Explore the words cloud of the BioBarPro project. It provides you a very rough idea of what is the project "BioBarPro" about.
The following table provides information about the project.
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
|Coordinator Country||Switzerland [CH]|
|Total cost||150˙000 €|
|EC max contribution||150˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-12-01 to 2017-05-31|
Take a look of project's partnership.
|1||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||coordinator||150˙000.00|
Colorectal cancer (CRC) is caused by alterations in genes that regulate tissue growth and the risk of developing CRC is influenced by a combination of environmental and genetic factors. Although CRC is often preventable by removing precursor lesions, screening efforts have been hampered by low participation rates and by performance limitations of the screening tools themselves. Detection of blood in faeces is currently the most common screening tool, while stool DNA testing of molecular markers has emerged as a biologically rational and user-friendly strategy for the non-invasive detection of CRC and critical precursor lesions. This advance has significantly increased performance in detecting CRC, but still more than half of the precancerous lesions cannot be detected. The stool DNA test performance for detecting precancerous lesions is expected to be improved substantively by including a completely new type of biomarker, those formed earlier than genetic mutations in the process of carcinogenesis. Such biomarkers are DNA adducts; DNA molecules bound to chemicals. If not repaired, these DNA adducts generate mutations. Herein, we propose to expand an ERC-funded research result into a kit for measuring CRC-initiating DNA adducts in a stool sample. This kit will enable personalized feedback that quantitatively integrates environmental and genetic factors in colon-cancer associated DNA damage. We have filed a patent application for the chemical basis of the technology and have partnered with an ETH spin-off for the scientific development of our existing proof of principle assay to a prototype kit. In parallel to the scientific work, during the Proof of Concept phase, we will address a phase of the overall commercialization plan that involves licensing the technology to a business partner in the life sciences sector.
|year||authors and title||journal||last update|
Thomas Hartung, Rex E. FitzGerald, Paul Jennings, Gary R. Mirams, Manuel C. Peitsch, Amin Rostami-Hodjegan, Imran Shah, Martin F. Wilks, Shana J. Sturla
Systems Toxicology: Real World Applications and Opportunities
published pages: 870-882, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.7b00003
|Chemical Research in Toxicology 30/4||2019-07-25|
Alessia Stornetta, Maike Zimmermann, George D. Cimino, Paul T. Henderson, Shana J. Sturla
DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
published pages: 388-409, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.6b00380
|Chemical Research in Toxicology 30/1||2019-07-25|
Ioannis A. Trantakis, Arman Nilforoushan, Heidi A. Dahlmann, Celine K. StÃ¤uble, Shana J. Sturla
In-Gene Quantification of O 6 -Methylguanine with Elongated Nucleoside Analogues on Gold Nanoprobes
published pages: 8497-8504, ISSN: 0002-7863, DOI: 10.1021/jacs.6b03599
|Journal of the American Chemical Society 138/27||2019-07-25|
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