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Experimental Microbiome

“How mutualism evolves: Experimental microbiome evolution in gnotobiotic flies”

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Experimental Microbiome" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://igfl.ens-lyon.fr/equipes/f.-leulier-functional-genomics-of-host-intestinal-bacteria-interactions/database-for-comparative-genomics-of-54-l-plantarum-strains
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

All metazoans harbour considerable numbers of commensal microorganisms in the gut, named microbiota, that contribute to many aspects of normal host physiology. Scientific research has provided invaluable contributions to our understanding of the relationship between host and its microbiota; however, the molecular mechanisms through which the microbiota exerts its beneficial influence are still largely undefined. The meta’omics revolution is promoting an explosion of interest in how the gut bacterial community impacts physiology and propensity to disease. In addition, gnotobiotic model organisms provide unique opportunities to study host-microbiota interplay with a level of experimental control that is not achievable in human studies. The coupling of those two approaches should allow to pinpoint key mechanisms underlying this mutually beneficial relationship. This research proposal aims to use those approaches to understand the bacterial genetic pathways mediating host benefits. To this end, we will apply in vivo experimental evolution to mutualistic bacteria, using gnotobiotic animal models. The work will investigate the association between the host model Drosophila melanogaster and one of its most abundant commensal bacteria, Lactobacillus plantarum, which was demonstrated to be beneficial to its host physiology by promoting juvenile growth and maturation.

 Publications

year authors and title journal last update
List of publications.
2015 Maria Elena Martino, Jumamurat R. Bayjanov, Pauline Joncour, Sandrine Hughes, Benjamin Gillet, Michiel Kleerebezem, Roland Siezen, Sacha A. F. T. van Hijum, François Leulier
Resequencing of the Lactobacillus plantarum Strain WJL Genome
published pages: e01382-15, ISSN: 2169-8287, DOI: 10.1128/genomeA.01382-15
Genome Announcements 3/6 2019-07-24
2016 Maria Elena Martino, Jumamurat R. Bayjanov, Brian E. Caffrey, Michiel Wels, Pauline Joncour, Sandrine Hughes, Benjamin Gillet, Michiel Kleerebezem, Sacha A.F.T. van Hijum, François Leulier
Nomadic lifestyle of Lactobacillus plantarum revealed by comparative genomics of 54 strains isolated from different habitats
published pages: 4974-4989, ISSN: 1462-2912, DOI: 10.1111/1462-2920.13455
Environmental Microbiology 18/12 2019-07-24
2015 Maria Elena Martino, Jumamurat R. Bayjanov, Pauline Joncour, Sandrine Hughes, Benjamin Gillet, Michiel Kleerebezem, Roland Siezen, Sacha A. F. T. van Hijum, François Leulier
Nearly Complete Genome Sequence of Lactobacillus plantarum Strain NIZO2877
published pages: e01370-15, ISSN: 2169-8287, DOI: 10.1128/genomeA.01370-15
Genome Announcements 3/6 2019-07-24
2016 M. Schwarzer, K. Makki, G. Storelli, I. Machuca-Gayet, D. Srutkova, P. Hermanova, M. E. Martino, S. Balmand, T. Hudcovic, A. Heddi, J. Rieusset, H. Kozakova, H. Vidal, F. Leulier
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition
published pages: 854-857, ISSN: 0036-8075, DOI: 10.1126/science.aad8588
Science 351/6275 2019-07-24

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