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Active implants

Active implants: Engineering microstructures of functional ceramics for stimulated bone growth

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EC-Contrib. €

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Partnership

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Project "Active implants" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website https://cyclicpressure.wordpress.com/
 Total cost 208˙400 €
 EC max contribution 208˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 208˙400.00

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 Project objective

The aim of this study is to develop piezoelectric ceramics for the use as bone replacement materials utilizing their piezoelectric behaviour to stimulate bone and vascular cell growth. The work is based on the finding that mechanical and electrical stimuli exert a strong influence on the osseogenesis on the cellular level. As piezoelectric ceramics develop electric surface charges under mechanical load it is expected that they accelerate the healing process and support the development of a strong bond between bone and implant. The quality of bone and vascular ingrowth is determined by various factors such as biocompatibility of the replacement material, surface morphology and electric surface states. Especially the porosity of the ceramic is of crucial importance as the pores have to be large enough and of open structure to allow ingrowth of both bone and vascular cells. However, increasing porosity is likely to alter the local piezoelectric behaviour and by this the local surface charges responsible for cell growth stimulation. To pave the way for the development of piezoelectric implants it is crucial to understand the influence of microstructural features such as porosity and grain size on the piezoelectric properties. I will approach this task by developing biocompatible ceramics with a wide range of microstructural characteristics. I will investigate the influence of porosity and grain size on a macroscopic scale using piezoelectric testing techniques, on a mesoscopic scale employing Piezo Force Microscopy and on the structural scale via diffraction studies. The biocompatibility as well as the influence of the piezoelectric behaviour on the osseogenesis will be clarified by in-vitro cell experiments on unpoled and electrically poled ceramics. The knowledge gained will form the basis for the development of a new class of implant materials exploiting the piezoelectric characteristics to improve the healing process and to create long lasting interfacial bonds.

 Publications

year authors and title journal last update
List of publications.
2017 Lyndsey M. Denis, Julia Glaum, Mark Hoffman, John E. Daniels, Ryan J. Hooper, Goknur Tutuncu, Jennifer S. Forrester, Jacob L. Jones
Effect of mechanical depoling on piezoelectric properties of Na0.5Bi0.5TiO3–xBaTiO3 in the morphotropic phase boundary region
published pages: , ISSN: 0022-2461, DOI: 10.1007/s10853-017-1616-2
Journal of Materials Science 2019-06-13
2017 Emily W. Yap, Julia Glaum, Jette Oddershede, John E. Daniels
Effect of porosity on the ferroelectric and piezoelectric properties of(Ba0.85Ca0.15)(Zr0.1Ti0.9)O3 piezoelectric ceramics
published pages: , ISSN: 1359-6462, DOI:
Scripta Materialia 2019-06-13

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