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AutophagosomeSealing SIGNED

Ymr1 role in the Atg proteins release from complete autophagosomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AutophagosomeSealing project word cloud

Explore the words cloud of the AutophagosomeSealing project. It provides you a very rough idea of what is the project "AutophagosomeSealing" about.

stress    organelles    inflammatory    realization    diseases    action    professional    experimental    site    host    phagophore    double    pas    compounds    cell    combination    illnesses    benefit    proteins    pathophysiology    perspective    phosphatase    conceptual    degradation    specialized    survival    unknown    multiple    bases    found    diversity    phosphate    microscopy    model    regulate    health    yeast    concerted    fluorescence    location    autoimmune    molecular    malignancies    destruction    elucidate    cardiovascular    largely    muscular    membrane    vesicles    atg    pathogens    independence    aggregates    human    starting    ymr1    formed    techniques    edge    despite    regulation    assembly    plays    intracellular    phosphatidylinositol    dephosphorylating    therapies    biochemistry    autophagosomes    laboratory    electron    protein    autophagy    structures    neurodegenerative    sequestered    biology    regulates    advantages    maturity    cutting    mechanism    chronic    invading    reinforce   

Project "AutophagosomeSealing" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://cellbiology.umcg.nl/groups/reggiorigroup/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 177˙598.00

Map

 Project objective

Autophagy is one of the major intracellular degradation processes and it is essential for cell survival in multiple stress conditions. As a result, this pathway plays a key role in the pathophysiology of numerous illnesses including neurodegenerative, cardiovascular, chronic inflammatory, muscular and autoimmune diseases, and some malignancies. Structures targeted to destruction such as protein aggregates, organelles and invading pathogens are sequestered into double-membrane vesicles called autophagosomes. Autophagosomes are formed through the concerted action of the autophagy-related (Atg) proteins at a site specialized location known as the phagophore assembly site (PAS). Despite this knowledge, the mechanism and regulation of autophagy remain largely unknown. The host laboratory has found that Ymr1, a phosphatase dephosphorylating phosphatidylinositol-3-phosphate, plays a key role in the regulation of autophagy. The main objective of this project is to elucidate the mechanism through which Ymr1 regulates autophagy. To achieve this goal, the applicant will exploit the experimental advantages of the yeast model and use in combination cutting-edge techniques in molecular biology, biochemistry, fluorescence microscopy and electron microscopy. The results will advance our knowledge on autophagy and in a long-term perspective they will provide the conceptual bases for the development of therapies or compounds aimed to regulate autophagy to the benefit of human health. Through the realization of the project, the applicant will strongly reinforce his professional maturity, diversity and independence, essential for starting his own research activity.

 Publications

year authors and title journal last update
List of publications.
2017 Susana Abreu, Franziska Kriegenburg, Rubén Gómez‐Sánchez, Muriel Mari, Jana Sánchez‐Wandelmer, Mads Skytte Rasmussen, Rodrigo Soares Guimarães, Bettina Zens, Martina Schuschnig, Ralph Hardenberg, Matthias Peter, Terje Johansen, Claudine Kraft, Sascha Martens, Fulvio Reggiori
Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation
published pages: 765-780, ISSN: 1469-221X, DOI: 10.15252/embr.201643146
EMBO reports 18/5 2019-06-13
2017 Jana Sánchez-Wandelmer, Franziska Kriegenburg, Sabrina Rohringer, Martina Schuschnig, Rubén Gómez-Sánchez, Bettina Zens, Susana Abreu, Ralph Hardenberg, David Hollenstein, Jieqiong Gao, Christian Ungermann, Sascha Martens, Claudine Kraft, Fulvio Reggiori
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00302-3
Nature Communications 8/1 2019-06-13

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