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AstroWireSyn SIGNED

Wiring synaptic circuits with astroglial connexins: mechanisms, dynamics and impact for critical period plasticity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AstroWireSyn" data sheet

The following table provides information about the project.

Coordinator
COLLEGE DE FRANCE 

Organization address
address: PLACE MARCELIN BERTHELOT 11
city: PARIS
postcode: 75005
website: www.college-de-france.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www.college-de-france.fr/site/en-cirb/rouach.htm
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    COLLEGE DE FRANCE FR (PARIS) coordinator 2˙000˙000.00

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 Project objective

Brain information processing is commonly thought to be a neuronal performance. However recent data point to a key role of astrocytes in brain development, activity and pathology. Indeed astrocytes are now viewed as crucial elements of the brain circuitry that control synapse formation, maturation, activity and elimination. How do astrocytes exert such control is matter of intense research, as they are now known to participate in critical developmental periods as well as in psychiatric disorders involving synapse alterations. Thus unraveling how astrocytes control synaptic circuit formation and maturation is crucial, not only for our understanding of brain development, but also for identifying novel therapeutic targets. We recently found that connexin 30 (Cx30), an astroglial gap junction subunit expressed postnatally, tunes synaptic activity via an unprecedented non-channel function setting the proximity of glial processes to synaptic clefts, essential for synaptic glutamate clearance efficacy. Our work not only reveals Cx30 as a key determinant of glial synapse coverage, but also extends the classical model of neuroglial interactions in which astrocytes are generally considered as extrasynaptic elements indirectly regulating neurotransmission. Yet the molecular mechanisms involved in such control, its dynamic regulation by activity and impact in a native developmental context are unknown. We will now address these important questions, focusing on the involvement of this novel astroglial function in wiring developing synaptic circuits. Thus using a multidisciplinary approach we will investigate: 1) the molecular and cellular mechanisms underlying Cx30 regulation of synaptic function 2) the activity-dependent dynamics of Cx30 function at synapses 3) a role for Cx30 in wiring synaptic circuits during critical developmental periods This ambitious project will provide essential knowledge on the molecular mechanisms underlying astroglial control of synaptic circuits.

 Publications

year authors and title journal last update
List of publications.
2019 Kanishka Basnayake, David Mazaud, Alexis Bemelmans, Nathalie Rouach, Eduard Korkotian, David Holcman
Fast calcium transients in dendritic spines driven by extreme statistics
published pages: e2006202, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2006202
PLOS Biology 17/6 2020-02-13
2019 Ulrike Pannasch, Elena Dossi, Pascal Ezan, Nathalie Rouach
Astroglial Cx30 sustains neuronal population bursts independently of gap‐junction mediated biochemical coupling
published pages: 1104-1112, ISSN: 0894-1491, DOI: 10.1002/glia.23591
Glia 67/6 2020-02-13
2019 Grégory Ghézali, Flora Vasile, Nathan Curry, Marcus Fantham, Giselle Cheung, Pascal Ezan, Martine Cohen-Salmon, Clemens Kaminski, Nathalie Rouach
Neuronal Activity Drives Astroglial Connexin 30 in Perisynaptic Processes and Shapes Its Functions
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhz123
Cerebral Cortex 2020-02-13
2019 Noémie Cresto, Laure-Elise Pillet, Pierre Billuart, Nathalie Rouach
Do Astrocytes Play a Role in Intellectual Disabilities?
published pages: 518-527, ISSN: 0166-2236, DOI: 10.1016/j.tins.2019.05.011
Trends in Neurosciences 42/8 2020-02-13
2018 Grégory Ghézali, Charles-Félix Calvo, Laure-Elise Pillet, Flora Llense, Pascal Ezan, Ulrike Pannasch, Alexis-Pierre Bemelmans, Sandrine Etienne Manneville, Nathalie Rouach
Connexin 30 controls astroglial polarization during postnatal brain development
published pages: dev155275, ISSN: 0950-1991, DOI: 10.1242/dev.155275
Development 145/4 2019-06-18
2018 Elena Dossi, Flora Vasile, Nathalie Rouach
Human astrocytes in the diseased brain
published pages: 139-156, ISSN: 0361-9230, DOI: 10.1016/j.brainresbull.2017.02.001
Brain Research Bulletin 136 2019-06-18
2018 N. Rouach, K. Dao Duc, J. Sibille, D. Holcman
Dynamics of Ion Fluxes between Neurons, Astrocytes and theExtracellular Space during Neurotransmission
published pages: 1-18, ISSN: 2500-2287, DOI: 10.20388/omp2018.001.0053
Opera Medica et Physiologica Vol. 4 (1) 2019-06-18
2017 Flora Vasile, Elena Dossi, Nathalie Rouach
Human astrocytes: structure and functions in the healthy brain
published pages: 2017-2029, ISSN: 1863-2653, DOI: 10.1007/s00429-017-1383-5
Brain Structure and Function 222/5 2019-06-18
2017 Glenn Dallérac, Julien Moulard, Jean-François Benoist, Stefan Rouach, Stéphane Auvin, Angèle Guilbot, Loïc Lenoir, Nathalie Rouach
Non-ketogenic combination of nutritional strategies provides robust protection against seizures
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05542-3
Scientific Reports 7/1 2019-08-06
2019 Thomas Blauwblomme, Elena Dossi, Christophe Pellegrino, Emmanuelle Goubert, Beatriz Gal Iglesias, Christian Sainte-Rose, Nathalie Rouach, Rima Nabbout, Gilles Huberfeld
Gamma-aminobutyric acidergic transmission underlies interictal epileptogenicity in pediatric focal cortical dysplasia
published pages: 204-217, ISSN: 0364-5134, DOI: 10.1002/ana.25403
Annals of Neurology 85/2 2019-08-06
2018 Glenn Dallérac, Jonathan Zapata, Nathalie Rouach
Versatile control of synaptic circuits by astrocytes: where, when and how?
published pages: 729-743, ISSN: 1471-003X, DOI: 10.1038/s41583-018-0080-6
Nature Reviews Neuroscience 19/12 2019-08-06
2018 Elena Dossi, Thomas Blauwblomme, Julien Moulard, Oana Chever, Flora Vasile, Eleonore Guinard, Marc Le Bert, Isabelle Couillin, Johan Pallud, Laurent Capelle, Gilles Huberfeld, Nathalie Rouach
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy
published pages: eaar3796, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aar3796
Science Translational Medicine 10/443 2019-08-06
2018 Noémie Mazaré, Alice Gilbert, Anne-Cécile Boulay, Nathalie Rouach, Martine Cohen-Salmon
Connexin 30 is expressed in a subtype of mouse brain pericytes
published pages: 1017-1024, ISSN: 1863-2653, DOI: 10.1007/s00429-017-1562-4
Brain Structure and Function 223/2 2019-08-06
2017 Nathan Curry, Grégory Ghézali, Gabriele S. Kaminski Schierle, Nathalie Rouach, Clemens F. Kaminski
Correlative STED and Atomic Force Microscopy on Live Astrocytes Reveals Plasticity of Cytoskeletal Structure and Membrane Physical Properties during Polarized Migration
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00104
Frontiers in Cellular Neuroscience 11 2019-08-06

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