Explore the words cloud of the REDOXCYCLE project. It provides you a very rough idea of what is the project "REDOXCYCLE" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITAET DRESDEN
|Coordinator Country||Germany [DE]|
|Total cost||1˙499˙688 €|
|EC max contribution||1˙499˙688 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-07-01 to 2021-06-30|
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|1||TECHNISCHE UNIVERSITAET DRESDEN||DE (DRESDEN)||coordinator||1˙499˙688.00|
Aberrant cell cycle and redox regulation are hallmarks of cancer. While cell cycle and redox signaling are extensively studied, it remains poorly understood how both communicate in physiological conditions. One reason is the emphasis on oxidative stress as a signature of cancer cells. Only recently, emerging evidence indicates that reactive oxygen species (ROS) also function as signaling molecules in physiological conditions, and that some of their key targets are cysteine residues on cell cycle proteins. This indicates that more subtle changes in redox signaling can affect proliferation and have the potential to promote cancer.
I propose to investigate how the cell cycle and redox homeostasis are coupled in a spatial-temporal manner and reveal the differences that distinguish physiological from pathological redox signaling. I will use genetic engineering to label endogenous cell cycle and redox proteins with fluorescent markers. I will measure relative and absolute molecule numbers of cell cycle and redox proteins, relate this to cell cycle and redox states, and determine the cysteines modified on cell cycle proteins. To functionally investigate the pathological potential of identified modifications I will use mammary 3D cell culture – a model that recapitulates many aspects of mammary architecture in vivo and is used to study early steps of breast tumorigenesis.
I expect our work to provide us with a quantitative description of the interface between cell cycle and redox regulation. Although intracellular cell behavior is never completely deterministic, a reasonable quantitative model should be predictive to some degree and reveal how different levels of ROS can affect cell cycle decisions. Shedding light on the cell cycle targets of ROS will indicate the nodes that can be hijacked by cancer cells. Together, this work will provide a significantly improved basis for our understanding of redox signaling in tumorigenesis and indicate new strategies for treatment.
|year||authors and title||journal||last update|
Katrin Daniel, Jaroslav Icha, Cindy Horenburg, Doris MÃ¼ller, Caren Norden, JÃ¶rg Mansfeld
Conditional control of fluorescent protein degradation by an auxin-dependent nanobody
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05855-5
|Nature Communications 9/1||2019-10-09|
Rhys Grant, Ahmed Abdelbaki, Alessia Bertoldi, Maria P. Gavilan, JÃ¶rg Mansfeld, David M. Glover, Catherine Lindon
Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus
published pages: 170272, ISSN: 2046-2441, DOI: 10.1098/rsob.170272
|Open Biology 8/6||2019-10-09|
Thomas Zerjatke, Igor A. Gak, Dilyana Kirova, Markus Fuhrmann, Katrin Daniel, Magdalena Gonciarz, Doris MÃ¼ller, Ingmar Glauche, JÃ¶rg Mansfeld
Quantitative Cell Cycle Analysis Based on an Endogenous All-in-One Reporter for Cell Tracking and Classification
published pages: 1953-1966, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.05.022
|Cell Reports 19/9||2019-06-19|
Ezzaldin Ahmed Alfar, Dilyana Kirova, Judith Konantz, Sarah Birke, JÃ¶rg Mansfeld, Nikolay Ninov
Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03873-9
|Scientific Reports 7/1||2019-06-19|
Lilia Gheghiani, Damarys Loew, BÃ©rangÃ¨re Lombard, JÃ¶rg Mansfeld, Olivier Gavet
PLK1 Activation in Late G2 Sets Up Commitment to Mitosis
published pages: 2060-2073, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.05.031
|Cell Reports 19/10||2019-06-19|
Anna K.L. Liess, Alena Kucerova, Kristian Schweimer, Lu Yu, Theodoros I. Roumeliotis, Mathias Diebold, Olexandr Dybkov, Christoph Sotriffer, Henning Urlaub, Jyoti S. Choudhary, JÃ¶rg Mansfeld, Sonja Lorenz
Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination
published pages: 1195-1210, ISSN: 0969-2126, DOI: 10.1016/j.str.2019.05.008
GÃ¡bor Bakos, Lu Yu, Igor A. Gak, Theodoros I. Roumeliotis, Dimitris Liakopoulos, Jyoti S. Choudhary, JÃ¶rg Mansfeld
An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07251-5
|Nature Communications 9/1||2019-09-05|
Katharina B. Beer, Gholamreza Fazeli, Kristyna Judasova, Linda Irmisch, Jona Causemann, JÃ¶rg Mansfeld, Ann M. Wehman
Degron-tagged reporters probe membrane topology and enable the specific labelling of membrane-wrapped structures
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11442-z
|Nature Communications 10/1||2019-09-05|
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