Explore the words cloud of the TranslationRegCode project. It provides you a very rough idea of what is the project "TranslationRegCode" about.
The following table provides information about the project.
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
|Coordinator Country||Israel [IL]|
|Total cost||1˙587˙500 €|
|EC max contribution||1˙587˙500 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-03-01 to 2022-02-28|
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|1||TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY||IL (HAIFA)||coordinator||1˙587˙500.00|
Organisms across all kingdoms share several systems that are essential to life, one of the most central being protein synthesis. Living in a continuously changing environment, cells need to constantly respond to various environmental cues and change their protein landscape. In extreme cases, cells globally shut down protein synthesis and upregulate stress-protective proteins. Mechanisms of translational repression or selective enhancement of stress-induced proteins have been characterized, but their effects were demonstrated on an individual mRNA basis. Which target mRNAs are translationally regulated in response to different environmental cues, and what are the cis-regulatory elements involved, largely remain as open questions. Using ribosome footprint profiling, I recently discovered a novel mode of translational control in stress, underscoring the potential of new technologies to uncover novel regulatory mechanisms. But while transcription cis-regulatory elements have been thoroughly mapped in the past decade, and splicing regulatory elements are accumulating, the identification of translation cis-regulatory elements is lagging behind. Here I propose to crack the mammalian translation regulatory code, and close this long-standing gap. I present a novel interdisciplinary framework to comprehensively identify translation cis-regulatory elements, and map their mRNAs targets in a variety of cellular perturbations. Importantly, we plan to explore mechanisms underlying novel cis-regulatory elements, and create the first genome-wide functionally annotated translation regulatory code. The translation regulatory code will map targets of existing mechanisms and shed light on newly identified pathways that play a role in stress-induced translational control. The proposed project is an imperative stepping stone to understanding translational regulation by cis-regulatory elements, opening new avenues in the functional genomics research of translational control.
|year||authors and title||journal||last update|
Nir Gonen, Anatoly Meller, Niv Sabath, Reut Shalgi
Amino Acid Biosynthesis Regulation during Endoplasmic Reticulum Stress Is Coupled to Protein Expression Demands
published pages: 204-213, ISSN: 2589-0042, DOI: 10.1016/j.isci.2019.07.022
Nir Gonen, Niv Sabath, Christopher B. Burge, Reut Shalgi
Widespread PERK-dependent repression of ER targets in response to ER stress
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-38705-5
|Scientific Reports 9/1||2019-11-15|
Niv Sabath, Anna Vilborg, Joan A. Steitz, Reut Shalgi
Caution needs to be taken when assigning transcription start sites to ends of protein-coding genes: a rebuttal
published pages: , ISSN: 1479-7364, DOI: 10.1186/s40246-018-0164-4
|Human Genomics 12/1||2019-11-15|
Yuval Wiesel, Niv Sabath, Reut Shalgi
DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4983-4
|BMC Genomics 19/1||2019-11-15|
Anna Vilborg, Niv Sabath, Yuval Wiesel, Jenny Nathans, Flonia Levy-Adam, Therese A. Yario, Joan A. Steitz, Reut Shalgi
Comparative analysis reveals genomic features of stress-induced transcriptional readthrough
published pages: E8362-E8371, ISSN: 0027-8424, DOI: 10.1073/pnas.1711120114
|Proceedings of the National Academy of Sciences 114/40||2019-11-15|
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