Opendata, web and dolomites


Novel treatment for peripheral arterial disease

Total Cost €


EC-Contrib. €






 FlowOx project word cloud

Explore the words cloud of the FlowOx project. It provides you a very rough idea of what is the project "FlowOx" about.

recommended    2020    epidemic    gaining    critical    positon    costly    manufacturer    solution    aging    world    extensive    perfusion    enter    disease    deposition    device    surgery    univ    limb    globally    health    nutrition    trajectory    innovation    uk    20    roadmap    germany    medical    million    reducing    scandinavia    rate    chronic    manufacturing    material    clinically    successful    healthy    patients    otivio    causing    pad    caused    unbearable    walls    technically    progress    sales    home    behavioural    model    210    track    efficacy    inner    resource    demanding    walk    fatty    period    launch    population    fill    economic    380    salford    220    innokas    diabetes    bangor    peripheral    smoking    follow    wounds    risk    muscles    stage    social    local    exercise    annum    people    arteries    finland    cessation    vascular    gaps    introduction    pilot    amputation    flowox    patented    care    worsens    treatment    commercial    amounts    validated    reduce    forces    pain    202    ischemia    arterial    join    gap    secure    fast    market    skin    clinical    billion   

Project "FlowOx" data sheet

The following table provides information about the project.


Organization address
city: OSLO
postcode: 349
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website
 Total cost 2˙747˙678 €
 EC max contribution 2˙080˙500 € (76%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2. (PRIORITY 'Industrial leadership')
 Code Call H2020-FTIPilot-2016-1
 Funding Scheme IA
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2019-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OTIVIO AS NO (OSLO) coordinator 876˙000.00
2    INNOKAS MEDICAL OY FI (KEMPELE) participant 680˙750.00
3    THE UNIVERSITY OF SALFORD UK (SALFORD) participant 375˙000.00
4    BANGOR UNIVERSITY UK (BANGOR) participant 148˙750.00


 Project objective

Peripheral Arterial Disease (PAD) is caused by the deposition of fatty material on the inner walls of peripheral arteries causing reducing perfusion and local nutrition to the muscles and skin. The condition affect 202 million people globally and is increasing at a rate of 20% per annum due to an aging population and epidemic growth of diabetes. The social costs amounts to $210 - 380 billion per annum. Behavioural changes such as smoking cessation, healthy nutrition and exercise is recommended to reduce impact and risk. When the condition worsens, patients ability to walk and exercise is reduced. When disease progress to critical limb ischemia (unbearable pain and chronic wounds), the patients follow a trajectory towards costly vascular surgery or amputation. FlowOx targets the gap in care with a patented, cost effective and clinically promising home treatment solution. In order to secure the successful introduction of FlowOx into the market by 2020, resources are required to fill the following gaps in innovation:1) strong clinical evidence of efficacy 2) health economic assessment 3) design for large scale manufacturing and 4) a validated commercial model Germany, UK and Scandinavia. These 4 challenges will be addressed in the FlowOx project over a 30-month period. The Fast Track to Innovation Pilot program was selected to support a resource demanding and technically challenging stage of the product roadmap. The support enables Otivio to join forces with a medical device manufacturer, Innokas Medical, Finland, and UK based Univ. of Salford and Univ. of Bangor with extensive experience in clinical and health economic studies. The FlowOx project enables Otivio and Innokas to enter the world-wide PAD market, gaining a strong market positon with a home care device for PAD treatment and expected sales of over €220 million within 5 years of launch.


List of deliverables.
Project Website Websites, patent fillings, videos etc. 2020-03-23 19:00:21
CE mark Documents, reports 2020-03-23 19:00:18

Take a look to the deliverables list in detail:  detailed list of FlowOx deliverables.


year authors and title journal last update
List of publications.
2018 Øyvind Heiberg Sundby, Ingebjørg Irgens, Lars Øivind Høiseth, Iacob Mathiesen, Eivind Lundgaard, Hanne Haugland, Harald Weedon-Fekjær, Jon O. Sundhagen, Gunnar Sandbæk, Jonny Hisdal
Intermittent mild negative pressure applied to the lower limb in patients with spinal cord injury and chronic lower limb ulcers: a crossover pilot study
published pages: 372-381, ISSN: 1362-4393, DOI: 10.1038/s41393-018-0080-4
Spinal Cord 56/4 2019-07-18
2017 Øyvind Heiberg Sundby, Lars Øivind Høiseth, Iacob Mathiesen, Harald Weedon-Fekjær, Jon O. Sundhagen, Jonny Hisdal
The acute effects of lower limb intermittent negative pressure on foot macro- and microcirculation in patients with peripheral arterial disease
published pages: e0179001, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0179001
PLOS ONE 12/6 2019-07-18
2016 Øyvind H. Sundby, Lars Ø. Høiseth, Iacob Mathiesen, Jørgen J. Jørgensen, Jon O. Sundhagen, Jonny Hisdal
The effects of intermittent negative pressure on the lower extremities\' peripheral circulation and wound healing in four patients with lower limb ischemia and hard-to-heal leg ulcers: a case report
published pages: e12998, ISSN: 2051-817X, DOI: 10.14814/phy2.12998
Physiological Reports 4/20 2019-07-18

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The information about "FLOWOX" are provided by the European Opendata Portal: CORDIS opendata.

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