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BioBarPro

A Hot-Spot Bio-Barcode Strategy for Prognostic Biomarkers In Colorectal Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BioBarPro" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 150˙000.00

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 Project objective

Colorectal cancer (CRC) is caused by alterations in genes that regulate tissue growth and the risk of developing CRC is influenced by a combination of environmental and genetic factors. Although CRC is often preventable by removing precursor lesions, screening efforts have been hampered by low participation rates and by performance limitations of the screening tools themselves. Detection of blood in faeces is currently the most common screening tool, while stool DNA testing of molecular markers has emerged as a biologically rational and user-friendly strategy for the non-invasive detection of CRC and critical precursor lesions. This advance has significantly increased performance in detecting CRC, but still more than half of the precancerous lesions cannot be detected. The stool DNA test performance for detecting precancerous lesions is expected to be improved substantively by including a completely new type of biomarker, those formed earlier than genetic mutations in the process of carcinogenesis. Such biomarkers are DNA adducts; DNA molecules bound to chemicals. If not repaired, these DNA adducts generate mutations. Herein, we propose to expand an ERC-funded research result into a kit for measuring CRC-initiating DNA adducts in a stool sample. This kit will enable personalized feedback that quantitatively integrates environmental and genetic factors in colon-cancer associated DNA damage. We have filed a patent application for the chemical basis of the technology and have partnered with an ETH spin-off for the scientific development of our existing proof of principle assay to a prototype kit. In parallel to the scientific work, during the Proof of Concept phase, we will address a phase of the overall commercialization plan that involves licensing the technology to a business partner in the life sciences sector.

 Publications

year authors and title journal last update
List of publications.
2017 Thomas Hartung, Rex E. FitzGerald, Paul Jennings, Gary R. Mirams, Manuel C. Peitsch, Amin Rostami-Hodjegan, Imran Shah, Martin F. Wilks, Shana J. Sturla
Systems Toxicology: Real World Applications and Opportunities
published pages: 870-882, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.7b00003
Chemical Research in Toxicology 30/4 2019-07-25
2017 Alessia Stornetta, Maike Zimmermann, George D. Cimino, Paul T. Henderson, Shana J. Sturla
DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine
published pages: 388-409, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.6b00380
Chemical Research in Toxicology 30/1 2019-07-25
2016 Ioannis A. Trantakis, Arman Nilforoushan, Heidi A. Dahlmann, Celine K. Stäuble, Shana J. Sturla
In-Gene Quantification of O 6 -Methylguanine with Elongated Nucleoside Analogues on Gold Nanoprobes
published pages: 8497-8504, ISSN: 0002-7863, DOI: 10.1021/jacs.6b03599
Journal of the American Chemical Society 138/27 2019-07-25

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The information about "BIOBARPRO" are provided by the European Opendata Portal: CORDIS opendata.

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