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NIMBLIS SIGNED

Laser Induced Synthesis of Biocompatible Multifunctional Inorganic Nanoparticles: A Novel Route to Produce Multifunctional Contrast Agents for Early Diagnosis of Breast Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NIMBLIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://www.researchgate.net/project/Laser-Induced-Synthesis-of-Biocompatible-Multifunctional-Inorganic-Nanoparticles-A-Novel-Route-to-Produce-Multifunctional-Contrast-Agents-for-Early-Diagnosis-of-Br
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 166˙156.00

Map

 Project objective

The main goal of this IF research proposal is to produce novel nanoparticle-based multimodal contrast agents for their use in breast cancer diagnosis by combining Magnetic Resonance Imaging, Digital Mammography, X-ray Computed Tomography and Ultrasonography. In doing so, we will develop a new high-productivity strategy to synthesize multimodal hybrid nanoparticles, which consists in femtosecond-laser-induced-ablation of a metal plate immersed into a solvent containing chemicals, in combination with direct nanosecond-laser photolysis in solution of these chemicals. This research will be coupled to an in situ study of the high-productivity laser fabrication process and the analysis of the underlying mechanisms which allows the nucleation and growth of these hybrid nanoparticles. Moreover, we will analyze the structure, composition, physical and colloidal properties of the as-synthesized hybrid nanoparticles, as well as the in vitro performance of these nanoparticles as contrast agents in Magnetic Resonance Imaging, Ultrasonography and X-ray imaging techniques. We will also evaluate the citotoxicity of the as synthesized hybrid nanoparticles in normal cells and tumor breast cells lines. Finally, we will target these nanoparticles toward the human epidermal growth factor receptor 2 (HER2) which is overexpressed in breast cancers with a poor prognosis and higher disease recurrence, and we will evaluated in vitro the targeting ability of the obtained anti-HER2-nanoparticles conjugates for HER2 breast cancer cells.

 Publications

year authors and title journal last update
List of publications.
2016 N. Lasemi, U. Pacher, L.V. Zhigilei, O. Bomati-Miguel, W. Kautek
Laser Ablation of Metals in Liquid Contact
published pages: , ISSN: , DOI:
2017 E-MRS Spring: Book Abstract 2019-06-13
2016 W. Kautek, N. Lasemi, O. Bomati-Miguel, U. Pacher, C. Rentenberger, K. Richter, R. Lahoz
Laser Assisted Synthesis of Colloidal Nanoparticles in various Fluids
published pages: 13, ISSN: , DOI:
4TH CONFERENCE ON ADVANCED NANOPARTICLE GENERATION AND EXCITATION BY LASERS IN LIQUIDS (ANGEL): ABSTRACT BOOK 2019-06-13
2016 O. Bomati-Miguel, N. Lasemi, U. Pacher, R. Lahoz, C. Rentenberge, K. Richte, W. KauteK
Laser Assisted Synthesis of Colloidal Nanoparticles in various Fluids
published pages: , ISSN: , DOI:
EMN Meeting on Smart and Multifunctional Material. Abstract Book 2019-06-13
2016 N. Lasemi, R. Lahoz, K. Weiland, C. Rentenberger, G. Reisinger, K. Richter, W. Kautek, O. Bomati-Miguel.
METAL NANOPARTICLES SYNTHESIZED BY LASER ABLATION IN LIQUIDS OF MASSIVE METAL PLATES
published pages: , ISSN: , DOI:
2nd Erwin Schrödinger Symposium 2016 of the Erwin Schrödinger Society for Nanosciences: Abstract Book 2019-06-13
2016 R. Lahoz, N. Lasemi, V.V Lennikov, K. Weiland, A. Subotic, C. Rentenberger, G. Reisinger, K. Richter, G.F. de la Fuente, W. Kautek, O. Bomati-Miguel.
LASER ABLATION IN LIQUIDS SYNTHESIS OF CERAMIC PLATES, A NOVEL ROUTE TO PRODUCE HYBRID NANOPARTICLES WITH MULTIMODAL PROPERTIES
published pages: , ISSN: , DOI:
2nd Erwin Schrödinger Symposium 2016 of the Erwin Schrödinger Society for Nanosciences: Abstract Book 2019-06-13
2017 Niusha Lasemi, Ulrich Pacher, Christian Rentenberger, Oscar Bomatí-Miguel, Wolfgang Kautek
Laser-Assisted Synthesis of Colloidal Ni/NiO x Core/Shell Nanoparticles in Water and Alcoholic Solvents
published pages: 1118-1124, ISSN: 1439-4235, DOI: 10.1002/cphc.201601181
ChemPhysChem 18/9 2019-06-13
2016 N. Lasemi, O. Bomati-Miguel, U. Pacher, R. Lahoz, C. Rentenberger, K. Richter, W. Kautek
Core-Shell Tungsten-Iron Nanoparticles by Laser-Assisted Synthesis in Liquid Contact
published pages: 120, ISSN: , DOI:
4TH CONFERENCE ON ADVANCED NANOPARTICLE GENERATION AND EXCITATION BY LASERS IN LIQUIDS (ANGEL): ABSTRACT BOOK 2019-06-13
2016 R. Lahoz, N. Lasemi, C. Rentenberger, G. Reisinger, K. Richter, W. Kautek, O. Bomati-Miguel.b,e*
LASER ABLATION IN LIQUIDS SYNTHESIS OF BIOCOMPATIBLE NANOPARTICLES FOR MEDICAL IMAGIN APPLICATIONS
published pages: , ISSN: , DOI:
2nd Erwin Schrödinger Symposium 2016 of the Erwin Schrödinger Society for Nanosciences. Abstract Book 2019-06-13
2017 Niusha Lasemi, Aida Naghilou, Oskar Armbruster, Ulrich Pacher, Ana Subotic, Markus Kitzler, Oscar Bomati-Miguel, Leonid V. Zhigilei, Wolfgang Kautek
Laser Ablation of Metals in Liquid Contact
published pages: OP-26, ISSN: , DOI:
Proceedings of the 17. ÖSTERREICHISCHE CHEMIETAGE th 17 Austrian Chemistry Days Joint Meeting of the Swiss & Austrian Chemical Societies Bianual 2019-06-13
2016 O. Bomati-Miguel, R. Lahoz, C. Rentenberger, W. Kautek
Direct Fabrication of Colloidal Amorphous Zero Valent Iron (nZVI) Nanoparticles by Liquid-Assisted Pulsed Laser Ablation
published pages: , ISSN: , DOI:
2017 E-MRS Spring: Abstract Book 2019-06-13
2018 N. Lasemi, U. Pacher, L.V. Zhigilei, O. Bomatí-Miguel, R. Lahoz, W. Kautek
Pulsed laser ablation and incubation of nickel, iron and tungsten in liquids and air
published pages: 772-779, ISSN: 0169-4332, DOI: 10.1016/j.apsusc.2017.10.082
Applied Surface Science 433 2019-06-13
2016 N. Lasemi, O. Bomati-Miguel, U. Pacher, R. Lahoz, C. Rentenberger, K. Richter, W. Kautek
Laser synthesis of colloidal nanoparticles in various fluids
published pages: , ISSN: , DOI:
E-MRS 2016 SPRING MEETING ABSTRACT BOOK 2019-06-13

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