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FusionPAMPs SIGNED

New generation of chimeric TLR2-NOD agonist compounds for vaccine adjuvants

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 FusionPAMPs project word cloud

Explore the words cloud of the FusionPAMPs project. It provides you a very rough idea of what is the project "FusionPAMPs" about.

infection    lower    prr    nod    turn    activation    activate    tlrs    modulators    minimizing    vaccination    exposed    molecular    regard    th2    pprs    adjuvants    safe    augment    quality    immunity    activated    mucosal    drives    microbial    pattern    protective    signal    cross    direct    innate    adjuvant    almost    chimeric    concentrations    effector    new    cytokines    vaccine    synergistic    immune    compound    single    performance    receptors    recognition    lectin    transduction    prrs    linking    peptidoglycan    stimulation    aluminium    attractive    intracellular    tlr2    lipopeptides    regulate    nlrs    agonists    fusion    surfaces    efficient    patterns    covalent    cell    modalities    adaptive    cells    pamps    potent    alum    compounds    quantity    pathogens    leads    ing    thereby    human    salt    expressed    talk    defences    potently    primarily    ctls    vaccines    pathogen    microbes    employed    fragments    toll    rely    lipopolysaccharides    senses   

Project "FusionPAMPs" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.uu.nl/en/research/chemical-biology-and-drug-discovery
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 177˙598.00

Map

 Project objective

New vaccine modalities need to be developed that can activate more potently the immune system, in this regard, adjuvants augment adaptive immune responses and can improve vaccine performance. Aluminium salt (alum) is the most commonly used adjuvant for human vaccination. However, it drives primarily TH2-effector responses and is not effective for vaccines that target mucosal surfaces. Thus, safe and potent adjuvants need to be developed that can increase and direct vaccine-specific immunity. Recent advances in our understanding of innate immune responses are providing opportunities to design better adjuvants. The innate immune system senses microbes through pattern-recognition receptors (PPRs), which include the Toll-like receptors (TLRs), and intracellular NOD-like receptors (NLRs) and C-type lectin-like (CTLs) receptors that are expressed by immune cells. Activation of these receptors leads to the production of cytokines that provide early defences during infection. Cytokines also regulate adaptive immunity by controlling the quantity and quality of B and T cell activation, which in turn results in protective immune responses to pathogens. Pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides, lipopeptides, and peptidoglycan fragments can activate PPRs and are attractive compounds for the development of new adjuvant. Although during microbial infection many different PRRs are activated, almost all adjuvants that are being developed rely on the stimulation of a single PRR. In this project, we propose that compound adjuvants derived by the covalent linking of two PAMPs (fusion PAMPs), for example, TLR2 and NOD agonists, will ensure that immune cells are being exposed to both, resulting in efficient cross talk of signal transduction pathways and in synergistic immune activation. If so, chimeric immune modulators (fusion PAMPs) can be employed at lower adjuvant concentrations, thereby minimizing unwanted side effects.

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The information about "FUSIONPAMPS" are provided by the European Opendata Portal: CORDIS opendata.

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