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MICROLIPIDS SIGNED

Microbial lipids: The three domain ‘lipid divide’ revisited

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EC-Contrib. €

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 MICROLIPIDS project word cloud

Explore the words cloud of the MICROLIPIDS project. It provides you a very rough idea of what is the project "MICROLIPIDS" about.

fundamental    glycerols    complemented    genetic    organic    membrane    total    groups    progress    mapping    archaea    involve    tremendous    published    clear    group    identification    acid    acids    ms    hydrolysis    resolution    methodology    liquid    prokaryotes    hplc    straight    evolutionary    question    environmental    characterization    building    glycerol    markers    bacterial    blocks    lipids    samples    whereas    exists    archaeal    biosynthesis    bacteria    data    hidden    characterisation    culture    environment    resolve    spectrometry    ether    analytical    cells    200    microbial    meta    earth    evolution    proxies    life    synthesize    chain    divide    prokaryotic    preliminary    full    dichotomy    contribution    functional    techniques    diacyl    systematically    ipls    domains    lipid    decade    released    sciences    polar    microorganisms    cultures    eukaryotes    fatty    enigmatic    cell    mass    diversity    isoprenoidal    last    genome    perspectives    genes    250    unknown    intact    marginally    made    composition    chromatography    remarkable   

Project "MICROLIPIDS" data sheet

The following table provides information about the project.

Coordinator
STICHTING NIOZ, KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Netherlands [NL]
 Total cost 2˙499˙426 €
 EC max contribution 2˙499˙426 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN NL (UTRECHT) coordinator 2˙499˙426.00
2    STICHTING NIOZ, KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE NL (DEN HOORN TEXEL) coordinator 0.00

Map

 Project objective

Tremendous progress has been made in the last decade in the genetic characterization of microorganisms, both in culture and in the environment. However, our knowledge of microbial membrane lipids, essential building blocks of the cell, has only marginally improved. This is remarkable since there exists a dichotomy in the distribution of lipids between the three Domains of Life. Diacyl glycerols based on straight-chain fatty acids are produced by bacteria and eukaryotes, whereas archaea synthesize isoprenoidal glycerol ether lipids. From a microbial evolutionary perspectives, this ‘lipid divide’ is enigmatic since it has recently become clear that eukaryotes evolved from the archaea. Preliminary results of my research group show that when novel analytical methodology is used, there is a large hidden diversity in microbial lipid composition that may resolve this fundamental question. Here I propose to systematically characterize prokaryotic intact polar lipids (IPLs) with state-of-the-art analytical techniques based on liquid chromatography and high-resolution mass spectrometry to bring our knowledge of microbial lipids to the next level. To this end, we will characterize (i) 250 bacterial and archaeal cultures and (ii) 200 environmental samples for IPLs by HPLC-MS, complemented by full identification of fatty acids and other lipids released after acid hydrolysis of total cells. This approach will be complemented by the characterisation of functional genes for lipid biosynthesis. This will involve both mapping of known genes, based on the analysis of published whole (meta)genome data, as well as the identification of as yet unknown genes in selected groups of prokaryotes. The results are expected to make a fundamental contribution to (i) our understanding of the evolution of biosynthesis of membrane lipids, (ii) their application as microbial markers in the environment, and (iii) in the development and application of organic proxies in earth sciences.

 Publications

year authors and title journal last update
List of publications.
2017 Joong-Jae Kim, Colbran E Marjerrison, Sabrina L Cornish Shartau, Allyson L Brady, Christine E Sharp, W. Irene C Rijpstra, Jaap S Sinninghe Damsté, Peter Schumann, Stephen E Grasby, Peter F Dunfield
Actinocrinis puniceicyclus gen. nov., sp. nov., an actinobacterium isolated from an acidic spring
published pages: 602-609, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.001667
International Journal of Systematic and Evolutionary Microbiology 67/3 2019-10-29
2019 Nadine T. Smit, Darci Rush, Diana X. Sahonero-Canavesi, Monique Verweij, Olivia Rasigraf, Simon Guerrero Cruz, Mike S.M. Jetten, Jaap S. Sinninghe Damsté, Stefan Schouten
Demethylated hopanoids in ‘Ca. Methylomirabilis oxyfera’ as biomarkers for environmental nitrite-dependent methane oxidation
published pages: 103899, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2019.07.008
Organic Geochemistry 137 2019-10-29
2017 Yuki Weber, Jaap S. Sinninghe Damsté, Ellen C. Hopmans, Moritz F. Lehmann, Helge Niemann
Incomplete recovery of intact polar glycerol dialkyl glycerol tetraethers from lacustrine suspended biomass
published pages: 782-793, ISSN: 1541-5856, DOI: 10.1002/lom3.10198
Limnology and Oceanography: Methods 15/9 2019-10-29
2019 Nicole J. Bale, Marton Palatinszky, W. Irene C. Rijpstra, Craig W. Herbold, Michael Wagner, Jaap S. Sinninghe Damsté
Membrane Lipid Composition of the Moderately Thermophilic Ammonia-Oxidizing Archaeon “ Candidatus Nitrosotenuis uzonensis” at Different Growth Temperatures
published pages: , ISSN: 0099-2240, DOI: 10.1128/aem.01332-19
Applied and Environmental Microbiology 85/20 2019-10-29
2019 Nicole J. Bale, Rick Hennekam, Ellen C. Hopmans, Denise Dorhout, Gert-Jan Reichart, Marcel van der Meer, Tracy A. Villareal, Jaap S. Sinninghe Damsté, Stefan Schouten
Biomarker evidence for nitrogen-fixing cyanobacterial blooms in a brackish surface layer in the Nile River plume during sapropel deposition
published pages: 1088-1092, ISSN: 0091-7613, DOI: 10.1130/g46682.1
Geology 47/11 2019-10-28
2018 Peer H. A. Timmers, Charlotte D. Vavourakis, Robbert Kleerebezem, Jaap S. Sinninghe Damsté, Gerard Muyzer, Alfons J. M. Stams, Dimity Y. Sorokin, Caroline M. Plugge
Metabolism and Occurrence of Methanogenic and Sulfate-Reducing Syntrophic Acetate Oxidizing Communities in Haloalkaline Environments
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.03039
Frontiers in Microbiology 9 2019-09-04
2019 Sergio Balzano, Laura Villanueva, Marijke de Bar, Diana X Sahonero Canavesi, Caglar Yildiz, Julia C Engelmann, Eric Marechal, Josselin Lupette, Jaap S Sinninghe Damsté, Stefan Schouten
Biosynthesis of Long Chain Alkyl Diols and Long Chain Alkenols in Nannochloropsis spp. (Eustigmatophyceae)
published pages: , ISSN: 0032-0781, DOI: 10.1093/pcp/pcz078
Plant and Cell Physiology 2019-09-04
2019 Marc A. Besseling, Ellen C. Hopmans, Michel Koenen, Marcel T.J. van der Meer, Sanne Vreugdenhil, Stefan Schouten, Jaap S. Sinninghe Damsté, Laura Villanueva
Depth-related differences in archaeal populations impact the isoprenoid tetraether lipid composition of the Mediterranean Sea water column
published pages: 16-31, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2019.06.008
Organic Geochemistry 135 2019-09-04
2018 Jaap S. Sinninghe Damsté, W. Irene C. Rijpstra, Bärbel U. Foesel, Katharina J. Huber, Jörg Overmann, Satoshi Nakagawa, Joong Jae Kim, Peter F. Dunfield, Svetlana N. Dedysh, Laura Villanueva
An overview of the occurrence of ether- and ester-linked iso-diabolic acid membrane lipids in microbial cultures of the Acidobacteria: Implications for brGDGT paleoproxies for temperature and pH
published pages: 63-76, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2018.07.006
Organic Geochemistry 124 2019-09-04
2019 Dimitry Y. Sorokin, Mikhail Yakimov, Enzo Messina, Alexander Y. Merkel, Nicole J. Bale, Jaap S. Sinninghe Damsté
Natronolimnobius sulfurireducens sp. nov. and Halalkaliarchaeum desulfuricum gen. nov., sp. nov., the first sulfur-respiring alkaliphilic haloarchaea from hypersaline alkaline lakes
published pages: , ISSN: 1466-5026, DOI: 10.1099/ijsem.0.003506
International Journal of Systematic and Evolutionary Microbiology 2019-09-04
2019 Igor Y. Oshkin, Irina S. Kulichevskaya, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Andrey L. Rakitin, Nikolai V. Ravin, Svetlana N. Dedysh
Granulicella sibirica sp. nov., a psychrotolerant acidobacterium isolated from an organic soil layer in forested tundra, West Siberia
published pages: 1195-1201, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.003290
International Journal of Systematic and Evolutionary Microbiology 69/4 2019-09-04
2019 Dimitry Y. Sorokin, Tatiana V. Khijniak, Alexander G. Elcheninov, Stepan V. Toshchakov, Nadezhda A. Kostrikina, Nicole J. Bale, Jaap S. Sinninghe Damsté, Ilya V. Kublanov
Halococcoides cellulosivorans gen. nov., sp. nov., an extremely halophilic cellulose-utilizing haloarchaeon from hypersaline lakes
published pages: 1327-1335, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.003312
International Journal of Systematic and Evolutionary Microbiology 69/5 2019-09-04
2019 Nicole J. Bale, W. Irene C. Rijpstra, Diana X. Sahonero-Canavesi, Igor Y. Oshkin, Svetlana E. Belova, Svetlana N. Dedysh, Jaap S. Sinninghe Damsté
Fatty Acid and Hopanoid Adaption to Cold in the Methanotroph Methylovulum psychrotolerans
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00589
Frontiers in Microbiology 10 2019-09-04
2018 Marc A. Besseling, Ellen C. Hopmans, R. Christine Boschman, Jaap S. Sinninghe Damsté, Laura Villanueva
Benthic archaea as potential sources of tetraether membrane lipids in sediments across an oxygen minimum zone
published pages: 4047-4064, ISSN: 1726-4189, DOI: 10.5194/bg-15-4047-2018
Biogeosciences 15/13 2019-09-04
2019 Dimitry Y. Sorokin, Alexander G. Elcheninov, Stepan V. Toshchakov, Nicole J. Bale, Jaap S. Sinninghe Damsté, Tatiana V. Khijniak, Ilya V. Kublanov
Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius halalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes
published pages: 309-318, ISSN: 0723-2020, DOI: 10.1016/j.syapm.2019.01.001
Systematic and Applied Microbiology 42/3 2019-09-04
2018 Yuki Weber, Jaap S. Sinninghe Damsté, Jakob Zopfi, Cindy De Jonge, Adrian Gilli, Carsten J. Schubert, Fabio Lepori, Moritz F. Lehmann, Helge Niemann
Redox-dependent niche differentiation provides evidence for multiple bacterial sources of glycerol tetraether lipids in lakes
published pages: 10926-10931, ISSN: 0027-8424, DOI: 10.1073/pnas.1805186115
Proceedings of the National Academy of Sciences 115/43 2019-09-04
2018 Fauziah F. Rochman, Joong-Jae Kim, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Peter Schumann, Tobin J. Verbeke, Peter F. Dunfield
Oleiharenicola alkalitolerans gen. nov., sp. nov., a new member of the phylum Verrucomicrobia isolated from an oilsands tailings pond
published pages: 1078-1084, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.002624
International Journal of Systematic and Evolutionary Microbiology 68/4 2019-09-04
2018 Svetlana E. Belova, Natalia E. Suzina, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Svetlana N. Dedysh
Edaphobacter lichenicola sp. nov., a member of the family Acidobacteriaceae from lichen-dominated forested tundra
published pages: 1265-1270, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.002663
International Journal of Systematic and Evolutionary Microbiology 68/4 2019-09-04
2019 Nicole J. Bale, Dimitry Y. Sorokin, Ellen C. Hopmans, Michel Koenen, W. Irene C. Rijpstra, Laura Villanueva, Hans Wienk, Jaap S. Sinninghe Damsté
New Insights Into the Polar Lipid Composition of Extremely Halo(alkali)philic Euryarchaea From Hypersaline Lakes
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00377
Frontiers in Microbiology 10 2019-09-04
2018 Dimitry Y. Sorokin, Tatiana V. Khijniak, Nadezhda A. Kostrikina, Alexander G. Elcheninov, Stepan V. Toshchakov, Nicole J. Bale, Jaap S. Sinninghe Damsté, Ilya V. Kublanov
Natronobiforma cellulositropha gen. nov., sp. nov., a novel haloalkaliphilic member of the family Natrialbaceae (class Halobacteria) from hypersaline alkaline lakes
published pages: 355-362, ISSN: 0723-2020, DOI: 10.1016/j.syapm.2018.04.002
Systematic and Applied Microbiology 41/4 2019-09-04
2017 Darci Rush, Jaap S. Sinninghe Damsté
Lipids as paleomarkers to constrain the marine nitrogen cycle
published pages: 2119-2132, ISSN: 1462-2912, DOI: 10.1111/1462-2920.13682
Environmental Microbiology 19/6 2019-09-04
2017 Jaap S. Sinninghe Damsté, W. Irene C. Rijpstra, Svetlana N. Dedysh, Bärbel U. Foesel, Laura Villanueva
Pheno- and Genotyping of Hopanoid Production in Acidobacteria
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00968
Frontiers in Microbiology 8 2019-09-04

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