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HYBRIPORE

Hybrid DNA-protein nanopores with large and uniform pore sizes

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HYBRIPORE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

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 Project objective

This proposal aims at developing novel hybrid DNA-protein nanopores with well-defined, uniform channel sizes, to advance fundamental studies on transport across membranes and to enable the development of new biosensors and progress towards creating artificial cells and tissues. Currently used protein nanopores either have a limited cargo capacity, which is set by their internal diameter, or they are heterogeneous in size and sometimes incompletely assembled. I propose to use DNA origami nanostructures as scaffolds for barrel- and ring-forming peptides of alpha-haemolysin and ClyA/Wza to create hybrid pores with larger and uniform pore sizes. These hybrid pores have the advantage that they are fully biocompatible and retain the potential for genetic and chemical engineering at the level of the DNA and proteins through the use of nucleotide recognition sequences and functionalised amino acid residues. By systematic characterisation of the hybrid nanopores in the controlled environment of droplet interface bilayers using single-channel current recordings and fluorescent detection of transport across membranes, the proposed hybrid nanopores will provide valuable insights into membrane transport and potential applications in biotechnology and medicine.

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The information about "HYBRIPORE" are provided by the European Opendata Portal: CORDIS opendata.

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