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TRIGEM

Unlocking Triterpenoid Structural Diversity and Bioactivity through Genome Mining

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TRIGEM" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.jic.ac.uk/directory/anne-osbourn/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 183˙454.00

Map

 Project objective

The triterpenoids are one of the largest and most structurally complex plant natural products. They are widespread in the Plant Kingdom and have a huge array of structures and numerous associated biological activities. They have important roles in plant defence and signalling. They are also exploited by humans as food supplements, drugs and cosmetics across various sectors. In the past the discovery and production of triterpenoids has relied mainly on isolation from extracts of natural sources and subsequent structural elucidation and chemical modification. These methods suffer from low efficiency and high cost, and are not environmentally sustainable. We herein propose a greener and more sustainable but as yet largely unexplored synthetic biology-based approach that involves genome mining and metabolic engineering to synthesise structural variants of triterpenoids, with a view to discovering novel structures with biological activities for various application prospects in a rapid manner. This project will also shed new light on the biosynthetic pathways of triterpenoids by uncovering new genes and enzymes and will open up opportunities for production of important triterpenoids via further metabolic manipulations in plant or microbial ‘green factories’.

 Publications

year authors and title journal last update
List of publications.
2018 Ancheng C. Huang, Young J. Hong, Andrew D. Bond, Dean J. Tantillo, Anne Osbourn
Diverged Plant Terpene Synthases Reroute the Carbocation Cyclization Path towards the Formation of Unprecedented 6/11/5 and 6/6/7/5 Sesterterpene Scaffolds
published pages: 1291-1295, ISSN: 1433-7851, DOI: 10.1002/anie.201711444
Angewandte Chemie International Edition 57/5 2019-06-13

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