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NMR4Nanos

Development and application of NMR-based tools to inorganic nanocarriers for effective vaccine delivery

Total Cost €

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EC-Contrib. €

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Partnership

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 NMR4Nanos project word cloud

Explore the words cloud of the NMR4Nanos project. It provides you a very rough idea of what is the project "NMR4Nanos" about.

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Project "NMR4Nanos" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT GENT 

Organization address
address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000
website: http://www.ugent.be

contact info
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name: n.a.
surname: n.a.
function: n.a.
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 Coordinator Country Belgium [BE]
 Project website https://www.ugent.be/en/research/research-ugent/trackrecord/trackrecord-h2020/msca-h2020/msca-nmr4nanos.htm
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-04   to  2019-09-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT BE (GENT) coordinator 172˙800.00

Map

 Project objective

There is an urgent need for new vaccines, but avoiding side effects is crucial for patient compliance. To address this, new generation vaccines with safe, but weakly immunogenic antigens are formulated with carriers and adjuvants to induce the desired immunological response. Inorganic nanoparticles (NP) have shown potential as carriers while immune stimulators of microbial origin are proven to ensure long lasting immune response. Their successful integration into nanovaccines requires thorough analysis of the inorganic/organic interface. Solution state NMR spectroscopy has recently been established as a potent characterisation tool towards this end. My objective is twofold: I intend to elaborate new vaccine-carrier nanosystems and to develop NMR spectroscopic surface characterization methods for their analysis that may be generalized for application to other NPs. I will use my expertise in preparative colloid chemistry to tailor series of new ZrO2- and hydroxyapatite-based NPs of varied size. For their characterisation I will be trained to carry out solution NMR measurements from the toolbox developed by the Host. The outcome will be invaluable for guiding the surface modification of these NPs to obtain vaccine carriers. The project also aims at the further development of NMR methodology. The potential of solid state NMR measurements in this respect will be explored as a secondment. Another secondment is devoted to the early study of in vitro stability, fate and toxicity of the new carriers. The planned research will train me in a cutting-edge analysis technique, and by that means provide me more independence in my work. Furthermore, it will establish an interdisciplinary cooperation between Partner Institutes. The results and the planned outreach activities are also expected to have a positive impact on EU: these new characterization tools would be useful for food, cosmetic and nanomedicine industries and may contribute to improved customer and patient safety.

 Publications

year authors and title journal last update
List of publications.
2018 Livia Naszalyi Nagy, Aranit Harizaj, Evert Dhaene, Krisztina Fehér, Kevin Braeckmans, José Martins
Silica@zirconia core@shell ceramics as vaccine nanocarriers
published pages: 127, ISSN: , DOI:
(2018) Biological Barriers, 12th International conference and workshop 2020-02-27
2018 Livia Naszalyi Nagy, Rein Verbeke, Heleen Dewitte, Krisztina Fehér, Stefaan De Smedt, José C. Martins
Ceramic core@shell nanospheres as vaccine carriers
published pages: 65, ISSN: , DOI:
11th Conference on Colloid Chemistry (11-CCC) 2020-02-27
2019 Livia Naszályi Nagy, Evert Dhaene, Krisztina Fehér, Isabel Van Driessche, José C. Martins
DNA building block adsorption on SiO2@ZrO2 NPs
published pages: 54, ISSN: , DOI:
Chemistry Physics and Biology of Colloids and Interfaces (CPBCI 18) 2020-02-27

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