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EXPHYLL SIGNED

Discovery of new herbicides through an exploration of the chemistry and biology of the naturally occurring phyllostictines

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EXPHYLL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://warwick.ac.uk/fac/sci/chemistry/research/shipman/shipmangroup/research
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 195˙454.00

Map

 Project objective

Phyllostictine A (PA) is the most potent member of a new class of natural product isolated from the fungus phyllosticta cirsii that displays strong herbicidal activity and is an exciting new lead in crop protection. Martin Riemer (PhD 2014, University of Potsdam, Germany) will undertake the first chemical synthesis of phyllostictine A (PA) at the University of Warwick, UK and participate in a multi-disciplinary project that spans the interface between chemistry and biology. PA constitutes a formidable synthetic challenge and its synthesis will require him to develop a variety of new chemical reactions and processes. Emphasis will be placed on sustainable, catalytic transformations and on adhering to the principles of the ‘ideal’ synthesis (e.g. atom, step and redox economy), work which builds directly on the applicant’s skills and expertise. Through a secondment to Rothamsted Research, Riemer will broaden his knowledge base by testing a selection of synthetic analogues against invasive weeds. Taken together, these activities will advance our understanding of the mode of action of PA, and pave the way for the development of simplified analogues for use in agriculture. Moreover, through the planned training and mentoring activities, Riemer will develop into an outstanding early career researcher of great potential.

 Publications

year authors and title journal last update
List of publications.
2018 Martin Riemer, Veselina V. Uzunova, Nastja Riemer, Guy J. Clarkson, Nicole Pereira, Richard Napier, Michael Shipman
Phyllostictine A: total synthesis, structural verification and determination of substructure responsible for plant growth inhibition
published pages: , ISSN: 1359-7345, DOI: 10.1039/C8CC03349H
Chemical Communications 2019-06-13

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