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AutophagosomeSealing SIGNED

Ymr1 role in the Atg proteins release from complete autophagosomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AutophagosomeSealing project word cloud

Explore the words cloud of the AutophagosomeSealing project. It provides you a very rough idea of what is the project "AutophagosomeSealing" about.

techniques    illnesses    microscopy    assembly    electron    survival    pas    reinforce    cutting    diversity    phosphatidylinositol    inflammatory    intracellular    location    plays    realization    pathogens    human    unknown    regulation    ymr1    vesicles    atg    degradation    chronic    yeast    sequestered    perspective    site    laboratory    combination    cardiovascular    regulate    compounds    fluorescence    muscular    regulates    host    despite    biology    malignancies    diseases    phosphatase    multiple    therapies    phagophore    autoimmune    cell    largely    starting    conceptual    benefit    double    mechanism    dephosphorylating    organelles    formed    aggregates    molecular    phosphate    biochemistry    neurodegenerative    destruction    autophagosomes    pathophysiology    membrane    experimental    action    concerted    bases    health    autophagy    invading    edge    specialized    stress    advantages    found    professional    maturity    proteins    independence    elucidate    model    structures    protein   

Project "AutophagosomeSealing" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://cellbiology.umcg.nl/groups/reggiorigroup/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 177˙598.00

Map

 Project objective

Autophagy is one of the major intracellular degradation processes and it is essential for cell survival in multiple stress conditions. As a result, this pathway plays a key role in the pathophysiology of numerous illnesses including neurodegenerative, cardiovascular, chronic inflammatory, muscular and autoimmune diseases, and some malignancies. Structures targeted to destruction such as protein aggregates, organelles and invading pathogens are sequestered into double-membrane vesicles called autophagosomes. Autophagosomes are formed through the concerted action of the autophagy-related (Atg) proteins at a site specialized location known as the phagophore assembly site (PAS). Despite this knowledge, the mechanism and regulation of autophagy remain largely unknown. The host laboratory has found that Ymr1, a phosphatase dephosphorylating phosphatidylinositol-3-phosphate, plays a key role in the regulation of autophagy. The main objective of this project is to elucidate the mechanism through which Ymr1 regulates autophagy. To achieve this goal, the applicant will exploit the experimental advantages of the yeast model and use in combination cutting-edge techniques in molecular biology, biochemistry, fluorescence microscopy and electron microscopy. The results will advance our knowledge on autophagy and in a long-term perspective they will provide the conceptual bases for the development of therapies or compounds aimed to regulate autophagy to the benefit of human health. Through the realization of the project, the applicant will strongly reinforce his professional maturity, diversity and independence, essential for starting his own research activity.

 Publications

year authors and title journal last update
List of publications.
2017 Susana Abreu, Franziska Kriegenburg, Rubén Gómez‐Sánchez, Muriel Mari, Jana Sánchez‐Wandelmer, Mads Skytte Rasmussen, Rodrigo Soares Guimarães, Bettina Zens, Martina Schuschnig, Ralph Hardenberg, Matthias Peter, Terje Johansen, Claudine Kraft, Sascha Martens, Fulvio Reggiori
Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation
published pages: 765-780, ISSN: 1469-221X, DOI: 10.15252/embr.201643146
EMBO reports 18/5 2019-06-13
2017 Jana Sánchez-Wandelmer, Franziska Kriegenburg, Sabrina Rohringer, Martina Schuschnig, Rubén Gómez-Sánchez, Bettina Zens, Susana Abreu, Ralph Hardenberg, David Hollenstein, Jieqiong Gao, Christian Ungermann, Sascha Martens, Claudine Kraft, Fulvio Reggiori
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00302-3
Nature Communications 8/1 2019-06-13

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The information about "AUTOPHAGOSOMESEALING" are provided by the European Opendata Portal: CORDIS opendata.

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