Explore the words cloud of the DAMOC project. It provides you a very rough idea of what is the project "DAMOC" about.
The following table provides information about the project.
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
|Coordinator Country||Spain [ES]|
|Total cost||1˙499˙554 €|
|EC max contribution||1˙499˙554 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA||ES (BARCELONA)||coordinator||1˙499˙554.00|
Insulin secretion and insulin action are critical for normal glucose homeostasis. Defects in both of these processes lead to type 2 diabetes (T2D). Unravelling the mechanisms that lead to T2D is fundamental in the search of new molecular drugs to prevent and control this disease. Organ-on-a-chip devices offer new approaches for T2D disease modelling and drug discovery by providing biologically relevant models of tissues and organs in vitro integrated with biosensors. As such, organ-on-a-chip devices have the potential to revolutionize the pharmaceutical industry by enabling reliable and high predictive in vitro testing of drug candidates. The capability to miniaturize biosensor systems and advanced tissue fabrication procedures have enabled researchers to create multiple tissues on a chip with a high degree of control over experimental variables for high-content screening applications. The goal of this project is the fabrication of a biomimetic multi organ-on-a-chip integrated device composed of skeletal muscle and pancreatic islets for studying metabolism glucose diseases and for drug screening applications. Engineered muscle tissues and pancreatic islets are integrated with the technology to detect the glucose consumption, contraction induced glucose metabolism, insulin secretion and protein biomarker secretion of cells. We aim to design a novel therapeutic tool to test drugs with a multi organ-on-a-chip device. Such finding would improve drug test approaches and would provide for new therapies to prevent the loss of beta cell mass associated with T2D and defects in the glucose uptake in skeletal muscle.
|year||authors and title||journal||last update|
Francesco De Chiara, Cynthia Ureta Checcllo, Javier RamÃ³n AzcÃ³n
High Protein Diet and Metabolic Plasticity in Non-Alcoholic Fatty Liver Disease: Myths and Truths
published pages: 2985, ISSN: 2072-6643, DOI: 10.3390/nu11122985
Alejandro HernÃ¡ndez-Albors, Albert G. CastaÃ±o, Xiomara FernÃ¡ndez-Garibay, MarÃa Alejandra Ortega, Jordina Balaguer, Javier RamÃ³n-AzcÃ³n
Microphysiological sensing platform for an in-situ detection of tissue-secreted cytokines
published pages: 100025, ISSN: 2590-1370, DOI: 10.1016/j.biosx.2019.100025
|Biosensors and Bioelectronics: X 2||2019-10-01|
Kosuke Ino, Yuji Nashimoto, Noriko Taira, Javier Ramon Azcon, Hitoshi Shiku
Intracellular Electrochemical Sensing
published pages: 2195-2209, ISSN: 1040-0397, DOI: 10.1002/elan.201800410
MarÃa A. Ortega, Xiomara FernÃ¡ndez-Garibay, Albert G. CastaÃ±o, Francesco De Chiara, Alejandro HernÃ¡ndez-Albors, Jordina Balaguer-Trias, Javier RamÃ³n-AzcÃ³n
Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted IL-6 and TNF-Î±
published pages: , ISSN: 1473-0197, DOI: 10.1039/c9lc00285e
|Lab on a Chip||2019-09-02|
Andrea GarcÃa-Lizarribar, Xiomara FernÃ¡ndez-Garibay, Ferran Velasco-MallorquÃ, Albert G. CastaÃ±o, Josep Samitier, Javier Ramon-Azcon
Composite Biomaterials as Long-Lasting Scaffolds for 3D Bioprinting of Highly Aligned Muscle Tissue
published pages: 1800167, ISSN: 1616-5187, DOI: 10.1002/mabi.201800167
|Macromolecular Bioscience 18/10||2019-09-02|
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