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Three dimensional breast cancer models for X-ray Imaging research

Total Cost €


EC-Contrib. €






Project "MaXIMA" data sheet

The following table provides information about the project.


Organization address
address: Studentska 1
city: VARNA
postcode: 9010

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Bulgaria [BG]
 Project website
 Total cost 998˙050 €
 EC max contribution 998˙050 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-TWINN-2015
 Funding Scheme CSA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNICAL UNIVERSITY OF VARNA BG (VARNA) coordinator 511˙150.00


 Project objective

Nowadays, the development of realistic three-dimensional computational and physical models of breast tumours with irregular shapes is an urgent requirement. The availability of such models is a powerful instrument in the hands of engineers, physicians and physicists to be used in the development of new technologies for precise definition of the boundaries of these cancers. Scientists from the biomedical engineering unit at Technical University of Varna are present in this area both at modelling and simulation of computational breast phantoms and x-ray breast imaging techniques. To advance in their research aims and therefore to raise the profile of their researchers and S&T capacity of the host organisation, collaborations with top research institutions from complementary areas of expertise are a requirement. In addition, the touch with world experts in this area is needed in order to have local researchers at host informed about the most current findings in the field and to discuss specific scientific issues that otherwise will not have such a chance.

The main objective of this action is to increase the research and innovation capacity of the host organisation in the field of computational modelling of breast tumours (including cancers with irregular shape) and their use in studies of advanced x-ray breast imaging techniques such as breast tomosynthesis and phase contrast imaging. For this purpose, the project will establish a close and sustainable collaboration platform, in the form of a network of three scientific groups working in the specific domain of modelling and simulations dedicated for studies of x-ray breast imaging techniques. The network will aim to (a) increase the research and innovation capacity of the host organisation, (b) integrate results of ongoing research, (c) facilitate progress beyond the actual individual possibilities, (d) advance the research activities of all partners through a joint and mutually fruitful collaboration.


List of deliverables.
Report of previous publications in the participant portal Documents, reports 2019-07-26 15:54:36
Launch of MaXIMA project website Websites, patent fillings, videos etc. 2019-07-26 15:54:36
Launch of MaXIMA project Other 2019-07-26 15:54:36
Systemised and consolidated educational materials Websites, patent fillings, videos etc. 2019-07-26 15:54:36
Report on dissemination and communication activities Documents, reports 2019-07-26 15:54:36

Take a look to the deliverables list in detail:  detailed list of MaXIMA deliverables.


year authors and title journal last update
List of publications.
2018 Antonio Sarno, Giovanni Mettivier, Raffaele M. Tucciariello, Kristina Bliznakova, John M. Boone, Ioannis Sechopoulos, Francesca Di Lillo, Paolo Russo
Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models
published pages: 99-107, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2018.05.021
Physica Medica 51 2019-07-26
2018 Tri Wigati, Kristina; Manssens, Hannah; Vancoillie, Liesbeth; Cockmartin, Lesley; Soejoko, Djarwani S.; Bosmans, Hilde; Bliznakova, Kristina
Virtual study to investigate the detectability of breast abnormalities on 2D mammography and digital breast tomosynthesis
published pages: 124-138, ISSN: 2355-2719, DOI: 10.5281/zenodo.1220580
Journal of Medical Physics and Biophysics Vol 5, No 1 2019-07-26
2016 Giovanni Mettivier, Kristina Bliznakova, Francesca Di Lillo, Antonio Sarno, Paolo Russo
Evaluation of the BreastSimulator Software Platform for Breast Tomography: Preliminary Results
published pages: 145-151, ISSN: , DOI: 10.1007/978-3-319-41546-8_19
Lecture Notes in Copmuter Science 2019-07-26
2017 Yanka Baneva, Kristina Bliznakova, Lesley Cockmartin, Stoyko Marinov, Ivan Buliev, Giovanni Mettivier, Hilde Bosmans, Paolo Russo, Nicholas Marshall, Zhivko Bliznakov
Evaluation of a breast software model for 2D and 3D X-ray imaging studies of the breast
published pages: 78-86, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2017.04.024
Physica Medica 41 2019-07-26
2017 Antonio Sarno, David R. Dance, Ruben E. van Engen, Kenneth C. Young, Paolo Russo, Francesca Di Lillo, Giovanni Mettivier, Kristina Bliznakova, Baowei Fei, Ioannis Sechopoulos
A Monte Carlo model for mean glandular dose evaluation in spot compression mammography
published pages: 3848-3860, ISSN: 0094-2405, DOI: 10.1002/mp.12339
Medical Physics 44/7 2019-07-26
2018 Kristina Bliznakova
Three dimensional breast cancer models for x-ray imaging research
published pages: 154 - 160, ISSN: , DOI: 10.5281/zenodo.1407919
Proceedings of the 1st International Conference Applied Computer Technologies: ACT 2018, June, 21-23 Ohrid, FYROM 2019-07-26
2016 Nikolay Dukov, Firgan Feradov, Kristina Bliznakova, Elica Encheva, Yana Gluhcheva, Daniel Bulyashki, Radoslav Radev
Computational Breast Cancer Models Created from Patient Specific CT Images: Preliminary Results
published pages: 106 - 109, ISSN: , DOI: 10.5281/zenodo.1065918
Scientific Works of the Union of Scientists in Bulgaria Series G. Medicine, Pharmacy an 2019-07-26
2016 Danail Ivanov, Silviya Boncheva, Kristina Bliznakova
Feasibility Study of the Suitability of Several Low Density Materials for the Production of X-Ray Physical Breast Phantoms
published pages: 119 - 122, ISSN: , DOI: 10.5281/zenodo.1065989
Scientific Works of the Union of Scientists in Bulgaria Series G. Medicine, Pharmacy an 2019-07-26
2016 Stoyko Marinov, Ivan Buliev, Zhivko Bliznakov
Software Platform for Evaluation of X-ray Images: Application for Validation of Anthropomorphic Software Breast Model
published pages: 139 - 142, ISSN: , DOI: 10.5281/zenodo.1066007
Scientific Works of the Union of Scientists in Bulgaria Series G. Medicine, Pharmacy an 2019-07-26
2016 Kristina Bliznakova, Giovanni Mettivier, Paolo Russo, Ivan Buliev
Contrast Detail Phantoms for X-ray Phase-Contrast Mammography and Tomography
published pages: 611-617, ISSN: , DOI: 10.1007/978-3-319-41546-8_76
Lecture Notes in Computer Science 2019-07-26
2016 K Bliznakova, P Russo, Z Kamarianakis, G Mettivier, H Requardt, A Bravin, I Buliev
In-line phase-contrast breast tomosynthesis: a phantom feasibility study at a synchrotron radiation facility
published pages: 6243-6263, ISSN: 0031-9155, DOI: 10.1088/0031-9155/61/16/6243
Physics in Medicine and Biology 61/16 2019-07-26
2018 J Vignero, N W Marshall, K Bliznakova, H Bosmans
A hybrid simulation framework for computer simulation and modelling studies of grating-based x-ray phase-contrast images
published pages: 14NT03, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aaceb8
Physics in Medicine & Biology 63/14 2019-07-26
2018 A. Sarno, G. Mettivier, F. Di Lillo, K. Bliznakova, I. Sechopoulos, P. Russo
Homogeneous vs. patient specific breast models for Monte Carlo evaluation of mean glandular dose in mammography
published pages: 56-63, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2018.04.392
Physica Medica 51 2019-07-26
2016 Zhivko Bliznakov, Yanita Chernogorova, Kristina Bliznakova
Three Dimensional Breast Cancer Models for X-Ray Imaging Research
published pages: 98 - 101, ISSN: , DOI: 10.5281/zenodo.1065850
Scientific Works of the Union of Scientists in Bulgaria Series G. Medicine, Pharmacy an 2019-07-26
2017 G Mettivier, K Bliznakova, I Sechopoulos, J M Boone, F Di Lillo, A Sarno, R Castriconi, P Russo
Evaluation of the BreastSimulator software platform for breast tomography
published pages: 6446-6466, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aa6ca3
Physics in Medicine & Biology 62/16 2019-07-26
2016 Kristina Bliznakova, Zacharias Kamarianakis, Ivan Buliev
Computer-Based Platform for Phase Contrast Tomosynthesis: Targeting an Application for Breast Imaging
published pages: 367-371, ISSN: , DOI: 10.1007/978-3-319-32703-7_72
XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016 2019-07-26
2017 Yanita Chernogorova
Business Sustainability Plan for Innovative Products
published pages: , ISSN: , DOI: 10.5281/zenodo.1068233
\"Proceedings of the 3rd Scientific Forum \"\"Innovation and Business\"\" 2017\" 2019-07-26
2018 Danail Ivanov, Kristina Bliznakova, Ivan Buliev, Peycho Popov, Giovanni Mettivier, Paolo Russo, Francesca Di Lillo, Antonio Sarno, Janne Vignero, Hilde Bosmans, Alberto Bravin, Zhivko Bliznakov
Suitability of low density materials for 3D printing of physical breast phantoms
published pages: 175020, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aad315
Physics in Medicine & Biology 63/17 2019-07-26
2018 Galya Gospodinova, Kristina Bliznakova
An Approach of Modelling of Breast Lesions
published pages: 149 - 153, ISSN: , DOI: 10.5281/zenodo.1407925
Proceedings of the 1st International Conference Applied Computer Technologies: ACT 2018, June, 21-23 Ohrid, FYROM 2019-07-26
2019 Giuseppina Esposito, Giovanni Mettivier, Kristina Bliznakova, Zhivko Bliznakov, Hilde Bosmans, Alberto Bravin, Ivan Buliev, Francesca Di Lillo, Danail Ivanov, Martina Minutillo, Antonio Sarno, Janne Vignero, Paolo Russo
Investigation of the refractive index decrement of 3D printing materials for manufacturing breast phantoms for phase contrast imaging
published pages: , ISSN: 0031-9155, DOI: 10.1088/1361-6560/ab0670
Physics in Medicine and Biology 2019-07-26
2018 T.D. Dikova, D.A. Dzhendov, D. Ivanov, K. Bliznakova
Dimensional accuracy and surfaceroughness of polymeric dental bridgesproduced by different 3D printingprocesses
published pages: 65-75, ISSN: 1897-2764, DOI: 10.5604/01.3001.0012.8660
Archives of Materials Science and Engineering 2/94 2019-07-26
2018 A. Sarno, G. Mettivier, F. Di Lillo, R.M. Tucciariello, K. Bliznakova, P. Russo
Normalized glandular dose coefficients in mammography, digital breast tomosynthesis and dedicated breast CT
published pages: 142-148, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2018.09.002
Physica Medica 55 2019-07-26
2019 Nikolay Dukov, Kristina Bliznakova, Firgan Feradov, Ivan Buliev, Hilde Bosmans, Giovanni Mettivier, Paolo Russo, Lesley Cockmartin, Zhivko Bliznakov
Models of breast lesions based on three-dimensional X-ray breast images
published pages: 80-87, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2018.12.012
Physica Medica 57 2019-07-26
2018 Janne Vignero, Nicholas W. Marshall, Greetje Vande Velde, Kristina Bliznakova, Hilde Bosmans
Translation from murine to human lung imaging using x-ray dark field radiography: A simulation study
published pages: e0206302, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0206302
PLOS ONE 13/10 2019-07-26

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