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CircaDopamine

The Role of Dopamine in the Regulation of Sleep and Circadian Rhythms

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CircaDopamine project word cloud

Explore the words cloud of the CircaDopamine project. It provides you a very rough idea of what is the project "CircaDopamine" about.

first    patients    hosting    vitro    multiunit    neurons    circada    sleep    motor    prevalent    cortical    disorders    regulation    progressive    functional    fundamental    insights    striatal    therapeutic    dopamine    synchronizing    academic    lacks    model    parkinson    per2    dependent    selective    polysomnography    bioluminescence    researcher    shows    receptor    age    electrophysiology    competences    alterations    symptoms    correlates    rhythms    clamp    patch    question    mice    models    molecular    driving    career    psychiatric    significantly    mitopark    holds    debilitating    ph    neurodegenerative    neurological    neurotransmission    alleviate    translational    multiple    oscillations    gene    inspired    regulates    laboratory    diseases    mouse    modulate    performed    strategies    vivo    perturbations    investigation    wakefulness    selectively    originate    disease    combined    mechanisms    electrophysiological    da    pd    behavior    transgenic    collectively    suffering    drugs    neurodegeneration    circadian    clock   

Project "CircaDopamine" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.lumc.nl/org/moleculaire-celbiologie/medewerkers/KarimFifel
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 177˙598.00

Map

 Project objective

Alterations in sleep/wakefulness behavior are among the most debilitating and highly prevalent non-motor symptoms of many neurological and psychiatric disorders that originate from perturbations of the Dopamine (DA) system. Currently, no effective therapeutic strategies are available to alleviate these symptoms. Inspired by my Ph.D results, the current proposal aims to investigate in detail the role of dopamine in the regulation of sleep and circadian rhythms. The main question under investigation is; By what mechanisms DA regulates sleep and circadian rhythms and how are these affected in diseases (such as Parkinson)? Two transgenic mouse models will be used; the first model (MitoPark) shows, like in Parkinson’s disease (PD) patients, a progressive age-dependent neurodegeneration of DA neurons. The second model (CircaDA) lacks functional clock gene oscillations selectively in DA neurons. Using polysomnography in MitoPark mice, a detailed investigation of the consequences of DA loss on sleep regulation will be performed. In-vivo multiunit electrophysiology will be used in both mouse models to study the role of the circadian changes in DA neurotransmission in driving and/or synchronizing the electrophysiological properties of striatal and cortical neurons. Finally, selective DA receptor drugs will be combined with in-vitro patch clamp electrophysiology and in-vitro Per2-bioluminescence to investigate the molecular pathways used by DA to modulate multiple electrophysiological correlates of clock gene oscillations. Collectively, this proposal holds promising fundamental and translational insights for sleep problems experienced by patients suffering from DA-related disorders and is expected to significantly contribute in fostering the academic career of the researcher and the competences of the hosting laboratory in Neurodegenerative diseases.

 Publications

year authors and title journal last update
List of publications.
2018 Karim Fifel, Johanna H. Meijer, Tom Deboer
Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25770-5
Scientific Reports 8/1 2019-07-23
2018 Karim Fifel, Aleksandar Videnovic
Light Therapy in Parkinson’s Disease: Towards Mechanism-Based Protocols
published pages: 252-254, ISSN: 0166-2236, DOI: 10.1016/j.tins.2018.03.002
Trends in Neurosciences 41/5 2019-07-23
2018 Fifel K
Readiness Potential and Neuronal Determinism: New Insights on Libet Experiment
published pages: , ISSN: 1529-2401, DOI: 10.1523/JNEUROSCI.3136-17.2017
J Neurosci 2019-07-23
2018 Marjolein Schoonakker, Johanna H Meijer, Tom Deboer, Karim Fifel
Heterogeneity in the circadian and homeostatic modulation of multiunit activity in the lateral hypothalamus
published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsy051
Sleep 41/6 2019-07-23
2018 Karim Fifel, Johanna H. Meijer, Tom Deboer
Long-term effects of sleep deprivation on neuronal activity in four hypothalamic areas
published pages: 54-63, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2017.10.005
Neurobiology of Disease 109 2019-07-23
2017 Karim Fifel
Alterations of the circadian system in Parkinson\'s disease patients
published pages: 682-692, ISSN: 0885-3185, DOI: 10.1002/mds.26865
Movement Disorders 32/5 2019-07-23

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