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CircaDopamine

The Role of Dopamine in the Regulation of Sleep and Circadian Rhythms

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 CircaDopamine project word cloud

Explore the words cloud of the CircaDopamine project. It provides you a very rough idea of what is the project "CircaDopamine" about.

neurotransmission    striatal    patch    collectively    alleviate    circadian    lacks    multiple    regulates    neurological    academic    patients    polysomnography    insights    diseases    hosting    strategies    mouse    holds    pd    electrophysiology    model    inspired    gene    vitro    age    parkinson    cortical    circada    ph    neurodegeneration    dependent    modulate    sleep    correlates    mice    symptoms    disorders    behavior    multiunit    driving    oscillations    dopamine    originate    neurodegenerative    researcher    transgenic    rhythms    psychiatric    alterations    vivo    mitopark    receptor    selective    mechanisms    electrophysiological    functional    fundamental    performed    da    drugs    competences    laboratory    wakefulness    disease    significantly    bioluminescence    investigation    prevalent    suffering    first    clock    neurons    therapeutic    combined    clamp    regulation    synchronizing    progressive    debilitating    models    career    motor    molecular    translational    shows    selectively    per2    perturbations    question   

Project "CircaDopamine" data sheet

The following table provides information about the project.

Coordinator		 ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Netherlands [NL]
 Project website https://www.lumc.nl/org/moleculaire-celbiologie/medewerkers/KarimFifel
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 177˙598.00

Map

 Project objective

Alterations in sleep/wakefulness behavior are among the most debilitating and highly prevalent non-motor symptoms of many neurological and psychiatric disorders that originate from perturbations of the Dopamine (DA) system. Currently, no effective therapeutic strategies are available to alleviate these symptoms. Inspired by my Ph.D results, the current proposal aims to investigate in detail the role of dopamine in the regulation of sleep and circadian rhythms. The main question under investigation is; By what mechanisms DA regulates sleep and circadian rhythms and how are these affected in diseases (such as Parkinson)? Two transgenic mouse models will be used; the first model (MitoPark) shows, like in Parkinson’s disease (PD) patients, a progressive age-dependent neurodegeneration of DA neurons. The second model (CircaDA) lacks functional clock gene oscillations selectively in DA neurons. Using polysomnography in MitoPark mice, a detailed investigation of the consequences of DA loss on sleep regulation will be performed. In-vivo multiunit electrophysiology will be used in both mouse models to study the role of the circadian changes in DA neurotransmission in driving and/or synchronizing the electrophysiological properties of striatal and cortical neurons. Finally, selective DA receptor drugs will be combined with in-vitro patch clamp electrophysiology and in-vitro Per2-bioluminescence to investigate the molecular pathways used by DA to modulate multiple electrophysiological correlates of clock gene oscillations. Collectively, this proposal holds promising fundamental and translational insights for sleep problems experienced by patients suffering from DA-related disorders and is expected to significantly contribute in fostering the academic career of the researcher and the competences of the hosting laboratory in Neurodegenerative diseases.

 Publications

year authors and title journal last update
List of publications.
2018 Karim Fifel, Johanna H. Meijer, Tom Deboer
Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25770-5 		Scientific Reports 8/1 2019-07-23
2018 Karim Fifel, Aleksandar Videnovic
Light Therapy in Parkinson’s Disease: Towards Mechanism-Based Protocols
published pages: 252-254, ISSN: 0166-2236, DOI: 10.1016/j.tins.2018.03.002 		Trends in Neurosciences 41/5 2019-07-23
2018 Fifel K
Readiness Potential and Neuronal Determinism: New Insights on Libet Experiment
published pages: , ISSN: 1529-2401, DOI: 10.1523/JNEUROSCI.3136-17.2017 		J Neurosci 2019-07-23
2018 Marjolein Schoonakker, Johanna H Meijer, Tom Deboer, Karim Fifel
Heterogeneity in the circadian and homeostatic modulation of multiunit activity in the lateral hypothalamus
published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsy051 		Sleep 41/6 2019-07-23
2018 Karim Fifel, Johanna H. Meijer, Tom Deboer
Long-term effects of sleep deprivation on neuronal activity in four hypothalamic areas
published pages: 54-63, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2017.10.005 		Neurobiology of Disease 109 2019-07-23
2017 Karim Fifel
Alterations of the circadian system in Parkinson\'s disease patients
published pages: 682-692, ISSN: 0885-3185, DOI: 10.1002/mds.26865 		Movement Disorders 32/5 2019-07-23

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