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NASCENT SIGNED

Novel Approach to Systematically Characterize Exercise- and Nutrient- responsive genes in Type 2 diabetes and cardiovascular disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NASCENT" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙875˙000 €
 EC max contribution 1˙875˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙875˙000.00

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 Project objective

Proposal summary Type 2 diabetes and cardiovascular disease are devastating and costly morbidities whose prevalences are increasing rapidly around the world. As such, there is an urgent need to develop innovative and effective prevention and treatment strategies. As numerous clinical trials have shown, lifestyle modification is by far the best way to prevent these diseases, with lifestyle being twice as effective as the best drugs, less costly and free from side effects. Yet, human biology is complex, causing some people to respond well and others poorly to the same lifestyle interventions. Thus, a huge, as yet unrealised opportunity exists to optimize the prevention and treatment of cardiometabolic diseases by tailoring lifestyle interventions to the patient’s unique biology. NASCENT is an integrated programme of research through which I will functionally annotate and later translate discoveries of gene-lifestyle interactions made through the interrogation of large epidemiological (N>100,000) datasets at my disposal. The functional annotation of these discoveries will be done using state-of-the-art epigenomic and targeted gene editing tools, whereas the translation of those findings will be achieved using a innovative and powerful clinical trial design that focuses on treatments that are tailored to the participant’s genotype (genotype-based recall). NASCENT capitalizes on a solid foundation of cohorts, methods, and expertise that I have built-up over the past fifteen years, but also exploits state-of-the-art epigenomic and gene-editing technologies that have not previously been used in studies of gene-lifestyle interactions. I expect the integration of these established and new approaches in NASCENT to propel major advances in understanding gene-lifestyle interactions in cardiometabolic disease that help optimise disease prevention.

 Publications

year authors and title journal last update
List of publications.
2018 Paul W. Franks, Nicholas J. Timpson
Genotype-Based Recall Studies in Complex Cardiometabolic Traits
published pages: , ISSN: 2574-8300, DOI: 10.1161/CIRCGEN.118.001947
Circulation: Genomic and Precision Medicine 11/8 2019-04-18
2016 P. W. Franks, M. I. McCarthy
Exposing the exposures responsible for type 2 diabetes and obesity
published pages: 69-73, ISSN: 0036-8075, DOI: 10.1126/science.aaf5094
Science 354/6308 2019-04-03
2017 P. W. Franks, N. Atabaki-Pasdar
Causal inference in obesity research
published pages: 222-232, ISSN: 0954-6820, DOI: 10.1111/joim.12577
Journal of Internal Medicine 281/3 2019-04-03
2017 Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian\'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P. Morris, Nita G. Forouhi, Cecilia Lindgren, Patrik K. E. Magnusson, Nancy L. Pedersen, Göran Hallmans, Audrey Y. Chu, Anne E. Justice, Mariaelisa Graff, Thomas W. Winkler, Lynda M. Rose, Claudia Langenberg, L. Adrienne Cupples, Paul M. Ridker, Nicholas J. Wareham, Ken K. Ong, Ruth J. F. Loos, Daniel I. Chasman, Erik Ingelsson, Tuomas O. Kilpeläinen, Robert A. Scott, Reedik Mägi, Guillaume Paré, Paul W. Franks
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions
published pages: e1006812, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006812
PLOS Genetics 13/6 2019-04-03
2017 Paul W Franks, Alaitz Poveda
Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?
published pages: 784-792, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4207-5
Diabetologia 60/5 2019-04-04
2016 Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Dmitry Shungin, Azra Kurbasic, Erik Ingelsson, Ewan R. Pearson, Ashfaq Ali, Paul W. Franks
Statistical power considerations in genotype-based recall randomized controlled trials
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep37307
Scientific Reports 6/1 2019-04-04
2018 Yan Chen, Angela C. Estampador, Maria Keller, Alaitz Poveda, Jonathan Dalla-Riva, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W. Franks, Tibor V. Varga
The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study
published pages: , ISSN: 0307-0565, DOI: 10.1038/s41366-018-0112-3
International Journal of Obesity 2019-04-03
2016 Anders Grøntved, Robert W. Koivula, Ingegerd Johansson, Patrik Wennberg, Lars Østergaard, Göran Hallmans, Frida Renström, Paul W. Franks
Bicycling to Work and Primordial Prevention of Cardiovascular Risk: A Cohort Study Among Swedish Men and Women
published pages: , ISSN: 2047-9980, DOI: 10.1161/JAHA.116.004413
Journal of the American Heart Association 5/11 2019-04-04
2016 S Ahmad, A Poveda, D Shungin, I Barroso, G Hallmans, F Renström, P W Franks
Established BMI-associated genetic variants and their prospective associations with BMI and other cardiometabolic traits: the GLACIER Study
published pages: 1346-1352, ISSN: 0307-0565, DOI: 10.1038/ijo.2016.72
International Journal of Obesity 40/9 2019-04-04
2018 Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Stephen O’Rahilly, Michael J. Owen, Colin N. A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D. Tobin, Louise V. Wain, George Davey Smith, David M. Evans, Fredrik Karpe, Mark I. McCarthy, John Danesh, Paul W. Franks, Nicholas J. Timpson
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03109-y
Nature Communications 9/1 2019-04-04
2017 Tibor V. Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian’an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M. Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A. Scott, Nicholas J. Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W. Franks
Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults
published pages: dyw245, ISSN: 0300-5771, DOI: 10.1093/ije/dyw245
International Journal of Epidemiology 2019-04-03
2017 Alaitz Poveda, Yan Chen, Anders Brändström, Elisabeth Engberg, Göran Hallmans, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W. Franks
The heritable basis of gene–environment interactions in cardiometabolic traits
published pages: 442-452, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4184-0
Diabetologia 60/3 2019-04-03
2018 Hugo Fitipaldi, Mark I. McCarthy, Jose C. Florez, Paul W. Franks
A Global Overview of Precision Medicine in Type 2 Diabetes
published pages: 1911-1922, ISSN: 0012-1797, DOI: 10.2337/dbi17-0045
Diabetes 67/10 2019-04-04
2017 Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Lifestyle precision medicine: the next generation in type 2 diabetes prevention?
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0938-x
BMC Medicine 15/1 2019-04-04

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