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Sulphirulence

Re-engineering of fungal sulphur metabolism to limit mould viability and virulence.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Sulphirulence project word cloud

Explore the words cloud of the Sulphirulence project. It provides you a very rough idea of what is the project "Sulphirulence" about.

gaseous    candidate    world    precursor    proteins    source    function    virulence    eliminated    deficient    responsible    sulphur    fungal    discovered    mammalian    occurrence    eukaryotic    genome    seek    experimental    human    mutational    mould    h2s    appears    clinical    intact    aspergillus    infection    designing    mutants    antifungal    therapies    regulation    harness    wish    sole    gt    million    annum    pathogen    correlates    exploited    cells    mice    inorganic    scientific    fungus    signalling    molecular    fumigatus    cysteine    expertise    essentiality    respectively    view    biosynthesis    class    vivo    synthesis    transgenic    blockade    transcriptome    oxidized    enzyme    precise    viability    leaving    homocysteine    host    requirement    sulfhydration    sequences    enforce    exploitable    disease    decipher    foremost    methionine    lungs    scrutinizing    illnesses    containing    pathogenicity    secondary    assimilation    synthase    snps    sources    molecule   

Project "Sulphirulence" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 183˙454.00

Map

 Project objective

Aspergillus fumigatus, the major mould pathogen of human lungs, is responsible for > 2 million illnesses per annum in Europe . I have discovered that sulphur is an essential host-derived element during A. fumigatus infection . This finding is novel, and highly exploitable as a) Synthesis of the sulphur-containing molecule methionine appears to be essential for viability of A. fumigatus b) Regulation of sulphur assimilation is essential for A. fumigatus virulence and c) The foremost candidate sulphur source in mammalian lungs (H2S) is gaseous, and recently identified as a novel signalling molecule in eukaryotic cells . I now wish to harness world-class clinical and scientific expertise in the field of fungal pathogenicity to identify the precise molecular source of sulphur exploited by A. fumigatus during experimental and clinical infection, with a view to designing novel antifungal therapies. OBJECTIVES 1. To define the role of methionine synthase in A. fumigatus viability I will enforce a mutational blockade upon biosynthesis of the sole methionine precursor, homocysteine, while leaving methionine synthase intact. This will decipher between essentiality of methionine biosynthesis, and essentiality of a secondary function of the methionine synthase enzyme. 2. I have eliminated cysteine and oxidized inorganic-S sources as in-host sources of sulphur. I will now address, via mutational analysis in the fungus, in-host transcriptome and transgenic mice whether methionine or H2S are exploited in the host. Having defined the S-source exploited in vivo, I will seek correlates with human disease by scrutinizing human and fungal genome sequences for SNPs associated, respectively, with human H2S production and fungal sulphur assimilation. 3. I will use A. fumigatus mutants deficient in production and assimilation of H2S to address the occurrence of, and requirement for, sulfhydration of fungal proteins during mammalian infection.

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The information about "SULPHIRULENCE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2024-03-19 6:53:33) correctly updated