EU H2020 Project "CIRCADOPAMINE (The Role of Dopamine in the Regulation of Sleep and Circadian Rhythms)": description, partecipants, costs and EC-fundings

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CircaDopamine project word cloud

Explore the words cloud of the CircaDopamine project. It provides you a very rough idea of what is the project "CircaDopamine" about.

therapeutic hosting perturbations disease vitro model insights originate significantly psychiatric patients researcher academic functional models multiunit per2 selectively holds bioluminescence disorders collectively ph multiple molecular clamp combined inspired progressive receptor mechanisms vivo laboratory pd circada cortical suffering alterations parkinson fundamental question behavior investigation electrophysiological dependent gene sleep synchronizing oscillations patch alleviate performed neurodegenerative electrophysiology age neurotransmission competences selective neurological translational diseases wakefulness mitopark career correlates lacks mice clock neurodegeneration driving strategies debilitating regulates neurons drugs modulate symptoms transgenic da dopamine striatal motor shows first circadian rhythms mouse regulation polysomnography prevalent

Project "CircaDopamine" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.lumc.nl/org/moleculaire-celbiologie/medewerkers/KarimFifel
Total cost	177˙598 €
EC max contribution	177˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2017-06-30

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH ZIEKENHUIS LEIDEN	NL (LEIDEN)	coordinator	177˙598.00

ACADEMISCH ZIEKENHUIS LEIDEN

NL (LEIDEN)

coordinator

177˙598.00

Project objective

Alterations in sleep/wakefulness behavior are among the most debilitating and highly prevalent non-motor symptoms of many neurological and psychiatric disorders that originate from perturbations of the Dopamine (DA) system. Currently, no effective therapeutic strategies are available to alleviate these symptoms. Inspired by my Ph.D results, the current proposal aims to investigate in detail the role of dopamine in the regulation of sleep and circadian rhythms. The main question under investigation is; By what mechanisms DA regulates sleep and circadian rhythms and how are these affected in diseases (such as Parkinson)? Two transgenic mouse models will be used; the first model (MitoPark) shows, like in Parkinson’s disease (PD) patients, a progressive age-dependent neurodegeneration of DA neurons. The second model (CircaDA) lacks functional clock gene oscillations selectively in DA neurons. Using polysomnography in MitoPark mice, a detailed investigation of the consequences of DA loss on sleep regulation will be performed. In-vivo multiunit electrophysiology will be used in both mouse models to study the role of the circadian changes in DA neurotransmission in driving and/or synchronizing the electrophysiological properties of striatal and cortical neurons. Finally, selective DA receptor drugs will be combined with in-vitro patch clamp electrophysiology and in-vitro Per2-bioluminescence to investigate the molecular pathways used by DA to modulate multiple electrophysiological correlates of clock gene oscillations. Collectively, this proposal holds promising fundamental and translational insights for sleep problems experienced by patients suffering from DA-related disorders and is expected to significantly contribute in fostering the academic career of the researcher and the competences of the hosting laboratory in Neurodegenerative diseases.

Publications

List of publications.
year	authors and title	journal	last update
2018	Karim Fifel, Johanna H. Meijer, Tom Deboer Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25770-5	Scientific Reports 8/1	2019-07-23
2018	Karim Fifel, Aleksandar Videnovic Light Therapy in Parkinsonâ€™s Disease: Towards Mechanism-Based Protocols published pages: 252-254, ISSN: 0166-2236, DOI: 10.1016/j.tins.2018.03.002	Trends in Neurosciences 41/5	2019-07-23
2018	Fifel K Readiness Potential and Neuronal Determinism: New Insights on Libet Experiment published pages: , ISSN: 1529-2401, DOI: 10.1523/JNEUROSCI.3136-17.2017	J Neurosci	2019-07-23
2018	Marjolein Schoonakker, Johanna H Meijer, Tom Deboer, Karim Fifel Heterogeneity in the circadian and homeostatic modulation of multiunit activity in the lateral hypothalamus published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsy051	Sleep 41/6	2019-07-23
2018	Karim Fifel, Johanna H. Meijer, Tom Deboer Long-term effects of sleep deprivation on neuronal activity in four hypothalamic areas published pages: 54-63, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2017.10.005	Neurobiology of Disease 109	2019-07-23
2017	Karim Fifel Alterations of the circadian system in Parkinson\'s disease patients published pages: 682-692, ISSN: 0885-3185, DOI: 10.1002/mds.26865	Movement Disorders 32/5	2019-07-23

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