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EMTECS

Electrophile-Mediated Three-Component Enantiospecific Cross-Couplings

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EMTECS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.chm.bris.ac.uk/org/aggarwal/publications.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2017-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 195˙454.00

Map

 Project objective

One of the most challenging aspects of Suzuki-Miyaura reactions is the stereospecific cross-coupling of sp3 substituted boronic esters with aryl halides. Recently, the host group developed a metal-free, stereospecific cross-coupling reaction of chiral alkyl boronates with electron-rich aromatics, promoted by the use of electrophilic oxidants. This proposal seeks to substantially extend this cross-coupling chemistry through the application of a range of different electrophiles that will not only mediate the cross-coupling process, but also remain in the final product, creating multiple carbon–carbon bonds stereospecifically. In particular, the application of electrophilic organometallic species will be investigated so as to take advantage of the power of metal catalysts in the formation of carbon–carbon bonds. Through the use of this strategy, doubly functionalised enantiopure aromatic compounds may be formed in a very efficient three-component coupling process that utilises readily accessible enantiopure alkyl boronic esters, electron-rich aromatics and catalytically generated organometallic electrophiles.

 Publications

year authors and title journal last update
List of publications.
2017 Yahui Wang, Adam Noble, Christopher Sandford, Varinder K. Aggarwal
Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans
published pages: 1810-1814, ISSN: 1433-7851, DOI: 10.1002/anie.201611058
Angewandte Chemie International Edition 56/7 2019-07-22
2016 Yahui Wang, Adam Noble, Eddie L. Myers, Varinder K. Aggarwal
Enantiospecific Alkynylation of Alkylboronic Esters
published pages: 4270-4274, ISSN: 1433-7851, DOI: 10.1002/anie.201600599
Angewandte Chemie International Edition 55/13 2019-07-22

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