, an antiviral protein involved in the immune response of rainbow trout red blood cells
published pages: 409, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2019.04.123
Fish & Shellfish Immunology 91 2020-01-20
2019 Sara Puente-Marin, Rosemary Thwaite, Luis Mercado, Julio Coll, Nerea Roher, Maria Del Mar Ortega-Villaizan
Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFα and a G-VHSV Fragment
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01055
Frontiers in Immunology 10 2020-01-20
2018 Sara Puente-Marin, Iván Nombela, Sergio Ciordia, María Mena, Verónica Chico, Julio Coll, María Ortega-Villaizan
In Silico Functional Networks Identified in Fish Nucleated Red Blood Cells by Means of Transcriptomic and Proteomic Profiling
published pages: 202, ISSN: 2073-4425, DOI: 10.3390/genes9040202
Genes 9/4 2020-01-20
2017 Ivan Nombela, Aurora Carrion, Sara Puente-Marin, Verónica Chico, Luis Mercado, Luis Perez, Julio Coll, Maria del Mar Ortega-Villaizan
Infectious pancreatic necrosis virus triggers antiviral immune response in rainbow trout red blood cells, despite not being infective
published pages: 1968, ISSN: 2046-1402, DOI: 10.12688/f1000research.12994.2
F1000Research 6 2020-01-20
2018 Ivan Nombela, Maria del Mar Ortega-Villaizan
Nucleated red blood cells: Immune cell mediators of the antiviral response
published pages: e1006910, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006910
PLOS Pathogens 14/4 2020-01-20
2017 Ivan Nombela, Sara Puente-Marin, Veronica Chico, Luis Mercado, Luis Perez, Julio M. Coll, Amparo Estepa, Maria del Mar Ortega-Villaizan
Fish red blood cells halted VHSV and IPNV infections together with mounting antiviral immune responses
published pages: , ISSN: , DOI:
10TH INTERNATIONAL SYMPOSIUM ON VIRUSES OF LOWER VERTEBRATES (ISVLV), Budapest, Hungary 2020-01-20
2017 Sara Puente, Ivan Nombela, Veronica Chico, Julio Coll, Luis Mercado, Maria del Mar Ortega-Villaizán
RNA-SEQ OF RAINBOW TROUT RBCs TRANSFECTED WITH A DNA VACCINE IN VITRO SHOWS A POTENTIAL ROLE OF TROUT RBCs AS MEDIATORS IN THE IMMUNE RESPONSE INDUCED BY DNA VACCINES IN FISH.
published pages: , ISSN: , DOI:
2017 International Society of Vaccines. Annual Congress 5th‐7th October 2017, Institut Pasteur, Paris, France 2020-01-20
2017 Ivan Nombela, Sara Puente-Marin, Veronica Chico, Alberto J. Villena, Begoña Carracedo, Sergio Ciordia, Maria Carmen Mena, Luis Mercado, Luis Perez, Julio Coll, Amparo Estepa, Maria del Mar Ortega-Villaizan
Identification of diverse defense mechanisms in rainbow trout red blood cells in response to halted replication of VHS virus
published pages: 1958, ISSN: 2046-1402, DOI: 10.12688/f1000research.12985.2
F1000Research 6 2020-01-20
2017 Verónica Chico,Ivan Nombela, Sara Puente-Marín, Sergio Ciordia, Maria Carmen Mena, Julio Coll, Maria del Mar Ortega-Villaizan
Proteomic study of VHSV infected trout RBCs
published pages: , ISSN: , DOI:
10TH INTERNATIONAL SYMPOSIUM ON VIRUSES OF LOWER VERTEBRATES (ISVLV), Budapest, Hungary 2020-01-20
2018 Verónica Chico, Sara Puente-Marin, Iván Nombela, Sergio Ciordia, María Mena, Begoña Carracedo, Alberto Villena, Luis Mercado, Julio Coll, María Ortega-Villaizan
Shape-Shifted Red Blood Cells: A Novel Red Blood Cell Stage?
published pages: 31, ISSN: 2073-4409, DOI: 10.3390/cells7040031
Cells 7/4 2020-01-20
2018 Sara Puente-Marin, Ivan Nombela, Veronica Chico, Sergio Ciordia, Maria Carmen Mena, Julio Coll, Luis Mercado, Maria Del Mar Ortega-Villaizan
Rainbow Trout Erythrocytes ex vivo Transfection With a DNA Vaccine Encoding VHSV Glycoprotein G Induces an Antiviral Immune Response
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02477
Frontiers in Immunology 9 2020-01-20
2019 Ivan Nombela, Ricardo Requena-Platek, Byron Morales-Lange, Veronica Chico, Sara Puente-Marin, Sergio Ciordia, Maria Carmen Mena, Julio Coll, Luis Perez, Luis Mercado, Maria del Mar Ortega-Villaizan
Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers
published pages: 386, ISSN: 2073-4409, DOI: 10.3390/cells8050386
Cells 8/5 2020-01-20
2019 Veronica Chico, Maria Elizabhet Salvador-Mira, Ivan Nombela, Sara Puente-Marin, Sergio Ciordia, María Carmen Mena, Luis Perez, Julio Coll, Fanny Guzman, Jose Antonio Encinar, Luis Mercado, Maria del Mar Ortega-Villaizan
IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00613
Frontiers in Immunology 10 2020-01-20
2019 Myung-Hwa Jung, Verónica Chico, Sergio Ciordia, Maria Carmen Mena, Sung-Ju Jung, Maria Del Mar Ortega-Villaizan
The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00160
Frontiers in Immunology 10 2020-01-20
2019 Puente-Marin, Nombela, Chico, Ciordia, Mena, Perez, Coll, Ortega-Villaizan
Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish
published pages: 60, ISSN: 2076-393X, DOI: 10.3390/vaccines7030060
Vaccines 7/3 2020-01-20

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