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BETASCREEN SIGNED

Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BETASCREEN" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 149˙365 €
 EC max contribution 149˙365 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2018-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 149˙365.00

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 Project objective

Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications

To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution. We therefore transplant pancreatic islets into the anterior chamber of the eye (ACE) of mice for functional microscopic imaging. In the ACE islets become vascularized and innervated, and various aspects of β-cell function and survival can be readily imaged. Functional studies demonstrate that engrafted islets in the eye serve as representative reporters of endogenous islets in the pancreas of the same animal. We have extensively in vitro tested fluorescent biosensors that reflect key-events in β-cell function and survival. Following intraocular transplantation of human islets expressing biosensors in their β-cells into healthy or diabetic mice, they will allow non-invasive, longitudinal in vivo monitoring of 1) Ca2 handling, 2) functional β-cell mass, 3) apoptosis and 4) proliferation. Based on the in vitro tested biosensors, the major objective is to establish a robust pharma-industry in vivo platform for validating newly developed diabetes treatment lead-compounds in early drug development. This screening service shall be performed on a commercial basis. The milestone of this proposal, to be achieved within 18 months, is the validation of the in vivo platform for testing the effects of new potential diabetes medicines on human β-cell function and survival in normal and diabetic mice.

 Publications

year authors and title journal last update
List of publications.
2017 Ingo B. Leibiger, Per-Olof Berggren
Intraocular in vivo imaging of pancreatic islet cell physiology/pathology
published pages: 1002-1009, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.03.014
Molecular Metabolism 6/9 2019-06-12
2018 Meike Paschen, Tilo Moede, Ismael Valladolid-Acebes, Barbara Leibiger, Noah Moruzzi, Stefan Jacob, Concha F. García-Prieto, Kerstin Brismar, Ingo B. Leibiger, Per-Olof Berggren
Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass
published pages: fj.201800826R, ISSN: 0892-6638, DOI: 10.1096/fj.201800826R
The FASEB Journal 2019-06-12

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