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TranslationRegCode SIGNED

Cracking the Translation Regulatory Code

Total Cost €


EC-Contrib. €






 TranslationRegCode project word cloud

Explore the words cloud of the TranslationRegCode project. It provides you a very rough idea of what is the project "TranslationRegCode" about.

plan    decade    ribosome    stepping    first    newly    cellular    explore    underscoring    functional    constantly    protective    proteins    individual    demonstrated    cells    regulated    selective    questions    create    life    accumulating    technologies    protein    identification    shed    underlying    basis    crack    central    perturbations    genomics    gap    translation    close    synthesis    interdisciplinary    enhancement    mrna    genome    splicing    translational    extreme    thoroughly    changing    environment    opening    mapped    transcription    share    framework    landscape    map    living    translationally    imperative    stress    largely    annotated    mode    stone    environmental    functionally    variety    shut    light    comprehensively    play    regulatory    cis    globally    avenues    discovered    regulation    mrnas    footprint    mammalian    mechanisms    profiling    repression    lagging    uncover    code    upregulate    organisms    cues    kingdoms   

Project "TranslationRegCode" data sheet

The following table provides information about the project.


Organization address
city: HAIFA
postcode: 32000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website
 Total cost 1˙587˙500 €
 EC max contribution 1˙587˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Organisms across all kingdoms share several systems that are essential to life, one of the most central being protein synthesis. Living in a continuously changing environment, cells need to constantly respond to various environmental cues and change their protein landscape. In extreme cases, cells globally shut down protein synthesis and upregulate stress-protective proteins. Mechanisms of translational repression or selective enhancement of stress-induced proteins have been characterized, but their effects were demonstrated on an individual mRNA basis. Which target mRNAs are translationally regulated in response to different environmental cues, and what are the cis-regulatory elements involved, largely remain as open questions. Using ribosome footprint profiling, I recently discovered a novel mode of translational control in stress, underscoring the potential of new technologies to uncover novel regulatory mechanisms. But while transcription cis-regulatory elements have been thoroughly mapped in the past decade, and splicing regulatory elements are accumulating, the identification of translation cis-regulatory elements is lagging behind. Here I propose to crack the mammalian translation regulatory code, and close this long-standing gap. I present a novel interdisciplinary framework to comprehensively identify translation cis-regulatory elements, and map their mRNAs targets in a variety of cellular perturbations. Importantly, we plan to explore mechanisms underlying novel cis-regulatory elements, and create the first genome-wide functionally annotated translation regulatory code. The translation regulatory code will map targets of existing mechanisms and shed light on newly identified pathways that play a role in stress-induced translational control. The proposed project is an imperative stepping stone to understanding translational regulation by cis-regulatory elements, opening new avenues in the functional genomics research of translational control.


year authors and title journal last update
List of publications.
2019 Nir Gonen, Anatoly Meller, Niv Sabath, Reut Shalgi
Amino Acid Biosynthesis Regulation during Endoplasmic Reticulum Stress Is Coupled to Protein Expression Demands
published pages: 204-213, ISSN: 2589-0042, DOI: 10.1016/j.isci.2019.07.022
iScience 19 2019-11-15
2019 Nir Gonen, Niv Sabath, Christopher B. Burge, Reut Shalgi
Widespread PERK-dependent repression of ER targets in response to ER stress
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-38705-5
Scientific Reports 9/1 2019-11-15
2018 Niv Sabath, Anna Vilborg, Joan A. Steitz, Reut Shalgi
Caution needs to be taken when assigning transcription start sites to ends of protein-coding genes: a rebuttal
published pages: , ISSN: 1479-7364, DOI: 10.1186/s40246-018-0164-4
Human Genomics 12/1 2019-11-15
2018 Yuval Wiesel, Niv Sabath, Reut Shalgi
DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4983-4
BMC Genomics 19/1 2019-11-15
2017 Anna Vilborg, Niv Sabath, Yuval Wiesel, Jenny Nathans, Flonia Levy-Adam, Therese A. Yario, Joan A. Steitz, Reut Shalgi
Comparative analysis reveals genomic features of stress-induced transcriptional readthrough
published pages: E8362-E8371, ISSN: 0027-8424, DOI: 10.1073/pnas.1711120114
Proceedings of the National Academy of Sciences 114/40 2019-11-15

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The information about "TRANSLATIONREGCODE" are provided by the European Opendata Portal: CORDIS opendata.

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