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Immune Regulation SIGNED

How Infection History Shapes the Immune System: Pathogen-induced Changes in Regulatory T Cells

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Immune Regulation" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: Zürich
postcode: 8006
website: http://www.unizh.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.immunology.uzh.ch/en/researchunit/immuneregulation.html
 Total cost 1˙499˙755 €
 EC max contribution 1˙499˙755 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (Zürich) coordinator 1˙499˙755.00

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 Project objective

Studying host-pathogen interactions by focusing on the interaction of a single pathogen with the host has defined our understanding of these events and the insights gained form the basis for the therapeutic and vaccination strategies we use today. However, people become infected with multiple pathogens throughout their lifetime, at times even simultaneously. Still, it is largely unknown how the immune response to one pathogen alters the body’s ability to respond to a second infectious agent or the susceptibility to autoimmunity or cancer. This project will address this question by focusing on infection-induced changes in regulatory T cells (Tregs) as they may lead to biased suppression and changes in the nature of subsequent immune responses. Our efforts will focus on two areas: In a first part, we will use single cell RNA-Seq to address how infections shape the Treg compartment by defining the specialized Treg subsets generated during polarized infectious settings and analyzing how they interact with effector T cells. Based on the depth of information we expect to obtain from this approach, we envisage finding thus far unappreciated interactions and functions of Tregs in the course of an immune response. The second part will investigate how an altered Treg compartment, either through genetic modifications or infection-induced, affects disease susceptibility. In this context, we will also address stability and persistence of pathogen-induced changes in the Treg compartment. Collectively the proposed experiments will allow us to start addressing how preceding infections affect disease susceptibility. Deciphering how infection history shapes the Treg compartment and how this affects susceptibility to future challenges will lay the groundwork for addressing this question more broadly in the future and as such will likely have a transformative impact on the field.

 Publications

year authors and title journal last update
List of publications.
2020 Michelle Schorer, Nikolas Rakebrandt, Katharina Lambert, Annika Hunziker, Katharina Pallmer, Annette Oxenius, Anja Kipar, Silke Stertz, Nicole Joller
TIGIT limits immune pathology during viral infections
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-020-15025-1
Nature Communications 11/1 2020-04-24
2019 Florian R. Kirchner, Katharina Littringer, Simon Altmeier, Van Du T. Tran, Franziska Schönherr, Christina Lemberg, Marco Pagni, Dominique Sanglard, Nicole Joller, Salomé LeibundGut-Landmann
Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00330
Frontiers in Immunology 10 2020-04-24
2020 Michelle Schorer, Katharina Lambert, Nikolas Rakebrandt, Felix Rost, Kung-Chi Kao, Alexander Yermanos, Roman Spörri, Josua Oderbolz, Miro E. Raeber, Christian W. Keller, Jan D. Lünemann, Gerhard Rogler, Onur Boyman, Annette Oxenius, Nicole Joller
Rapid expansion of Treg cells protects from collateral colitis following a viral trigger
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-020-15309-6
Nature Communications 11/1 2020-04-24
2018 Katharina Littringer, Claudia Moresi, Nikolas Rakebrandt, Xiaobei Zhou, Michelle Schorer, Tamas Dolowschiak, Florian Kirchner, Felix Rost, Christian W. Keller, Donal McHugh, Salomé LeibundGut-Landmann, Mark D. Robinson, Nicole Joller
Common Features of Regulatory T Cell Specialization During Th1 Responses
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01344
Frontiers in Immunology 9 2019-07-08
2016 Yasuhiro Kishi, Takaaki Kondo, Sheng Xiao, Nir Yosef, Jellert Gaublomme, Chuan Wu, Chao Wang, Norio Chihara, Aviv Regev, Nicole Joller, Vijay K. Kuchroo
Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity
published pages: 2489-2501, ISSN: 0022-1007, DOI: 10.1084/jem.20151118
The Journal of Experimental Medicine 213/11 2019-07-08
2017 Nicole Joller, Vijay K. Kuchroo
Tim-3, Lag-3, and TIGIT.
published pages: 127-156, ISSN: , DOI: 10.1007/82_2017_62
Current Topics in Microbiology and Immunology 2019-07-08
2019 Nikolas Rakebrandt, Nicole Joller
Infection History Determines Susceptibility to Unrelated Diseases
published pages: 1800191, ISSN: 0265-9247, DOI: 10.1002/bies.201800191
BioEssays 41/6 2019-09-02
2019 Florian R. Kirchner, Katharina Littringer, Simon Altmeier, Van Du T. Tran, Franziska Schönherr, Christina Lemberg, Marco Pagni, Dominique Sanglard, Nicole Joller, Salomé LeibundGut-Landmann
Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00330
Frontiers in Immunology 10 2019-09-04
2016 N Rakebrandt, K Littringer, N Joller
Regulatory T cells: balancing protection versus pathology
published pages: , ISSN: 1424-7860, DOI: 10.4414/smw.2016.14343
Swiss Medical Weekly 2019-07-08
2019 Florian Sparber, Corinne De Gregorio, Simone Steckholzer, Filipa M. Ferreira, Tamas Dolowschiak, Fiorella Ruchti, Florian R. Kirchner, Sarah Mertens, Immo Prinz, Nicole Joller, Thorsten Buch, Martin Glatz, Federica Sallusto, Salomé LeibundGut-Landmann
The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation
published pages: 389-403.e6, ISSN: 1931-3128, DOI: 10.1016/j.chom.2019.02.002
Cell Host & Microbe 25/3 2019-09-02
2018 Karen O. Dixon, Michelle Schorer, James Nevin, Yassaman Etminan, Zohreh Amoozgar, Takaaki Kondo, Sema Kurtulus, Nasim Kassam, Raymond A. Sobel, Dai Fukumura, Rakesh K. Jain, Ana C. Anderson, Vijay K. Kuchroo, Nicole Joller
Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity
published pages: 3000-3007, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1700407
The Journal of Immunology 200/8 2019-07-08
2018 Florian Sparber, Tamas Dolowschiak, Sarah Mertens, Laura Lauener, Björn E. Clausen, Nicole Joller, Patrizia Stoitzner, Roxane Tussiwand, Salomé LeibundGut-Landmann
Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection
published pages: e1007069, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007069
PLOS Pathogens 14/5 2019-07-08

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