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Active implants

Active implants: Engineering microstructures of functional ceramics for stimulated bone growth

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Active implants project word cloud

Explore the words cloud of the Active implants project. It provides you a very rough idea of what is the project "Active implants" about.

stimulation bone cell influence osseogenesis microscopy force understand grain gained experiments exert form ceramic cells porosity surface cellular techniques materials mesoscopic replacement mechanical interfacial ceramics ingrowth biocompatibility utilizing healing quality vascular determined size unpoled macroscopic structure bonds electrically clarified biocompatible microstructural load bond accelerate responsible piezoelectric charges basis material implant lasting create vitro electrical employing alter morphology stimuli class pave electric structural pores local stimulate diffraction piezo implants poled

Project "Active implants" data sheet

The following table provides information about the project.

Coordinator	NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 website: www.ntnu.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Norway [NO]
Project website	https://cyclicpressure.wordpress.com/
Total cost	208˙400 €
EC max contribution	208˙400 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2017-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 website: www.ntnu.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TRONDHEIM)	coordinator	208˙400.00

Map

Project objective

The aim of this study is to develop piezoelectric ceramics for the use as bone replacement materials utilizing their piezoelectric behaviour to stimulate bone and vascular cell growth. The work is based on the finding that mechanical and electrical stimuli exert a strong influence on the osseogenesis on the cellular level. As piezoelectric ceramics develop electric surface charges under mechanical load it is expected that they accelerate the healing process and support the development of a strong bond between bone and implant. The quality of bone and vascular ingrowth is determined by various factors such as biocompatibility of the replacement material, surface morphology and electric surface states. Especially the porosity of the ceramic is of crucial importance as the pores have to be large enough and of open structure to allow ingrowth of both bone and vascular cells. However, increasing porosity is likely to alter the local piezoelectric behaviour and by this the local surface charges responsible for cell growth stimulation. To pave the way for the development of piezoelectric implants it is crucial to understand the influence of microstructural features such as porosity and grain size on the piezoelectric properties. I will approach this task by developing biocompatible ceramics with a wide range of microstructural characteristics. I will investigate the influence of porosity and grain size on a macroscopic scale using piezoelectric testing techniques, on a mesoscopic scale employing Piezo Force Microscopy and on the structural scale via diffraction studies. The biocompatibility as well as the influence of the piezoelectric behaviour on the osseogenesis will be clarified by in-vitro cell experiments on unpoled and electrically poled ceramics. The knowledge gained will form the basis for the development of a new class of implant materials exploiting the piezoelectric characteristics to improve the healing process and to create long lasting interfacial bonds.

Publications

List of publications.
year	authors and title	journal	last update
2017	Lyndsey M. Denis, Julia Glaum, Mark Hoffman, John E. Daniels, Ryan J. Hooper, Goknur Tutuncu, Jennifer S. Forrester, Jacob L. Jones Effect of mechanical depoling on piezoelectric properties of Na0.5Bi0.5TiO3â€“xBaTiO3 in the morphotropic phase boundary region published pages: , ISSN: 0022-2461, DOI: 10.1007/s10853-017-1616-2	Journal of Materials Science	2019-06-13
2017	Emily W. Yap, Julia Glaum, Jette Oddershede, John E. Daniels Effect of porosity on the ferroelectric and piezoelectric properties of(Ba0.85Ca0.15)(Zr0.1Ti0.9)O3 piezoelectric ceramics published pages: , ISSN: 1359-6462, DOI:	Scripta Materialia	2019-06-13

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The information about "ACTIVE IMPLANTS" are provided by the European Opendata Portal: CORDIS opendata.