Opendata, web and dolomites


Molecular Understanding of Generation and Trafficking of Mitochondrial [4Fe-4S] Clusters

Total Cost €


EC-Contrib. €






 FourFeFourS project word cloud

Explore the words cloud of the FourFeFourS project. It provides you a very rough idea of what is the project "FourFeFourS" about.

career    2s    outside    dictates    conjunction    cluster    maintenance    combine    mitochondrial    maturation    4fe    reconstitution    manner    vital    expand    group    least    stability    utilizing    qua    human    science    basic    sine    responsible    fatal    proteins    4s    integrity    17    play    dna    fe    biology    incorporating    isc    protein    metal    solid    light    ions    inorganic    dysfunction    relevance    unified    assembly    disease    cutting    2fe    depends    elucidate    fourfefours    biogenesis    discover    active    machinery    foundation    edge    spectrometric    spectroscopic    iron    world    chemicals    biochemistry    leader    sulfur    genomic    underlying    mitochondria    expertise    assay    multidisciplinary    clusters    cytosolic    fine    biological    shed    isolated    sense    elucidation    concentrations    structure    diseases    expert    energy    cellular    ongoing    efforts    broadest    molecular    roles    mechanisms    union    functions    tutelage    biotechnological    intends    poorly    nuclear    function    utmost    entails    experiments    transfer    microorganisms    biochemical   

Project "FourFeFourS" data sheet

The following table provides information about the project.


Organization address
postcode: 35037

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-15   to  2017-06-14


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Iron-sulfur [Fe-S] clusters play a vital role in numerous cellular functions. They are a sine qua non for cellular energy production and maintenance of genomic stability. Therefore, elucidation of the biogenesis of [2Fe-2S] and [4Fe-4S] proteins is of utmost importance for basic science in its broadest sense, as it is for ongoing efforts to establish their relevance to human disease and their utilization for biotechnological production of fine chemicals in microorganisms. The iron-sulfur cluster (ISC) assembly process is responsible for incorporating the inorganic cluster into [Fe-S]-associated proteins in the mitochondria. Cytosolic and nuclear [Fe-S] protein assembly that dictates cellular iron concentrations and DNA integrity outside of the mitochondria also depends on the function of the ISC machinery. The mitochondrial ISC biogenesis machinery entails at least 17 proteins, yet how the proteins for [4Fe-4S] maturation work in a unified manner to produce the active cluster and transfer it to target proteins remains poorly understood. FourFeFourS intends to discover the underlying mechanisms of [4Fe-4S] biogenesis in the mitochondria, which could shed new light into how dysfunction of the proteins involved may lead to fatal diseases. To this end, studies will combine a biochemical reconstitution assay of the biological process utilizing isolated ISC proteins in conjunction with spectroscopic and spectrometric experiments that elucidate detailed protein function and molecular structure. In carrying out this cutting-edge research under the tutelage of a world-leading expert on iron-sulfur protein biogenesis, I will expand my expertise within the multidisciplinary field of biochemistry – in particular my understanding of the roles of metal ions in biology. In the process, I will build a solid foundation for a future research career as a group leader within the European Union.


year authors and title journal last update
List of publications.
2017 Joseph J. Braymer, Roland Lill
Iron–sulfur cluster biogenesis and trafficking in mitochondria
published pages: 12754-12763, ISSN: 0021-9258, DOI: 10.1074/jbc.R117.787101
Journal of Biological Chemistry 292/31 2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FOURFEFOURS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FOURFEFOURS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More  

STRESS-Mums (2019)

Study on TRansition and Exclusion in Society of Single-Mums

Read More