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NanoPorous DNA-array

Ultra-high density three dimentional DNA arrays for biosensing

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoPorous DNA-array" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.lbb.ethz.ch/the-group/people/person-details.html
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

Map

 Project objective

Extra cellular, circulating nucleic acids – such as DNA or RNA – have been found as important biomarkers for identification and diagnosis of cancer and other diseases However, the detection of circulating nucleic acids is non-trivial because they often exist at very low concentrations in large volumes of body fluids. Although many attempts have been tried for the detection of these biomarkers in recent years, including various nanostructure based sensors, there is still no approach in sight that could reach the desired sensitivity. Hence, there is a great need for a sensor which can effectively detect the diagnostically relevant (low) concentrations of circulating nucleic acids with a high degree of selectivity and sensitivity. In this project we propose a new platform for detection of nucleic acids; the aim of this project is to achieve a multi-layered filtering device, which allows effective filtration, purification and detection of biomolecules from complex biofluids. The platform is based on implementation of ultra-high density 3D DNA arrays - which are made on a functionalized nanoporous substrate (nanoporous anodic aluminium oxide) – into a microfluidic device assay (so called FoRe assay, i.e combination of Forward and Reverse assays, which is consist of multiple filters, each capable of capturing specific target biomarkers from different sample). Pores are able capture the target molecules because locally the concentration of even a single target molecule in the pore is sufficient for binding and hybridization. The captured target molecules can then be detected by subsequent specific labeling using DNA-tagged gold nanoparticles (via hybridization), which will allow detection with single molecule sensitivity. If successful, the scalable system will be used as a point-of-care diagnostic platform in the future.

 Publications

year authors and title journal last update
List of publications.
2017 Morteza Aramesh, Phong A. Tran, Kostya (Ken) Ostrikov, Steven Prawer
Conformal nanocarbon coating of alumina nanocrystals for biosensing and bioimaging
published pages: 422-427, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.06.101
Carbon 122 2019-06-13
2018 Raphael F. Tiefenauer, Klas Tybrandt, Morteza Aramesh, János Vörös
Fast and Versatile Multiscale Patterning by Combining Template-Stripping with Nanotransfer Printing
published pages: 2514-2520, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b08290
ACS Nano 12/3 2019-04-18
2018 Morteza Aramesh
Ion-Beam Sculpting of Nanowires
published pages: 1700333, ISSN: 1862-6254, DOI: 10.1002/pssr.201700333
physica status solidi (RRL) - Rapid Research Letters 12/1 2019-04-18
2018 Raphael F. Tiefenauer, Thomas Dalgaty, Tobias Keplinger, Tian Tian, Chih-Jen Shih, János Vörös, Morteza Aramesh
Monolayer Graphene Coupled to a Flexible Plasmonic Nanograting for Ultrasensitive Strain Monitoring
published pages: 1801187, ISSN: 1613-6810, DOI: 10.1002/smll.201801187
Small 14/28 2019-04-18
2018 Morteza Aramesh, Yashar Mayamei, Annalena Wolff, Kostya Ostrikov
Superplastic nanoscale pore shaping by ion irradiation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03316-7
Nature Communications 9/1 2019-04-18

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