MICROLIPIDS SIGNED
Microbial lipids: The three domain ‘lipid divide’ revisited
Total Cost €
0EC-Contrib. €
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Project "MICROLIPIDS" data sheet
The following table provides information about the project.
| Coordinator |
STICHTING NIOZ, KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE
There are not information about this coordinator. Please contact Fabio for more information, thanks. |
| Coordinator Country | Netherlands [NL] |
| Total cost | 2˙499˙426 € |
| EC max contribution | 2˙499˙426 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN | NL (UTRECHT) | coordinator | 2˙499˙426.00 |
| 2 | STICHTING NIOZ, KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE | NL (DEN HOORN TEXEL) | coordinator | 0.00 |
Map
Project objective
Tremendous progress has been made in the last decade in the genetic characterization of microorganisms, both in culture and in the environment. However, our knowledge of microbial membrane lipids, essential building blocks of the cell, has only marginally improved. This is remarkable since there exists a dichotomy in the distribution of lipids between the three Domains of Life. Diacyl glycerols based on straight-chain fatty acids are produced by bacteria and eukaryotes, whereas archaea synthesize isoprenoidal glycerol ether lipids. From a microbial evolutionary perspectives, this ‘lipid divide’ is enigmatic since it has recently become clear that eukaryotes evolved from the archaea. Preliminary results of my research group show that when novel analytical methodology is used, there is a large hidden diversity in microbial lipid composition that may resolve this fundamental question. Here I propose to systematically characterize prokaryotic intact polar lipids (IPLs) with state-of-the-art analytical techniques based on liquid chromatography and high-resolution mass spectrometry to bring our knowledge of microbial lipids to the next level. To this end, we will characterize (i) 250 bacterial and archaeal cultures and (ii) 200 environmental samples for IPLs by HPLC-MS, complemented by full identification of fatty acids and other lipids released after acid hydrolysis of total cells. This approach will be complemented by the characterisation of functional genes for lipid biosynthesis. This will involve both mapping of known genes, based on the analysis of published whole (meta)genome data, as well as the identification of as yet unknown genes in selected groups of prokaryotes. The results are expected to make a fundamental contribution to (i) our understanding of the evolution of biosynthesis of membrane lipids, (ii) their application as microbial markers in the environment, and (iii) in the development and application of organic proxies in earth sciences.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Joong-Jae Kim, Colbran E Marjerrison, Sabrina L Cornish Shartau, Allyson L Brady, Christine E Sharp, W. Irene C Rijpstra, Jaap S Sinninghe Damsté, Peter Schumann, Stephen E Grasby, Peter F Dunfield Actinocrinis puniceicyclus gen. nov., sp. nov., an actinobacterium isolated from an acidic spring published pages: 602-609, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.001667 |
International Journal of Systematic and Evolutionary Microbiology 67/3 | 2019-10-29 |
| 2019 |
Nadine T. Smit, Darci Rush, Diana X. Sahonero-Canavesi, Monique Verweij, Olivia Rasigraf, Simon Guerrero Cruz, Mike S.M. Jetten, Jaap S. Sinninghe Damsté, Stefan Schouten Demethylated hopanoids in ‘Ca. Methylomirabilis oxyfera’ as biomarkers for environmental nitrite-dependent methane oxidation published pages: 103899, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2019.07.008 |
Organic Geochemistry 137 | 2019-10-29 |
| 2017 |
Yuki Weber, Jaap S. Sinninghe Damsté, Ellen C. Hopmans, Moritz F. Lehmann, Helge Niemann Incomplete recovery of intact polar glycerol dialkyl glycerol tetraethers from lacustrine suspended biomass published pages: 782-793, ISSN: 1541-5856, DOI: 10.1002/lom3.10198 |
Limnology and Oceanography: Methods 15/9 | 2019-10-29 |
| 2019 |
Nicole J. Bale, Marton Palatinszky, W. Irene C. Rijpstra, Craig W. Herbold, Michael Wagner, Jaap S. Sinninghe Damsté Membrane Lipid Composition of the Moderately Thermophilic Ammonia-Oxidizing Archaeon “ Candidatus Nitrosotenuis uzonensis†at Different Growth Temperatures published pages: , ISSN: 0099-2240, DOI: 10.1128/aem.01332-19 |
Applied and Environmental Microbiology 85/20 | 2019-10-29 |
| 2019 |
Nicole J. Bale, Rick Hennekam, Ellen C. Hopmans, Denise Dorhout, Gert-Jan Reichart, Marcel van der Meer, Tracy A. Villareal, Jaap S. Sinninghe Damsté, Stefan Schouten Biomarker evidence for nitrogen-fixing cyanobacterial blooms in a brackish surface layer in the Nile River plume during sapropel deposition published pages: 1088-1092, ISSN: 0091-7613, DOI: 10.1130/g46682.1 |
Geology 47/11 | 2019-10-28 |
| 2018 |
Peer H. A. Timmers, Charlotte D. Vavourakis, Robbert Kleerebezem, Jaap S. Sinninghe Damsté, Gerard Muyzer, Alfons J. M. Stams, Dimity Y. Sorokin, Caroline M. Plugge Metabolism and Occurrence of Methanogenic and Sulfate-Reducing Syntrophic Acetate Oxidizing Communities in Haloalkaline Environments published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.03039 |
Frontiers in Microbiology 9 | 2019-09-04 |
| 2019 |
Sergio Balzano, Laura Villanueva, Marijke de Bar, Diana X Sahonero Canavesi, Caglar Yildiz, Julia C Engelmann, Eric Marechal, Josselin Lupette, Jaap S Sinninghe Damsté, Stefan Schouten Biosynthesis of Long Chain Alkyl Diols and Long Chain Alkenols in Nannochloropsis spp. (Eustigmatophyceae) published pages: , ISSN: 0032-0781, DOI: 10.1093/pcp/pcz078 |
Plant and Cell Physiology | 2019-09-04 |
| 2019 |
Marc A. Besseling, Ellen C. Hopmans, Michel Koenen, Marcel T.J. van der Meer, Sanne Vreugdenhil, Stefan Schouten, Jaap S. Sinninghe Damsté, Laura Villanueva Depth-related differences in archaeal populations impact the isoprenoid tetraether lipid composition of the Mediterranean Sea water column published pages: 16-31, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2019.06.008 |
Organic Geochemistry 135 | 2019-09-04 |
| 2018 |
Jaap S. Sinninghe Damsté, W. Irene C. Rijpstra, Bärbel U. Foesel, Katharina J. Huber, Jörg Overmann, Satoshi Nakagawa, Joong Jae Kim, Peter F. Dunfield, Svetlana N. Dedysh, Laura Villanueva An overview of the occurrence of ether- and ester-linked iso-diabolic acid membrane lipids in microbial cultures of the Acidobacteria: Implications for brGDGT paleoproxies for temperature and pH published pages: 63-76, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2018.07.006 |
Organic Geochemistry 124 | 2019-09-04 |
| 2019 |
Dimitry Y. Sorokin, Mikhail Yakimov, Enzo Messina, Alexander Y. Merkel, Nicole J. Bale, Jaap S. Sinninghe Damsté Natronolimnobius sulfurireducens sp. nov. and Halalkaliarchaeum desulfuricum gen. nov., sp. nov., the first sulfur-respiring alkaliphilic haloarchaea from hypersaline alkaline lakes published pages: , ISSN: 1466-5026, DOI: 10.1099/ijsem.0.003506 |
International Journal of Systematic and Evolutionary Microbiology | 2019-09-04 |
| 2019 |
Igor Y. Oshkin, Irina S. Kulichevskaya, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Andrey L. Rakitin, Nikolai V. Ravin, Svetlana N. Dedysh Granulicella sibirica sp. nov., a psychrotolerant acidobacterium isolated from an organic soil layer in forested tundra, West Siberia published pages: 1195-1201, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.003290 |
International Journal of Systematic and Evolutionary Microbiology 69/4 | 2019-09-04 |
| 2019 |
Dimitry Y. Sorokin, Tatiana V. Khijniak, Alexander G. Elcheninov, Stepan V. Toshchakov, Nadezhda A. Kostrikina, Nicole J. Bale, Jaap S. Sinninghe Damsté, Ilya V. Kublanov Halococcoides cellulosivorans gen. nov., sp. nov., an extremely halophilic cellulose-utilizing haloarchaeon from hypersaline lakes published pages: 1327-1335, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.003312 |
International Journal of Systematic and Evolutionary Microbiology 69/5 | 2019-09-04 |
| 2019 |
Nicole J. Bale, W. Irene C. Rijpstra, Diana X. Sahonero-Canavesi, Igor Y. Oshkin, Svetlana E. Belova, Svetlana N. Dedysh, Jaap S. Sinninghe Damsté Fatty Acid and Hopanoid Adaption to Cold in the Methanotroph Methylovulum psychrotolerans published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00589 |
Frontiers in Microbiology 10 | 2019-09-04 |
| 2018 |
Marc A. Besseling, Ellen C. Hopmans, R. Christine Boschman, Jaap S. Sinninghe Damsté, Laura Villanueva Benthic archaea as potential sources of tetraether membrane lipids in sediments across an oxygen minimum zone published pages: 4047-4064, ISSN: 1726-4189, DOI: 10.5194/bg-15-4047-2018 |
Biogeosciences 15/13 | 2019-09-04 |
| 2019 |
Dimitry Y. Sorokin, Alexander G. Elcheninov, Stepan V. Toshchakov, Nicole J. Bale, Jaap S. Sinninghe Damsté, Tatiana V. Khijniak, Ilya V. Kublanov Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius halalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes published pages: 309-318, ISSN: 0723-2020, DOI: 10.1016/j.syapm.2019.01.001 |
Systematic and Applied Microbiology 42/3 | 2019-09-04 |
| 2018 |
Yuki Weber, Jaap S. Sinninghe Damsté, Jakob Zopfi, Cindy De Jonge, Adrian Gilli, Carsten J. Schubert, Fabio Lepori, Moritz F. Lehmann, Helge Niemann Redox-dependent niche differentiation provides evidence for multiple bacterial sources of glycerol tetraether lipids in lakes published pages: 10926-10931, ISSN: 0027-8424, DOI: 10.1073/pnas.1805186115 |
Proceedings of the National Academy of Sciences 115/43 | 2019-09-04 |
| 2018 |
Fauziah F. Rochman, Joong-Jae Kim, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Peter Schumann, Tobin J. Verbeke, Peter F. Dunfield Oleiharenicola alkalitolerans gen. nov., sp. nov., a new member of the phylum Verrucomicrobia isolated from an oilsands tailings pond published pages: 1078-1084, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.002624 |
International Journal of Systematic and Evolutionary Microbiology 68/4 | 2019-09-04 |
| 2018 |
Svetlana E. Belova, Natalia E. Suzina, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Svetlana N. Dedysh Edaphobacter lichenicola sp. nov., a member of the family Acidobacteriaceae from lichen-dominated forested tundra published pages: 1265-1270, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.002663 |
International Journal of Systematic and Evolutionary Microbiology 68/4 | 2019-09-04 |
| 2019 |
Nicole J. Bale, Dimitry Y. Sorokin, Ellen C. Hopmans, Michel Koenen, W. Irene C. Rijpstra, Laura Villanueva, Hans Wienk, Jaap S. Sinninghe Damsté New Insights Into the Polar Lipid Composition of Extremely Halo(alkali)philic Euryarchaea From Hypersaline Lakes published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00377 |
Frontiers in Microbiology 10 | 2019-09-04 |
| 2018 |
Dimitry Y. Sorokin, Tatiana V. Khijniak, Nadezhda A. Kostrikina, Alexander G. Elcheninov, Stepan V. Toshchakov, Nicole J. Bale, Jaap S. Sinninghe Damsté, Ilya V. Kublanov Natronobiforma cellulositropha gen. nov., sp. nov., a novel haloalkaliphilic member of the family Natrialbaceae (class Halobacteria) from hypersaline alkaline lakes published pages: 355-362, ISSN: 0723-2020, DOI: 10.1016/j.syapm.2018.04.002 |
Systematic and Applied Microbiology 41/4 | 2019-09-04 |
| 2017 |
Darci Rush, Jaap S. Sinninghe Damsté Lipids as paleomarkers to constrain the marine nitrogen cycle published pages: 2119-2132, ISSN: 1462-2912, DOI: 10.1111/1462-2920.13682 |
Environmental Microbiology 19/6 | 2019-09-04 |
| 2017 |
Jaap S. Sinninghe Damsté, W. Irene C. Rijpstra, Svetlana N. Dedysh, Bärbel U. Foesel, Laura Villanueva Pheno- and Genotyping of Hopanoid Production in Acidobacteria published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00968 |
Frontiers in Microbiology 8 | 2019-09-04 |
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