Opendata, web and dolomites


Novel treatment for peripheral arterial disease

Total Cost €


EC-Contrib. €






 FlowOx project word cloud

Explore the words cloud of the FlowOx project. It provides you a very rough idea of what is the project "FlowOx" about.

clinical    limb    clinically    trajectory    finland    enter    secure    costly    causing    medical    model    critical    20    amounts    fatty    walls    home    innovation    patients    join    introduction    uk    social    treatment    caused    innokas    extensive    commercial    million    scandinavia    health    manufacturing    nutrition    gaining    chronic    202    walk    pad    billion    manufacturer    pilot    period    arteries    technically    validated    efficacy    population    demanding    vascular    forces    successful    market    cessation    rate    recommended    epidemic    launch    deposition    arterial    amputation    reducing    behavioural    progress    local    flowox    bangor    smoking    positon    solution    diabetes    inner    muscles    univ    risk    surgery    210    annum    fill    gap    reduce    stage    2020    peripheral    salford    roadmap    care    pain    220    germany    healthy    exercise    patented    380    ischemia    resource    unbearable    material    economic    fast    globally    follow    people    aging    sales    track    worsens    device    disease    world    skin    wounds    otivio    perfusion    gaps   

Project "FlowOx" data sheet

The following table provides information about the project.


Organization address
city: OSLO
postcode: 349
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website
 Total cost 2˙747˙678 €
 EC max contribution 2˙080˙500 € (76%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2. (PRIORITY 'Industrial leadership')
 Code Call H2020-FTIPilot-2016-1
 Funding Scheme IA
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2019-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OTIVIO AS NO (OSLO) coordinator 876˙000.00
2    INNOKAS MEDICAL OY FI (KEMPELE) participant 680˙750.00
3    THE UNIVERSITY OF SALFORD UK (SALFORD) participant 375˙000.00
4    BANGOR UNIVERSITY UK (BANGOR) participant 148˙750.00


 Project objective

Peripheral Arterial Disease (PAD) is caused by the deposition of fatty material on the inner walls of peripheral arteries causing reducing perfusion and local nutrition to the muscles and skin. The condition affect 202 million people globally and is increasing at a rate of 20% per annum due to an aging population and epidemic growth of diabetes. The social costs amounts to $210 - 380 billion per annum. Behavioural changes such as smoking cessation, healthy nutrition and exercise is recommended to reduce impact and risk. When the condition worsens, patients ability to walk and exercise is reduced. When disease progress to critical limb ischemia (unbearable pain and chronic wounds), the patients follow a trajectory towards costly vascular surgery or amputation. FlowOx targets the gap in care with a patented, cost effective and clinically promising home treatment solution. In order to secure the successful introduction of FlowOx into the market by 2020, resources are required to fill the following gaps in innovation:1) strong clinical evidence of efficacy 2) health economic assessment 3) design for large scale manufacturing and 4) a validated commercial model Germany, UK and Scandinavia. These 4 challenges will be addressed in the FlowOx project over a 30-month period. The Fast Track to Innovation Pilot program was selected to support a resource demanding and technically challenging stage of the product roadmap. The support enables Otivio to join forces with a medical device manufacturer, Innokas Medical, Finland, and UK based Univ. of Salford and Univ. of Bangor with extensive experience in clinical and health economic studies. The FlowOx project enables Otivio and Innokas to enter the world-wide PAD market, gaining a strong market positon with a home care device for PAD treatment and expected sales of over €220 million within 5 years of launch.


List of deliverables.
Project Website Websites, patent fillings, videos etc. 2020-03-23 19:00:21
CE mark Documents, reports 2020-03-23 19:00:18

Take a look to the deliverables list in detail:  detailed list of FlowOx deliverables.


year authors and title journal last update
List of publications.
2018 Øyvind Heiberg Sundby, Ingebjørg Irgens, Lars Øivind Høiseth, Iacob Mathiesen, Eivind Lundgaard, Hanne Haugland, Harald Weedon-Fekjær, Jon O. Sundhagen, Gunnar Sandbæk, Jonny Hisdal
Intermittent mild negative pressure applied to the lower limb in patients with spinal cord injury and chronic lower limb ulcers: a crossover pilot study
published pages: 372-381, ISSN: 1362-4393, DOI: 10.1038/s41393-018-0080-4
Spinal Cord 56/4 2019-07-18
2017 Øyvind Heiberg Sundby, Lars Øivind Høiseth, Iacob Mathiesen, Harald Weedon-Fekjær, Jon O. Sundhagen, Jonny Hisdal
The acute effects of lower limb intermittent negative pressure on foot macro- and microcirculation in patients with peripheral arterial disease
published pages: e0179001, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0179001
PLOS ONE 12/6 2019-07-18
2016 Øyvind H. Sundby, Lars Ø. Høiseth, Iacob Mathiesen, Jørgen J. Jørgensen, Jon O. Sundhagen, Jonny Hisdal
The effects of intermittent negative pressure on the lower extremities\' peripheral circulation and wound healing in four patients with lower limb ischemia and hard-to-heal leg ulcers: a case report
published pages: e12998, ISSN: 2051-817X, DOI: 10.14814/phy2.12998
Physiological Reports 4/20 2019-07-18

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The information about "FLOWOX" are provided by the European Opendata Portal: CORDIS opendata.

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