Opendata, web and dolomites

ThymusTolerance SIGNED

Delineation of molecular mechanisms underlying the establishment and breakdown of immunological tolerance in the thymus

Total Cost €


EC-Contrib. €






 ThymusTolerance project word cloud

Explore the words cloud of the ThymusTolerance project. It provides you a very rough idea of what is the project "ThymusTolerance" about.

shaped    determinants    ctec    strikingly    molecular    identification    self    foreign    primary    gene    medullary    separate    outstanding    tecs    mtec    regulator    dependent    wish    establishment    generation    treg    negative    aire    responsible    characterization    components    antigens    toolbox    stages    govern    immature    epithelial    elusive    dramatic    regulated    pivotal    lymphocytes    promiscuously    mature    reactive    tsa    clones    promiscuous    questions    shape    cells    organogenesis    of    express    patients    regulatory    antigen    autoimmunity    lymphoid    educated    adaptive    body    cell    central    recognizing    herein    genes    tec    screening    play    progress    tissue    tolerance    interdisciplinary    organ    data    mice    thymic    single    foxp3    delineation    cortical    published    unpublished    lab    transcriptional    utilize    fundamental    lineages    expression    thousands    critical    deficiency    mechanisms    capacity    immunity    preliminary    mtecs    thymus    tolerating    ctecs    almost    answers    breakdown    immunological    integral    repertoire    thymocytes    mainly    human    underlying   

Project "ThymusTolerance" data sheet

The following table provides information about the project.


Organization address
address: HERZL STREET 234
postcode: 7610001

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙220˙000 €
 EC max contribution 2˙220˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙220˙000.00


 Project objective

Central tolerance is shaped in the thymus, a primary lymphoid organ, where immature T lymphocytes are “educated” into mature cells, capable of recognizing foreign antigens, while tolerating the body’s own components. This process is driven mainly by two separate lineages of thymic epithelial cells (TECs), the cortical (cTEC) and the medullary (mTEC). While cTECs are critical at the early stages of T cell development, mTECs play a pivotal role in negative selection of self-reactive thymocytes and the generation of Foxp3 regulatory T (Treg) cells. Crucial to the key role of mTECs in the screening of self-reactive T cell clones, is their unique capacity to promiscuously express and present almost all self-antigens, including thousands of tissue-specific antigen (TSA) genes. Strikingly, the expression of most of this TSA repertoire in mTECs is regulated by a single transcriptional regulator called Aire. Indeed, Aire deficiency in mice and human patients results to multi-organ autoimmunity. Although there has been dramatic progress in our understanding of how thymic epithelial cells shape and govern the establishment of adaptive immunity and of immunological self-tolerance, there are still several outstanding questions with no comprehensive answers. Therefore, in the research proposed herein, we wish to provide more comprehensive answers to these still elusive, but very fundamental questions. Specifically we will aim at: 1.) Delineation of molecular mechanisms controlling TEC development and thymus organogenesis; 2.) Delineation of molecular mechanisms underlying promiscuous gene expression in the thymus; 3.) Identification and characterization of molecular determinants responsible for the breakdown of thymus-dependent self-tolerance. To this end, we will build upon our recently published data, as well as unpublished preliminary data and utilize several state-of-the-art and interdisciplinary approaches, which have become an integral part of our lab’s toolbox.


year authors and title journal last update
List of publications.
2017 Ayelet Avin, Maayan Levy, Ziv Porat, Jakub Abramson
Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01808-6
Nature Communications 8/1 2019-06-06
2018 Chamutal Bornstein, Shir Nevo, Amir Giladi, Noam Kadouri, Marie Pouzolles, François Gerbe, Eyal David, Alice Machado, Anna Chuprin, Beáta Tóth, Ori Goldberg, Shalev Itzkovitz, Naomi Taylor, Philippe Jay, Valérie S. Zimmermann, Jakub Abramson, Ido Amit
Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells
published pages: 622-626, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0346-1
Nature 559/7715 2019-06-06
2019 Shir Nevo, Noam Kadouri, Jakub Abramson
Tuft cells: From the mucosa to the thymus
published pages: 1-9, ISSN: 0165-2478, DOI: 10.1016/j.imlet.2019.02.003
Immunology Letters 210 2019-06-06
2017 Jakub Abramson, Graham Anderson
Thymic Epithelial Cells
published pages: 85-118, ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-051116-052320
Annual Review of Immunology 35/1 2019-06-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "THYMUSTOLERANCE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "THYMUSTOLERANCE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


Economic Fluctuations, Productivity Growth and Stabilization Policies: A Keynesian Growth Perspective

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More