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ENTRAPMENT SIGNED

Septins: from bacterial entrapment to cellular immunity

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "ENTRAPMENT" data sheet

The following table provides information about the project.

Coordinator
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER 

Organization address
address: KEPPEL STREET
city: LONDON
postcode: WC1E 7HT
website: http://www.lshtm.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙744˙407 €
 EC max contribution 2˙744˙407 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER UK (LONDON) coordinator 2˙744˙407.00

Map

 Project objective

The intracellular bacterium Shigella flexneri is an exceptional model pathogen to address key issues in biology, including how bacteria can move inside host cells and escape the immune system. The cytoskeleton has recently emerged to occupy a central role in innate immunity by promoting bacterial sensing and executing antibacterial functions. I discovered that host cells employ septins, a poorly understood component of the cytoskeleton, to restrict the actin-based motility of Shigella and target them for destruction by autophagy, an important mechanism of innate immune defence. However, the processes underlying septin cage assembly, and the breadth of roles for septins in bacterial infection control, remain to be established. I developed zebrafish (Danio rerio) infection models to study the cell biology of Shigella infection in vivo, and to discover new roles for septins in host defence against bacterial infection. This approach has enabled a cutting edge platform for in vivo studies both at the single cell and whole animal level, and provides unprecedented opportunities to follow cytoskeleton dynamics and innate immunity at a resolution that cannot be achieved using any other animal model. I will now exploit the novelty of septin biology, and its direct link to host defence, as the foundation for this research programme. Using Shigella I will: (1) Discover new roles for the cytoskeleton in host defence against bacterial infection, and (2) Investigate the role of septin-mediated host defence mechanisms in vivo using zebrafish models of infection. The results generated from this research programme will provide fundamental advances in understanding septin biology and cellular immunity. They could also suggest the development of new strategies aimed at combating infectious diseases, and possibly other human diseases in which septins have been implicated including neoplasia and neurodegenerative conditions.

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