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Lumiblast SIGNED

A paradigm shift in cancer therapy – using mitochondria-powered chemiluminescence to non-invasively treat inaccessible tumours

Total Cost €

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EC-Contrib. €

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Partnership

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 Lumiblast project word cloud

Explore the words cloud of the Lumiblast project. It provides you a very rough idea of what is the project "Lumiblast" about.

formulation    cancers    glioblastoma    knight    cranium    sources    team    pharmaceutical    hanne    resection    concerted    sme    polytechnic    lumiblast    animal    invasiveness    nnensen    uoa    clinic    valencia    georgios    least    small    synthetic    ros    extracellular    photosensitizers    oslash    cm    external    photons    activating    incurable       nature    record    killing    vougioukalakis    coming    impressive    models    inside    vision    chemiluminescence    eliminate    utilized    miguel    university    interdisciplinary    treatments    headed    expertise    clinically    renowned    inaccessible    tumors    scientific    specialized    individual    oslo    photochemistry    photodynamic    luminescence    multiforme    berg    ksl    location    jan    invasive    breakthrough    ous    ltd    deep    activated    cells    usually    leader    origins    form    lesion    practically    treat    light    surgery    hitherto    cell    spread    margin    lamp    athens    upv    proof    limited    cultures    brain    chemistry    gbm    pdt    photon    agents    therapy    uio    world    track    tumour    mainly    penetration    collective    limitation    solid    photomedicine    miranda    aggressive    localized    photosensitive    tumor    tissue    hospital    act    ceo    group    efficient    action    avoiding    completely    sited   

Project "Lumiblast" data sheet

The following table provides information about the project.

Coordinator
OSLO UNIVERSITETSSYKEHUS HF 

Organization address
address: KIRKEVEIEN 166 TARNBYGGET
city: OSLO
postcode: 450
website: http://www.oslo-universitetssykehus.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website http://www.lumiblast.eu
 Total cost 3˙031˙375 €
 EC max contribution 3˙031˙375 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) coordinator 1˙306˙375.00
2    KNIGHT SCIENTIFIC LIMITED UK (PLYMOUTH DEVON) participant 477˙500.00
3    UNIVERSITAT POLITECNICA DE VALENCIA ES (VALENCIA) participant 424˙375.00
4    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) participant 413˙125.00
5    UNIVERSITETET I OSLO NO (OSLO) participant 410˙000.00

Map

 Project objective

Brain cancers such as glioblastoma multiforme (GBM) are practically incurable due to their location, invasiveness and highly aggressive nature. The use of light-based treatments of GBM by activating tumor-localized photosensitizers, such as in photodynamic therapy (PDT) has been clinically evaluated, but with limited success. This is mainly due to the limited penetration of light into tissue and the efficient spread of tumor cells typically up to at least 2 cm from the resection margin. Moreover, the existing photon based treatments (photodynamic therapy) are highly invasive and usually require open-cranium surgery, due to the need for external light sources. In the Lumiblast project the photons are produced inside the tumor cells in the form of chemiluminescence avoiding the major limitation of using external light to treat solid, deep-sited and inaccessible tumors. The principle utilized in Lumiblast may also be relevant for cancers of other origins. Due to its nature Lumiblast is expected to act on individual cells, rather than the collective lesion; it could thus completely eliminate the hitherto incurable GBM. Each GBM cell is expected to become a small lamp providing the light required for the photosensitive agents to become activated, killing the tumour cells from the inside. Lumiblast requires a concerted interdisciplinary action. The project coordinator (Berg’s group, Oslo University Hospital, OUS) is world renowned in PDT and photomedicine, while the team from the University of Athens (Georgios Vougioukalakis’ group, UoA) is up and coming with high expertise in synthetic chemistry. The Polytechnic University of Valencia (Miguel Miranda’s group, UPV) team is headed by a world leader in Photochemistry, the University of Oslo partner (Hanne H. Tønnensen’s group, UiO) is specialized in pharmaceutical formulation, and Knight Scientific Ltd (KSL, CEO Jan Knight) is an SME with an impressive track record in ROS-activated luminescence. This 4.5-year project will establish the Lumiblast breakthrough technology by providing proof-of-concept in extracellular systems, GBM cell cultures and animal models, with the vision to advance Lumiblast to the clinic 5-6 years after the end of the proposed project.

 Deliverables

List of deliverables.
Project website Websites, patent fillings, videos etc. 2019-05-31 16:51:01

Take a look to the deliverables list in detail:  detailed list of Lumiblast deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Pantelia, Daskalaki, Cuquerella, Rotas, Miranda, Vougioukalakis
Synthesis and Chemiluminescent Properties of Amino-Acylated luminol Derivatives Bearing Phosphonium Cations
published pages: 3957, ISSN: 1420-3049, DOI: 10.3390/molecules24213957
Molecules 24/21 2020-04-04
2020 Mantas Grigalavicius, Maria Mastrangelopoulou, Delmon Arous, Asta Juzeniene, Mathilde Ménard, Ellen Skarpen, Kristian Berg, Theodossis A. Theodossiou
Photodynamic efficacy of cercosporin in 3D tumor cell cultures
published pages: , ISSN: 0031-8655, DOI: 10.1111/php.13257
Photochemistry and Photobiology 2020-04-04
2019 Maria Mastrangelopoulou, Mantas Grigalavicius, Kristian Berg, Mathilde Ménard, Theodossis A. Theodossiou
Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
published pages: 387-396, ISSN: 0031-8655, DOI: 10.1111/php.12997
Photochemistry and Photobiology 95/1 2019-04-18

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The information about "LUMIBLAST" are provided by the European Opendata Portal: CORDIS opendata.

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