Opendata, web and dolomites

PIMS SIGNED

Mechanistic studies of long chain omega-3 fatty acid supplementation and inflammation in metabolic syndrome.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "PIMS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LYON 1 CLAUDE BERNARD 

Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
city: VILLEURBANNE CEDEX
postcode: 69622
website: www.univ-Iyon1.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 232˙160 €
 EC max contribution 232˙160 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) coordinator 232˙160.00
2    UNIVERSITE LAVAL CA (QUEBEC) partner 0.00

Map

 Project objective

Subclinical inflammation is a key factor in the development of cardiovascular diseases. Obesity and metabolic syndrome (MetS), both diet and lifestyle-related, are highly prevalent causes of subclinical inflammation. A growing body of literature suggests that dietary long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) may attenuate MetS-associated pro-inflammatory state. However, it remains unclear whether the different LCn-3PUFA, primarily docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have similar effects on pro-inflammatory processes because most previous studies used them in mixture. Whether efficacy of LCn-3PUFA is influenced by sex/gender is also unknown. The objective of the proposed research is thus to compare the anti-inflammatory effects of EPA and DHA in humans with MetS through very innovative kinetics and molecular studies. We will compare in a double-blind, crossover randomized placebo-controlled study in men and women with MetS (i) the impact of EPA and DHA supplementation on the plasma in vivo kinetics of inflammatory biomarkers using stable isotopes and (ii) the anti-inflammatory molecular mechanisms of EPA and DHA at both adipose tissue and systemic levels. The role of lipid mediators specific to EPA and DHA in this process will be addressed by quantifying (i) oxygenated derivatives from EPA and DHA in plasma, (ii) their molecular targets in adipose tissue and (iii) markers of oxidative stress in plasma. The proposed research shall be one of the most comprehensive studies comparing the impact of EPA and DHA on both systemic and adipose tissue-specific subclinical inflammation to date. The in-depth understanding of their effects and possible gender differences will be extremely novel. Such data will provide much needed evidence-based justification for the use of specific dietary treatment modalities in men and women with MetS, which can further guide policy makers and health professionals for potential prevention strategies.

 Publications

year authors and title journal last update
List of publications.
2017 Cécile Vors, Janie Allaire, Johanne Marin, Marie-Claude Lépine, Amélie Charest, André Tchernof, Patrick Couture, Benoît Lamarche
Inflammatory gene expression in whole blood cells after EPA vs. DHA supplementation: Results from the ComparED study
published pages: 116-122, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2017.01.025
Atherosclerosis 257 2019-08-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PIMS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PIMS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MathematicsAnalogies (2019)

Mathematics Analogies

Read More  

DiMaS (2019)

Retrospective genomic analyses of shortfin Mako shark (Isurus oxyrinchus) using DNA from archived jaws

Read More  

FOCUSIS (2020)

Focal volume Control Using Structured Illumination Sources

Read More