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EcoLipid SIGNED

Ecophysiology of membrane lipid remodelling in marine bacteria

Total Cost €

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EC-Contrib. €

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Partnership

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 EcoLipid project word cloud

Explore the words cloud of the EcoLipid project. It provides you a very rough idea of what is the project "EcoLipid" about.

phosphatidylglycerol    cell    numerically    functioning    lack    stresses    waters    environment    phosphorus    knock    composition    microbial    cells    cycles    biology    deficiency    abiotic    phosphatidylethanolamine    restricting    membranes    glycolipids    myself    ecological    ecophysiology    trade    sulfolipids    synthesis    physiological    advantage    demonstrated    clades    insights    thought    bacteria    membrane    marine    fitness    predominantly    hypothesize    bacterial    heterotrophic    escherichia    adapt    sar11    oligotrophic    lipids    free    occurs    until    basis    reveal    players    structural    phytoplankton    environments    biogeochemical    coli    omics    cycling    capacity    nutrient    unknown    roseobacter    uses    physiology    molecular    whereby    limitation    phospholipids    heterotrophs    sulfur    remodelling    abundant    envelope    substitute    competitive    ornithine    significantly    cosmopolitan    biotic    stress    offers    found    containing    deal    betaine    lipid    ecologically    organisms    form    profound    remodeling    offs   

Project "EcoLipid" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://warwick.ac.uk/fac/sci/lifesci/research/ychen/5
 Total cost 1˙965˙113 €
 EC max contribution 1˙965˙113 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 1˙965˙113.00

Map

 Project objective

'Membrane lipids form the structural basis of all cells. In bacteria Escherichia coli uses predominantly phosphorus-containing lipids (phospholipids) in its cell envelope, including phosphatidylethanolamine and phosphatidylglycerol. However, beyond E. coli a range of lipids are found in bacterial membranes, including phospholipids as well as phosphorus (P)-free lipids such as betaine lipids, ornithine lipids, sulfolipids and glycolipids. In the marine environment, it is well established that P availability significantly affects lipid composition in the phytoplankton, whereby non-P sulfur-containing lipids are used to substitute phospholipids in response to P stress. This remodeling offers a significant competitive advantage for these organisms, allowing them to adapt to oligotrophic environments low in P. Until very recently, abundant marine heterotrophic bacteria were thought to lack the capacity for lipid remodelling in response to P deficiency. However, recent work by myself and others has now demonstrated that lipid remodelling occurs in many ecologically important marine heterotrophs, such as the SAR11 and Roseobacter clades, which are not only numerically abundant in marine waters but also crucial players in the biogeochemical cycling of key elements. However, the ecological and physiological consequences of lipid remodeling, in response to nutrient limitation, remain unknown. This is important because I hypothesize that lipid remodeling has important knock-on effects restricting the ability of marine bacteria to deal with both abiotic and biotic stresses, which has profound consequences for the functioning of major biogeochemical cycles. Here I aim to use a synthesis of molecular biology, microbial physiology, and 'omics' approaches to reveal the fitness trade-offs of lipid remodelling in cosmopolitan marine heterotrophic bacteria, providing novel insights into the ecophysiology of lipid remodelling and its consequences for marine nutrient cycling.'

 Publications

year authors and title journal last update
List of publications.
2018 Alastair F. Smith, Branko Rihtman, Rachel Stirrup, Eleonora Silvano, Michaela A. Mausz, David J. Scanlan, Yin Chen
Elucidation of glutamine lipid biosynthesis in marine bacteria reveals its importance under phosphorus deplete growth in Rhodobacteraceae
published pages: , ISSN: 1751-7362, DOI: 10.1038/s41396-018-0249-z
The ISME Journal 2019-04-04

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