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A cartridge based flow chemistry machine for the automated synthesis of N-heterocycles for drug discovery

Total Cost €


EC-Contrib. €






 HETSPRESSO project word cloud

Explore the words cloud of the HETSPRESSO project. It provides you a very rough idea of what is the project "HETSPRESSO" about.

snap    erc    chemical    business    few    prototype    synthetic    protection    setups    follow    principles    workups    start    automated    reaction    translate    indicative    chemistries    margins    longer    attractive    clear    innovative    revenue    scaffolds    reagents    purchase    stream    efforts    ip    begun    difficult    sufficient    feedback    emerge    disposable    drug    class    relatively    prepare    commercialized    disadvantages    stand    cartridges    successfully    initial    cartridge    rapid    safe    compounds    conducting    provides    parties    entity    valuable    complicated    instruments    sustainable    sale    poc    reagent    optimizing    machines    pharmaceuticals    convenient    startup    first    methodology    assemble    despite    alleviate    marketing    times    company    sought    basis    materials    toxic    machine    heterocycles    manner    alone    demand    successful    roadmap    sales    chemistry    operation    generation    saturated    synthesis    establishing    assembly    proprietary   

Project "HETSPRESSO" data sheet

The following table provides information about the project.


Organization address
address: Raemistrasse 101
postcode: 8092

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 149˙040 €
 EC max contribution 149˙040 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2018-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Saturated N-heterocycles are an important class of compounds and are attractive as scaffolds in the development of new pharmaceuticals. As part of ERC supported research, we identified a new class of chemical reagents – “SnAP Reagents” – that alleviate previous synthetic challenges. These SnAP reagents enable the synthesis of more drug-like saturated N-heterocycles, including some of the most sought after, but most difficult to prepare scaffolds. They have been successfully commercialized and are in high demand.

This high consumer demand, which is indicative of the interest in these products, is despite the disadvantages of this methodology: use of toxic materials, long reaction times, and relatively complicated reaction setups and workups. Furthermore, the sales of the reagents – while successful – have low margins and there are few opportunities for IP protection. We have therefore begun development of an innovative, cartridge-based, fully automated, stand-alone machine for conducting SnAP chemistry in a safe, rapid, and convenient manner. This approach provides a clear roadmap for a sustainable, successful Startup Entity by the development and sale of proprietary machines and disposable cartridges.

The ERC PoC funding will be used to assemble sufficient prototype machines and develop disposable cartridges for initial sales and marketing efforts. The successful assembly of a working prototype will provide the basis for the sale of first generation machines and a revenue stream for establishing a sustainable business. We have already identified interested parties who will purchase the first-generation instruments and provide valuable feedback for improving and optimizing their operation. In the longer-term, it is expected that sales of the disposable reagent cartridges and development of new machines that follow the same principles will emerge as the main activities of the start up company. We will also translate the technology and IP to other chemistries.

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The information about "HETSPRESSO" are provided by the European Opendata Portal: CORDIS opendata.

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