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PlastiCell SIGNED

Using a natural cellular plasticity event to decypher the cellular requirements and molecular circuitry promoting transdifferentiation at the single cell level.

Total Cost €

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EC-Contrib. €

0

Partnership

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 PlastiCell project word cloud

Explore the words cloud of the PlastiCell project. It provides you a very rough idea of what is the project "PlastiCell" about.

td    medicine    circuitry    model    questions    conversion    underlie    permissive    systematically    frontiers    relative    rectal    fascinating    regenerative    occur    differentiated    provides    tackles    impressive    events    developmental    identities    event    experimentally    species    cellular    motoneuron    elucidate    cancerous    100    interconversions    unambiguous    revealed    efficient    phyla    discrete    aka    reprogramming    reported    naturally    molecular    counteracted    identity    diverse    apparently    plasticity    mice    push    demonstrated    brake    influence    network    first    conserved    asset    identical    predictable    natural    tremendous    how    followed    neighbours    transdifferentiation    demonstration    cells    unravel    reprogrammed    initiation    architecture    single    raises    efficiency    vivo    protect    cell    networks    somatic    mechanisms    nuclear    question    complexes    act    functionally    ease    perception    context    avenues    jellyfish    reprograming    acquire    elegans    types   

Project "PlastiCell" data sheet

The following table provides information about the project.

Coordinator
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE 

Organization address
address: Rue Laurent Fries 1
city: ILLKIRCH GRAFFENSTADEN
postcode: 67404
website: www.igbmc.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.igbmc.fr/research/department/1/team/8/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) coordinator 2˙000˙000.00

Map

 Project objective

How differentiated cells can change their identity is a fascinating question. Indeed, natural interconversions between functionally distinct somatic cell types (aka transdifferentiation, Td) have been reported in species as diverse as jellyfish and mice, while experimentally induced reprogramming of differentiated cells has been demonstrated. The relative ease with which cellular identities can be reprogrammed raises a number of exciting questions: What mechanisms and steps allow a given cell, but not its apparently identical neighbours, to naturally acquire a new plasticity potential and change its identity? How does the cellular context influence the ability of a cell to be reprogrammed? What cellular mechanisms must be counteracted to allow natural reprograming to occur? What circuitry underlie the impressive efficiency observed in natural events? The proposed project tackles these questions To systematically identify the molecular networks and cellular requirements of Td, we established a simple model of natural Td, in C. elegans, where the conversion of a rectal cell into a motoneuron is followed in vivo. This model is unique: it is 100% efficient, predictable and provides the first unambiguous demonstration, at the single cell level, of natural Td. The study of such natural event has revealed a key asset to unravel the discrete steps of the process, their control and the conserved cell plasticity factors promoting its initiation, while leading to important concepts conserved across phyla. We propose here 4 aims to push new frontiers and: i) Define what makes a cellular context permissive; ii) Elucidate the conserved nuclear complexes and network architecture promoting efficient reprogramming; iii) Identify mechanisms that protect the differentiated identity and act as a brake to Td. Understanding cell plasticity in vivo will have a tremendous impact on our perception of developmental and cancerous processes and could open new avenues for regenerative medicine.

 Publications

year authors and title journal last update
List of publications.
2016 M. Doitsidou, S. Jarriault, R. J. Poole
Next-Generation Sequencing-Based Approaches for Mutation Mapping and Identification in Caenorhabditis elegans
published pages: 451-474, ISSN: 0016-6731, DOI: 10.1534/genetics.115.186197
Genetics 204/2 2019-11-14
2017 Magdalena Götz, Sophie Jarriault
Programming and reprogramming the brain: a meeting of minds in neural fate
published pages: 2714-2718, ISSN: 0950-1991, DOI: 10.1242/dev.150466
Development 144/15 2019-11-14
2016 Sarah F. Becker, Sophie Jarriault
Natural and induced direct reprogramming: mechanisms, concepts and general principles — from the worm to vertebrates
published pages: 154-163, ISSN: 0959-437X, DOI: 10.1016/j.gde.2016.06.014
Current Opinion in Genetics and Development 40 2019-11-14
2018 Laura Vibert, Anne Daulny, Sophie Jarriault
Wound healing, cellular regeneration and plasticity: the elegans way
published pages: 491-505, ISSN: 0214-6282, DOI: 10.1387/ijdb.180123sj
The International Journal of Developmental Biology 62/6-7-8 2019-11-14

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