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DAMOC SIGNED

Diabetes Approach by Multi-Organ-on-a-Chip

Total Cost €

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EC-Contrib. €

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Partnership

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Project "DAMOC" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙499˙554 €
 EC max contribution 1˙499˙554 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 1˙499˙554.00

Map

 Project objective

Insulin secretion and insulin action are critical for normal glucose homeostasis. Defects in both of these processes lead to type 2 diabetes (T2D). Unravelling the mechanisms that lead to T2D is fundamental in the search of new molecular drugs to prevent and control this disease. Organ-on-a-chip devices offer new approaches for T2D disease modelling and drug discovery by providing biologically relevant models of tissues and organs in vitro integrated with biosensors. As such, organ-on-a-chip devices have the potential to revolutionize the pharmaceutical industry by enabling reliable and high predictive in vitro testing of drug candidates. The capability to miniaturize biosensor systems and advanced tissue fabrication procedures have enabled researchers to create multiple tissues on a chip with a high degree of control over experimental variables for high-content screening applications. The goal of this project is the fabrication of a biomimetic multi organ-on-a-chip integrated device composed of skeletal muscle and pancreatic islets for studying metabolism glucose diseases and for drug screening applications. Engineered muscle tissues and pancreatic islets are integrated with the technology to detect the glucose consumption, contraction induced glucose metabolism, insulin secretion and protein biomarker secretion of cells. We aim to design a novel therapeutic tool to test drugs with a multi organ-on-a-chip device. Such finding would improve drug test approaches and would provide for new therapies to prevent the loss of beta cell mass associated with T2D and defects in the glucose uptake in skeletal muscle.

 Publications

year authors and title journal last update
List of publications.
2019 Francesco De Chiara, Cynthia Ureta Checcllo, Javier Ramón Azcón
High Protein Diet and Metabolic Plasticity in Non-Alcoholic Fatty Liver Disease: Myths and Truths
published pages: 2985, ISSN: 2072-6643, DOI: 10.3390/nu11122985
Nutrients 11/12 2020-03-05
2019 Alejandro Hernández-Albors, Albert G. Castaño, Xiomara Fernández-Garibay, María Alejandra Ortega, Jordina Balaguer, Javier Ramón-Azcón
Microphysiological sensing platform for an in-situ detection of tissue-secreted cytokines
published pages: 100025, ISSN: 2590-1370, DOI: 10.1016/j.biosx.2019.100025
Biosensors and Bioelectronics: X 2 2019-10-01
2018 Kosuke Ino, Yuji Nashimoto, Noriko Taira, Javier Ramon Azcon, Hitoshi Shiku
Intracellular Electrochemical Sensing
published pages: 2195-2209, ISSN: 1040-0397, DOI: 10.1002/elan.201800410
Electroanalysis 30/10 2019-09-02
2019 María A. Ortega, Xiomara Fernández-Garibay, Albert G. Castaño, Francesco De Chiara, Alejandro Hernández-Albors, Jordina Balaguer-Trias, Javier Ramón-Azcón
Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted IL-6 and TNF-α
published pages: , ISSN: 1473-0197, DOI: 10.1039/c9lc00285e
Lab on a Chip 2019-09-02
2018 Andrea García-Lizarribar, Xiomara Fernández-Garibay, Ferran Velasco-Mallorquí, Albert G. Castaño, Josep Samitier, Javier Ramon-Azcon
Composite Biomaterials as Long-Lasting Scaffolds for 3D Bioprinting of Highly Aligned Muscle Tissue
published pages: 1800167, ISSN: 1616-5187, DOI: 10.1002/mabi.201800167
Macromolecular Bioscience 18/10 2019-09-02

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