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BIOSTASIS SIGNED

BIOlogical SignaTures of AnhydrobioSIS via comparative transcriptomics on different evolutionary lineages within tardigrades

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BIOSTASIS project word cloud

Explore the words cloud of the BIOSTASIS project. It provides you a very rough idea of what is the project "BIOSTASIS" about.

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Project "BIOSTASIS" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

The current proposal revolves around the dehydration induced state, anhydrobiosis - a survival strategy found among a range of life-forms in face of severe desiccation. Anhydrobiosis is defined by a reversible shut-down of metabolism (biostasis) and it seems to involve adaptations at all levels of organismic organization. The current proposal uses tardigrades as a model to gain novel insight into molecular signatures underlying this unique biological phenomenon. Several molecules have been implicated in the anhydrobiotic mechanism; however, so far studies have been returning contradictory results with respect to the differential expression of genes in pre- and post-anhydrobiotic phases. Interestingly, our preliminary, unpublished data from Møbjerg lab suggest that there could be lineage specific strategies to anhydrobiosis. Consequently, I will use transcriptome sequencing (RNAseq) and ddPCR to reveal key-player genes and characterize functional pathways involved in i) different stages of anhydrobiosis of single tardigrade species and ii) between different evolutionary lineages within the phylum. The mentioned methods constitute the most important training element of my project. The overall goal of the proposal is to determine potential gene expression signatures for anhydrobiosis establishing a transcription profile that is i) characteristic of a particular physiological state and ii) that could possibly reflect the phylogenetic position of a taxon. My previous extensive experience on phylogenetic and molecular dating methods will, in this respect, be utilized to estimate the chronology of the possible diversification of anhydrobiosis within evolutionary lineages. My research will be conducted at the Møbjerg lab, which represents one of the world’s leading groups in the field of tardigrade biology. The group is situated at the Department of Biology, University Copenhagen, which is a superbly equipped institution with a high international profile.

 Publications

year authors and title journal last update
List of publications.
2019 Maria Kamilari, Aslak Jørgensen, Morten Schiøtt, Nadja Møbjerg
Comparative transcriptomics suggest unique molecular adaptations within tardigrade lineages
published pages: 607, ISSN: 1471-2164, DOI: 10.1186/s12864-019-5912-x
BMC Genomics 20/1 2020-03-23

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